Pharmacy worker practices related to use of misoprostol for abortion in one Mexican state.

Abstract:

BACKGROUND:Pharmacies are important sites for access to health information and medications in Mexico. Most workers are not trained in health issues and may provide inaccurate information to consumers. Misoprostol is used by women throughout Mexico for early abortion and often is purchased from pharmacies. This study aims to understand the practices of pharmacy workers when asked for advice about and medications for abortion, in particular misoprostol. STUDY DESIGN:A random sample of pharmacies in both urban and rural areas of one state of Mexico included both chain and independent pharmacies (n=169). Two mystery clients (MCs) visited the pharmacies, requesting medication for "bringing down the period" and then asking for misoprostol. MCs recorded information about the interactions following each visit in standardized formats. Bivariate comparisons were made between spontaneous and prompted discussions of misoprostol. Associations were considered statistically significant at alpha<.05. RESULTS:Ninety percent of pharmacy workers attending to the MCs discussed misoprostol as an abortifacient, either spontaneously or after being prompted by the MCs. Misoprostol was for sale in most (61%) of these pharmacies. The majority of pharmacy workers (75%) did not request a prescription. Over 75% of all pharmacy workers provided the MCs referral to trained medical providers with whom they could seek a follow-up visit. Sixteen percent of pharmacy workers suggested a regimen consistent with evidence and recommendations for using misoprostol for early abortion. Regimens that were underdosages were common, and few workers recommended a potentially harmful overdosage. Instructions about side effects and risks were rare. The price of misoprostol ranged from 900 to 1800 pesos (US$83-167) for a bottle of 28 tablets (200 mcg each) or US$4.07 per tablet, on average. CONCLUSIONS:Pharmacy workers in both urban and rural areas of Mexico are increasingly becoming aware of misoprostol as an effective abortifacient and are willing to provide the information to consumers. However, their information is limited and often inaccurate. Strategies need to be developed so that they receive timely and correct information, consistent with evidence-based recommendations. The legal context of abortion in Mexico (with restrictions in every state, except Mexico City), the restricted registration of misoprostol as a therapeutic agent only for gastric ulcers and the fact that the majority of pharmacy workers are not considered to be health workers are among the most important barriers to advances in training pharmacy workers in the correct application of misoprostol.

journal_name

Contraception

journal_title

Contraception

authors

Billings DL,Walker D,Mainero del Paso G,Clark KA,Dayananda I

doi

10.1016/j.contraception.2008.12.011

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

445-51

issue

6

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(08)00580-5

journal_volume

79

pub_type

杂志文章
  • Women's perceptions and treatment patterns related to contraception: results of a survey of US women.

    abstract:OBJECTIVES:The aim of this survey was to understand US women's contraception journey from her first prescribed method to her current one including reasons for choosing and stopping/switching methods, healthcare provider relationships, and bleeding preferences. STUDY DESIGN:We administered a nationally-representative, ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.09.010

    authors: Nelson AL,Cohen S,Galitsky A,Hathaway M,Kappus D,Kerolous M,Patel K,Dominguez L

    更新日期:2018-03-01 00:00:00

  • The probability of side effects with ovral, norinyl 1/50 and norlestrin.

    abstract::This report provides specific information on the prevalence rates of the most common side effects during the first 3 cycles of use of 3 combination oral contraceptives (OCs) containing 50 mcg estrogen. The probabilities of a symptom occurring for the first time, or persisting once present, during the initial cycles of...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(79)90050-7

    authors: Berger GS,Edelman DA,Talwar PP

    更新日期:1979-11-01 00:00:00

  • The effect of orally and vaginally administered misoprostol on inflammatory mediators and cervical ripening during early pregnancy.

    abstract:OBJECTIVES:The objective of the present study was to investigate the effect of vaginally and orally administered misoprostol on the local cervical inflammatory response. METHODS:Healthy women with a normal intrauterine pregnancy between 8 and 12 weeks of gestation presenting for an elective termination of pregnancy by...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.contraception.2005.02.012

    authors: Aronsson A,Ulfgren AK,Ståbi B,Stavreus-Evers A,Gemzell-Danielsson K

    更新日期:2005-07-01 00:00:00

  • Cost-effectiveness of treatments for dysfunctional uterine bleeding in women who need contraception.

    abstract:OBJECTIVE:This study aims to compare the cost-effectiveness of oral contraceptives (OCs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and surgical management in treating dysfunctional uterine bleeding (DUB) in women not desiring additional children. METHOD:A Markov model was constructed from the perspec...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2006.03.024

    authors: Blumenthal PD,Trussell J,Singh RH,Guo A,Borenstein J,Dubois RW,Liu Z

    更新日期:2006-09-01 00:00:00

  • Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells.

    abstract::Primary cultures of rat Leydig and Sertoli cells were used to evaluate the direct effects of GTW on testicular cells and to compare these to the effects of gossypol acetate. Both GTW and gossypol acetate can affect the survival of Leydig and Sertoli cells. But Sertoli cells are much more sensitive than Leydig cells, e...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(92)90069-6

    authors: Lan ZJ,Gu ZP,Lu RF,Zhuang LZ

    更新日期:1992-03-01 00:00:00

  • Rebound of medication abortion in Texas following updated mifepristone label.

    abstract:BACKGROUND:In 2013, Texas House Bill 2 (HB 2) placed restrictions on the use of medication abortion, which later were nullified with the 2016 FDA-approved mifepristone label. METHODS:Using data collected directly from Texas abortion facilities, we evaluated changes in the provision and use of medication abortion durin...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.01.001

    authors: Baum SE,White K,Hopkins K,Potter JE,Grossman D

    更新日期:2019-05-01 00:00:00

  • The intensive and extensive margins of contraceptive use: comparing the effects of method choice and method initiation.

    abstract:OBJECTIVES:The risk of pregnancy is estimated to be 20 times as high among women who use oral contraception, and 90 times as high among condom users, as among women who use certain long-acting contraceptive methods. We explored the population-level implications of this variation in contraceptive efficacy. STUDY DESIGN...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2016.03.014

    authors: Thomas A,Karpilow Q

    更新日期:2016-08-01 00:00:00

  • Ovarian cysts: presence and persistence with use of a 13.5mg levonorgestrel-releasing intrauterine system.

    abstract:OBJECTIVE:The aim of this study was to assess the presence of ovarian cysts in women using a new low-dose levonorgestrel-releasing intrauterine contraceptive system (LNG-IUS 13.5mg [total content]). STUDY DESIGN:A Phase 3 study assessed LNG-IUS 13.5mg use in healthy women with regular menstrual cycles who requested co...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2015.01.021

    authors: Nahum GG,Kaunitz AM,Rosen K,Schmelter T,Lynen R

    更新日期:2015-05-01 00:00:00

  • Corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy in simulated uterine fluid.

    abstract::Chemical immersion tests, electrochemical methods and atomic absorption spectrometry were employed to investigate the corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy (SMA) in simulated uterine fluid. The effect of pH on corrosion rate and corrosion potential was also investigated. The results indicated th...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.04.006

    authors: Chen B,Liang C,Fu D,Ren D

    更新日期:2005-09-01 00:00:00

  • Endometrial safety of a novel monophasic combined oral contraceptive containing 0.02 mg ethinylestradiol and 2 mg chlormadinone acetate administered in a 24/4-day regimen over six cycles.

    abstract:BACKGROUND:This study was conducted to examine whether small doses of ethinylestradiol (EE, 0.02 mg) and chlormadinone acetate (CMA, 2 mg) administered in a novel 24/4-day regimen during six cycles would suffice to suppress proliferation and to cause secretory changes in the endometrium. STUDY DESIGN:This Phase II, ra...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2010.04.013

    authors: Rabe T,Hartschuh E,Wahlstrom T,Höschen K,König S

    更新日期:2010-10-01 00:00:00

  • Efficacy and safety of medical abortion using mifepristone and buccal misoprostol through 63 days.

    abstract:OBJECTIVE:The aim of this study was to report on the safety and efficacy of an evidence-based medical abortion regimen utilizing 200 mg of mifepristone orally followed by home use of 800 mcg misoprostol buccally 24-48 h later through 63 days estimated gestational age. STUDY DESIGN:We analyzed outcomes in women present...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.01.005

    authors: Gatter M,Cleland K,Nucatola DL

    更新日期:2015-04-01 00:00:00

  • Post-operative discomfort after ring or clip tubal ligation--is there any difference and do indomethacin suppositories help?

    abstract::One-hundred patients undergoing Falope ring or clip laparoscopic tubal ligation were given either a placebo or a 100 mg indomethacin rectal suppository one hour pre-operatively. Treatment was randomised and double-blind. Post-operative analgesic requirements and side effects were monitored. Forty-seven patients receiv...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(90)90018-q

    authors: MacLennan AH,Rodrigues LV,Krutli DR,Klomp A

    更新日期:1990-09-01 00:00:00

  • Relationship of intraamniotic digoxin to fetal demise.

    abstract:BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasoni...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2009.12.001

    authors: Borgatta L,Betstadt SJ,Reed A,Feng KT

    更新日期:2010-04-01 00:00:00

  • Removal of the LNG IUD when strings are not visible: a case series.

    abstract:OBJECTIVES:To report length of intrauterine device (IUD) and strings as well as technique for extraction when IUD removal occurs without visible strings. STUDY DESIGN:A prospective case series of 29 women who had IUDs removed in-office when strings were not visible at the external cervical os. RESULTS:One third (n=11...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.04.007

    authors: Swenson C,Royer PA,Turok DK,Jacobson JC,Amaral G,Sanders JN

    更新日期:2014-09-01 00:00:00

  • Changing disparities in teen birth rates and repeat birth rates in Georgia: implications for teen pregnancy prevention.

    abstract:OBJECTIVE:To understand teen birth trends in Georgia by racial and geographic factors. STUDY DESIGN:We analyzed overall birth and repeat teen birth rates by race, urban/rural status and adequacy of obstetric care from 2008 to 2016 using vital records from all Georgia counties. RESULTS:Overall birth rates among teens ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.11.007

    authors: Nandi P,Kramer M,Kottke M

    更新日期:2019-03-01 00:00:00

  • Recent intrauterine device use and the risk of precancerous cervical lesions and cervical cancer.

    abstract:OBJECTIVE:Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.04.008

    authors: Averbach S,Silverberg MJ,Leyden W,Smith-McCune K,Raine-Bennett T,Sawaya GF

    更新日期:2018-04-17 00:00:00

  • Dimeric inhibin serum values as markers of ovarian activity in pill-free intervals.

    abstract::Levels of inhibin A and B as well as other hormones in serum samples obtained during the pill-free interval in women taking combined oral contraceptives (OC) were measured to asses the extent of ovarian activity during that period. Type of pill and day of pill-free interval were recorded during routine gynecologic che...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(97)00206-0

    authors: Renier MA,Vereecken A,Van Herck E,Straetmans D,Ramaekers P,Vanderheyden J,Degezelle H,Buytaert P

    更新日期:1998-01-01 00:00:00

  • Ovulation inhibition by a new low-dose progestagen.

    abstract::A new synthetic progestagen, Org 2969 (13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol) was administered to 9 healthy normally menstruating women. 3 subjects (Group 1) ingested .030 mg, while 6 (Group 2) ingested .015 mg of the compound daily on Days 1-20 of 1 menstrual cycle. The previous menstrual...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(77)90129-9

    authors: Viinikka L,Hirvonen E,Ylikorkala O,Nummi S,Virkkunen P,Ranta T,Alapiessa U,Vihko R

    更新日期:1977-07-01 00:00:00

  • Serum prolactin concentrations related to copper or inert intrauterine devices (IUDs) in women.

    abstract::A report that serum prolactin concentrations were almost doubled by the use of copper IUDs led us to study the effect of both copper and inert IUDs. We studied 105 normal women in whom all other prolactinergic factors had been excluded; 25 of them were using copper IUDs, 25 were using inert IUDs and there were 55 cont...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(79)90049-0

    authors: Ransom WT,Chapman RS,Hull MG

    更新日期:1979-11-01 00:00:00

  • Delayed implantation induced by fadrozole hydrochloride in rats.

    abstract::The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of spe...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(03)00076-3

    authors: Tamada H,Mizuta Y,Kawate N,Inaba T,Sawada T

    更新日期:2003-07-01 00:00:00

  • Endometrial estradiol-17 beta-dehydrogenase activity in women wearing Cu-IUD.

    abstract::In order to determine whether inhibition of the endometrial estradiol-17 beta-dehydrogenase activity by Cu++ could be one of the factors accounting for the enhanced contraceptive efficacy of copper intrauterine devices (Cu-IUD), the activity of the enzyme was measured in endometrial biopsies from women wearing this de...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(79)90019-2

    authors: Tseng L,Dramusic V,Gurpide E

    更新日期:1979-03-01 00:00:00

  • A morphometric study of the effect of oral norethisterone or levonorgestrel on endometrial blood vessels.

    abstract::A morphometric study was undertaken to quantitate vessel numbers in uterine biopsies from a control group of patients, patients with dysfunctional uterine bleeding and patients taking low dose norethisterone or levonorgestrel. Vessels were counted at the endometrial/myometrial junction and in the functional endometriu...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(86)80016-6

    authors: Hourihan HM,Sheppard BL,Bonnar J

    更新日期:1986-12-01 00:00:00

  • A study of co-treatment of nonsteroidal anti-inflammatory drugs (NSAIDs) with misoprostol for cervical priming before suction termination of first trimester pregnancy.

    abstract::This double-blind randomized control study was conducted to evaluate whether a nonsteroidal anti-inflammatory drug (NSAID) could act as an effective pain control method during first trimester suction abortion, and whether co-treatment of NSAID with misoprostol will decrease the efficacy of the cervical ripening effect...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(02)00437-7

    authors: Li CF,Wong CY,Chan CP,Ho PC

    更新日期:2003-02-01 00:00:00

  • Pharmacodynamic effects of once-a-month combined injectable contraceptives.

    abstract::The pharmacology and clinical assessment of existing first generation once-a-month combined injectable contraceptives, mainly Deladroxate and Chinese Injectable No. 1, are reviewed. Although these two types of monthly injectables have been used in some million women in China and Latin America, Deladroxate needs indept...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/0010-7824(94)90033-7

    authors: Sang GW

    更新日期:1994-04-01 00:00:00

  • The clinical acceptability of a non-medicated vaginal ring.

    abstract::In an open study the acceptability of a newly designed vaginal ring was evaluated. The ring, being developed for contraceptive purposes, was made of Silastic and did not contain any medication. Three groups of 10 healthy female volunteers were selected after informed consent. The 6 nulliparous and 24 parous women were...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(90)90103-3

    authors: Roumen F,Dieben T,Assendorp R,Bouckaert P

    更新日期:1990-08-01 00:00:00

  • A pilot clinical trial of ultrasound-guided postplacental insertion of a levonorgestrel intrauterine device.

    abstract:BACKGROUND:Postplacental intrauterine device (IUD) insertion is a safe, convenient and effective option for postpartum contraception. Few studies involve ultrasound-guided insertion, and none involve the levonorgestrel IUD or take place in the United States. STUDY DESIGN:The study was conducted to assess the safety an...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2007.06.003

    authors: Hayes JL,Cwiak C,Goedken P,Zieman M

    更新日期:2007-10-01 00:00:00

  • Results and lessons learned from a small medical abortion clinical study in Turkey.

    abstract::This article presents results from a small, introductory clinical study offering a simplified regimen medical abortion to women in Turkey. A total of 208 women from five sites were recruited from July 2000 through March 2001. All eligible consenting women were given 200 mg oral mifepristone at the clinic followed by 4...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2004.05.005

    authors: Akin A,Blum J,Ozalp S,Onderoğlu L,Kirca U,Bilgili N,Koçoğlu G,Philip N,Winikoff B

    更新日期:2004-11-01 00:00:00

  • Progestin-only pill use and pill switching during breastfeeding.

    abstract::The opinions of 20 international experts in reproductive endocrinology and family planning service delivery were solicited concerning contraceptive pill use during breastfeeding and, in particular, to determine whether the experts felt that breastfeeding women who use progestin-only pills (POPs) should be advised to s...

    journal_title:Contraception

    pub_type: 社论

    doi:10.1016/0010-7824(95)00076-m

    authors: Visness CM,Rivera R

    更新日期:1995-05-01 00:00:00

  • Effects of intrauterine contraception on the vaginal microbiota.

    abstract:OBJECTIVES:There have been conflicting reports of altered vaginal microbiota and infection susceptibility associated with contraception use. The objectives of this study were to determine if intrauterine contraception altered the vaginal microbiota and to compare the effects of a copper intrauterine device (Cu-IUD) and...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.05.017

    authors: Bassis CM,Allsworth JE,Wahl HN,Sack DE,Young VB,Bell JD

    更新日期:2017-09-01 00:00:00

  • IUD use among parous women and risk of uterine perforation: a secondary analysis.

    abstract:OBJECTIVE:The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations. STUDY DESIGN:We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definiti...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.03.007

    authors: Heinemann K,Barnett C,Reed S,Möhner S,Do Minh T

    更新日期:2017-06-01 00:00:00