Abstract:
OBJECTIVE:The aim of this study was to report on the safety and efficacy of an evidence-based medical abortion regimen utilizing 200 mg of mifepristone orally followed by home use of 800 mcg misoprostol buccally 24-48 h later through 63 days estimated gestational age. STUDY DESIGN:We analyzed outcomes in women presenting for medical abortion between April 1, 2006, and May 31, 2011, using an evidence-based alternative to the United States Food and Drug Administration (FDA)-approved regimen. Cases were identified for this descriptive study from our electronic practice management (EPM) database, and our electronic database on adverse events was queried for information on efficacy and safety. The primary outcome was successful abortion. Logistic regression was used to identify predictors of successful abortion. RESULTS:Among the 13,373 women who completed follow-up, efficacy of the regimen was 97.7%. Efficacy was highest at 29 to 35 days (98.8%) and 36 to 42 days (98.8%) of gestation and lowest at 57 to 63 days (95.5%). The odds of needing aspiration for any reason were greatest at higher gestational ages. Rates of infection requiring hospitalization and rates of transfusion were 0.01 and 0.03%, respectively. CONCLUSIONS:An evidence-based regimen of 200 mg of mifepristone orally followed by home use of 800 mcg of buccal misoprostol 24-48 h later is safe and effective through 63 days estimated gestational age. Further, the need for aspiration for any reason was low, and hospitalization was rare. IMPLICATIONS:This study reinforces the safety and efficacy of the evidence-based regimen for medical abortion (200 mg mifepristone orally followed by home use of 800 mcg of misoprostol buccally 24-48 h later) through 63 days estimated gestational age, and contributes to the existing evidence against restrictions requiring use of the FDA-approved regimen.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Gatter M,Cleland K,Nucatola DLdoi
10.1016/j.contraception.2015.01.005subject
Has Abstractpub_date
2015-04-01 00:00:00pages
269-73issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(15)00006-2journal_volume
91pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract:OBJECTIVE:To explore health care providers' communication practices during contraceptive counseling for women with substance use disorders (SUDs). STUDY DESIGN:In 2019, we conducted semi-structured phone interviews with a purposive sample of medical doctors and advanced practice nurses (n = 24). A two-member team anal...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.09.002
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The objectives of this analysis were to 1) estimate prevalence of contraceptive use among women at risk for unintended pregnancy and 2) identify correlates of contraceptive use among women with ongoing or potential need for contraceptive services in Puerto Rico during the 2016 Zika virus (ZIKV) outbreak. ST...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.03.001
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The use of progestogen-only contraceptives by breastfeeding women raises theoretical concerns regarding possible adverse effects on breastfeeding success, and infant health or growth. This review was conducted to determine from the literature whether use of progestogen-only contraceptives by breastfeeding wo...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2010.02.002
更新日期:2010-07-01 00:00:00
abstract::Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasia...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2010.03.020
更新日期:2010-11-01 00:00:00
abstract::This randomized, double-blind, placebo-controlled exploratory study examined the efficacy and safety of a low-dose oral contraceptive (Mircette), desogestrel/ethinyl estradiol [DSG/EE] and ethinyl estradiol [EE]) in relieving the symptoms of dysmenorrhea. Twenty-three clinics in the United States enrolled 77 women (ag...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(02)00414-6
更新日期:2002-12-01 00:00:00
abstract::In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(80)80001-1
更新日期:1980-09-01 00:00:00
abstract::The possibility of permanent sterility following use of modern contraceptive agents is a concept which causes great concern amongst members of the lay public. However, a thorough review of the literature gives a great deal of reassurance on this topic. The combined oral contraceptive pill causes slight delay, and the ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(82)90105-6
更新日期:1982-10-01 00:00:00
abstract:OBJECTIVES:Federally Qualified Health Centers (FQHCs) are a major and growing source of primary care for low-income women of reproductive age; however, only limited knowledge exists on the scope of family planning care they provide and the mechanisms for delivery of these essential reproductive health services, includi...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.09.015
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:To document the experience of three groups of Family Planning service providers participating in task-shifting for the provision of subcutaneous depot-medroxyprogesterone acetate (DMPA-SC) at the community level in the DRC. STUDY DESIGN:This article compares results from interviews with DMPA-SC providers in...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.07.002
更新日期:2018-11-01 00:00:00
abstract::Patterns of bleeding and plasma concentrations of levonorgestrel, progesterone, estradiol, LH and FSH were studied in ten volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. The IUD was designed to release 12 microgram/day. All but two of the volunteers ovulated during treatment. The ovulatory ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90127-4
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Hypertension is recognized as a major risk factor for coronary, cerebral and renal vascular disease. Hormonal methods of contraception may increase the risk for cardiovascular events. We evaluated whether the combined hormonal contraceptive vaginal ring that releases 15-mcg ethinylestradiol and 120 mcg of et...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.04.003
更新日期:2013-10-01 00:00:00
abstract::STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone ad...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90140-7
更新日期:1980-01-01 00:00:00
abstract::Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were monitored weekly for a period of 12 weeks by measuring 3 pituitary hormones (FSH, LH and prolactin) and 2 ovarian hormones (oestradiol 17-B and progesterone). It was concluded that NET-OEN is a...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(83)80004-3
更新日期:1983-07-01 00:00:00
abstract::This was a double-blind randomized control study to evaluate the efficacy of cervical priming by nitric oxide donor before second-trimester induced abortion. One-hundred healthy women with a singleton pregnancy between 14 and 20 weeks of gestation were randomized into either 40 mg isosorbide mononitrate or placebo, gi...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(03)00170-7
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Contraceptive prevalence is relatively low in Albania, and abortion is the mainstay of family planning. Although levonorgestrel-only emergency contraceptive pills are available, uptake of this method is minimal. Emergency contraception (EC) could play a significant role in addressing women's need for an effe...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.03.033
更新日期:2018-04-11 00:00:00
abstract::Mifepristone medical abortion has been a valuable addition to the reproductive health options of women. Aspects of its provision have however sometimes limited its accessibility and use. This article summarizes existing evidence for simplifying the provision of medical abortion and thus increasing its availability. We...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2006.11.011
更新日期:2007-04-01 00:00:00
abstract::In an open study the acceptability of a newly designed vaginal ring was evaluated. The ring, being developed for contraceptive purposes, was made of Silastic and did not contain any medication. Three groups of 10 healthy female volunteers were selected after informed consent. The 6 nulliparous and 24 parous women were...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(90)90103-3
更新日期:1990-08-01 00:00:00
abstract::In Lebanon, coitus interruptus or withdrawal remains a widely practiced method of family planning. Our research sought to understand the role of men in reproductive health in Lebanon by focusing on this common practice. Our main questions were: Why is it that the practice persists when more effective modern methods of...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00304-3
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:This study aims to clarify the associations between mobile phone ownership use on family planning outcomes. Secondary analysis of DHS data finds that in certain contexts, mobile phone ownership may be related to increased FP uptake. STUDY DESIGN:Using recent data for women 15-49 from the Demographic and Hea...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.10.004
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Concern about pain during placement of an intrauterine device (IUD) represents a barrier to use, especially among nulliparous women. We hypothesized that nitroglycerin gel applied vaginally 30 min prior to IUD placement would reduce insertion-related pain. STUDY DESIGN:We designed a randomized, double-blinde...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2014.03.012
更新日期:2014-07-01 00:00:00
abstract::A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90038-0
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations. STUDY DESIGN:We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definiti...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.03.007
更新日期:2017-06-01 00:00:00
abstract::The aim of this guidance is to review the management of unacceptable vaginal bleeding patterns in etonogestrel (ENG)-releasing contraceptive implant users concentrating, where possible, on the evidence for pharmacological treatments and identifying a pragmatic approach where this is not possible. This article was deve...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2010.08.001
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:This study was conducted to examine whether small doses of ethinylestradiol (EE, 0.02 mg) and chlormadinone acetate (CMA, 2 mg) administered in a novel 24/4-day regimen during six cycles would suffice to suppress proliferation and to cause secretory changes in the endometrium. STUDY DESIGN:This Phase II, ra...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2010.04.013
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Experimental evidences suggest that metabolic activation and conversion of oral contraceptive pills (OCPs) to reactive species are responsible for their genotoxicity. The present study was undertaken to investigate the effects of low-dose (LD) OCPs on the activities of erythrocyte antioxidant enzymes glutath...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.07.026
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:There have been conflicting reports of altered vaginal microbiota and infection susceptibility associated with contraception use. The objectives of this study were to determine if intrauterine contraception altered the vaginal microbiota and to compare the effects of a copper intrauterine device (Cu-IUD) and...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.05.017
更新日期:2017-09-01 00:00:00
abstract::Postpartum contraceptive decision making is complex, and recommendations may be influenced by breastfeeding intentions. While biologically plausible, concerns about the adverse impact of hormonal contraception on breast milk production have not been supported by the clinical evidence to date. However, the data have li...
journal_title:Contraception
pub_type: 社论
doi:10.1016/j.contraception.2018.10.011
更新日期:2019-02-01 00:00:00
abstract::A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(89)80004-6
更新日期:1989-02-01 00:00:00
abstract::Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were measured in seven volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. Blood samples were collected twice weekly during a mean of 93 days immediately postmenstrually and during a mean of 41 days over the twelfth to...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90003-7
更新日期:1980-03-01 00:00:00
abstract::Twenty patients undergoing elective midtrimester abortion by urea amnioinfusion had bacteriologic culture data obtained before and after the procedure. Despite the presence of pathogens in the vagina and cervix prior to the procedure, only 20% of patients exhibited endometrial growth following abortion. Factors that s...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(78)80002-x
更新日期:1978-06-01 00:00:00