Clinical trials in male hormonal contraception.

Abstract:

:Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasians, additional agents are required of which progestins are favored. Clinical trials concentrate on testosterone combined with norethisterone, desogestrel, etonogestrel or depot-medroxyprogesterone acetate. The first randomized, placebo-controlled clinical trial performed by the pharmaceutical industry demonstrated the effectiveness of a combination of testosterone undecanoate and etonogestrel in suppressing spermatogenesis in volunteers.

journal_name

Contraception

journal_title

Contraception

authors

Nieschlag E

doi

10.1016/j.contraception.2010.03.020

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

457-70

issue

5

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(10)00137-X

journal_volume

82

pub_type

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