Abstract：
:Benzene extractives of Hibiscus rosa-sinensis flowers, administered during day 1-4 of gestation, exerted anti-implantation effect without affecting the tubal transport of zygote. On day 4, normal number of blastocyst was present in the uterus but they did not implant. However, as studied by pontamine blue reaction, it was evident that hyper-permeability of the endometrial capillaries which is the earliest known response of a receptive endometrium to any kind of deciduogenic stimulus was inhibited by the extract. The magnitude of decidualization, as assessed by weight of the traumatized uterine horn and supported by the histological pictures of the uteri was significantly lower in comparison to that of the controls. Ovarian structure exhibited signs of luteolysis. Inadequate progestational development of the endometrium due to interference with the conditioning of the uterus with progesterone during prenidatory phase of pregnancy has been suggested as the plausible cause of the extract-induced implantation failure.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Pal AK,Bhattacharya K,Kabir SN,Pakrashi Adoi
10.1016/0010-7824(85)90021-6subject
Has Abstractpub_date
1985-11-01 00:00:00pages
517-29issue
5eissn
0010-7824issn
1879-0518pii
0010-7824(85)90021-6journal_volume
32pub_type
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