Abstract:
:Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasians, additional agents are required of which progestins are favored. Clinical trials concentrate on testosterone combined with norethisterone, desogestrel, etonogestrel or depot-medroxyprogesterone acetate. The first randomized, placebo-controlled clinical trial performed by the pharmaceutical industry demonstrated the effectiveness of a combination of testosterone undecanoate and etonogestrel in suppressing spermatogenesis in volunteers.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Nieschlag Edoi
10.1016/j.contraception.2010.03.020subject
Has Abstractpub_date
2010-11-01 00:00:00pages
457-70issue
5eissn
0010-7824issn
1879-0518pii
S0010-7824(10)00137-Xjournal_volume
82pub_type
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