Abstract:
OBJECTIVE:Concern about pain during placement of an intrauterine device (IUD) represents a barrier to use, especially among nulliparous women. We hypothesized that nitroglycerin gel applied vaginally 30 min prior to IUD placement would reduce insertion-related pain. STUDY DESIGN:We designed a randomized, double-blinded, placebo-controlled pilot study to evaluate the efficacy and tolerability of 0.5-mg nitroglycerin gel (1 mL) or identical placebo gel applied vaginally in nulliparous women 30 min prior to IUD placement. The study was limited to women who opted for the levonorgestrel-releasing intrauterine system. Subjects completed a series of 100-mm visual analogue scales at several time points. The primary outcome was subject-reported pain with passage of the IUD through the cervix. Secondary outcomes included subject-reported pain at other time points, provider-reported ease of insertion, side effects, adverse events and need for additional dilation. RESULTS:A total of 24 women were randomized. Baseline characteristics were similar between groups. The mean pain score with IUD deployment was 55.0 mm [standard deviation (SD) = 29.7 mm] in the placebo group and 57.4 mm (SD 22.1 mm) in the nitroglycerin group (p=.82). There was no difference in ease of insertion reported by providers. Two subjects required dilation, one in each group. CONCLUSION:Vaginal administration of 0.5-mg nitroglycerin gel 30 min prior to IUD placement does not appear to decrease patient-reported procedural pain among nulliparous women or ease of insertion for providers.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Micks EA,Jensen JT,Bednarek PHdoi
10.1016/j.contraception.2014.03.012subject
Has Abstractpub_date
2014-07-01 00:00:00pages
60-5issue
1eissn
0010-7824issn
1879-0518pii
S0010-7824(14)00145-0journal_volume
90pub_type
杂志文章,随机对照试验相关文献
CONTRACEPTION文献大全abstract:OBJECTIVE:To assess the cost-effectiveness of self-injected subcutaneous depot medroxyprogesterone acetate (DMPA-SC) compared to health-worker-administered intramuscular DMPA (DMPA-IM) in Uganda. STUDY DESIGN:We developed a decision-tree model with a 12-month time horizon for a hypothetical cohort of approximately 1 m...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.07.137
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Determine if erythromycin is an effective agent for achieving occlusion of the Fallopian tube for nonsurgical female sterilization. METHODS:Two studies of 100 healthy volunteers requesting sterilization were planned, one in Julpia Andhermanik and the other in Kolkata (Calcutta). A readily available marketed ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2003.07.005
更新日期:2004-01-01 00:00:00
abstract::The efficacy of administering an antibiotic prior to IUD insertion to reduce the risk of introducing an upper genital tract infection during the procedure has not yet been established. Two double-blind randomized studies conducted in Africa comparing a 200 mg prophylactic dose of doxycycline with a placebo did not con...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(94)90019-1
更新日期:1994-10-01 00:00:00
abstract::Twenty normotensive and ten hypertensive black women taking oral contraceptive (OC) were studied. Age, body weight, family medical history of hypertension, length of OC use, and type of OC were comparable. At midcycle approximately 10-12 hours following OC intake, blood was drawn and the plasma was used to determine e...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(81)80006-6
更新日期:1981-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to explore the relationship between oral contraceptive pill (OCP) use and the experience of depressive symptoms among a representative sample of young Australian women. METHODS:The study sample comes from the Australian Longitudinal Study on Women's Health. Analysis was confined t...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2006.08.002
更新日期:2007-01-01 00:00:00
abstract::The ability of the condom wall to maintain its integrity throughout sexual intercourse is critical to its role in halting the spread of major sexually transmissible pathogens including the human immunodeficiency virus. There are three principal in vitro performance tests applied to condoms: a test for freedom from hol...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(91)90045-h
更新日期:1991-02-01 00:00:00
abstract::Although weight gain is among the most common complaints of women using oral contraceptives (OC) and a frequent reason for discontinuation, studies demonstrate little basis for this perception. We explored this issue by analyzing the daily weights of 128 women during four cycles of triphasic OC use. The mean weight at...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(98)00127-9
更新日期:1998-12-01 00:00:00
abstract::The concentration of FSH, LH, testosterone and sperm agglutinating and cytotoxic antibodies have been determined in 87 men at varying time intervals after vasectomy. The results indicated that vasectomy is not associated with statistically significant changes in any of these parameters. Furthermore, no correlation exi...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(79)90007-6
更新日期:1979-06-01 00:00:00
abstract:OBJECTIVES:We aimed to qualitatively evaluate factors that contribute to and alleviate grief associated with termination of a pregnancy for a fetal anomaly and how that grief changes over time. STUDY DESIGN:We conducted a longitudinal qualitative study of decision satisfaction, grief and coping among women undergoing ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.11.015
更新日期:2015-03-01 00:00:00
abstract::Adult female rats were given a single, subcutaneous injection of 8, 16 or 32 micrograms of levonorgestrel (LNG). Blood samples were collected at various time intervals and serum concentrations of LNG were determined by radioimmunoassay. The patterns of temporal decline in LNG concentrations in the three dose groups in...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(84)90009-x
更新日期:1984-12-01 00:00:00
abstract::In a prospective double-blind study of the effects of two low-dose oral contraceptives (OCs) on lipid and lipoprotein metabolism, two groups of eighteen young healthy women selected at random were submitted to a six months' use of either monophasic ethinylestradiol (EE) + desogestrel (DG) or triphasic EE + levonorgest...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(88)90003-0
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Given the need for a 90-day post-Essure hysterosalpingogram (HSG) to confirm proper tubal placement and occlusion, we examined the impact of dedicating a staff nurse to schedule HSG appointments, call with appointment reminders and track HSG compliance for patients who had Essure. STUDY DESIGN:We performed ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.01.019
更新日期:2010-06-01 00:00:00
abstract::This paper presents a secondary analysis of 3419 Norplant users from 11 countries throughout Asia, Africa and Latin America. The main objective was to identify the menstrual problems associated with a high risk of early discontinuation of Norplant use. Eligible participants were divided into two groups: those who cont...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(03)00040-4
更新日期:2003-05-01 00:00:00
abstract::A method based on HPLC was devised for the estimation of RU 486 in blood and utilised to study the pharmacokinetics of a single dose of 50 mg RU 486 administered orally to 12 women on day 7 of the cycle. The dose was rapidly absorbed with peak plasma concentration between 1 and 2 hours. Distribution was also rapid (me...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90052-8
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVE:To understand teen birth trends in Georgia by racial and geographic factors. STUDY DESIGN:We analyzed overall birth and repeat teen birth rates by race, urban/rural status and adequacy of obstetric care from 2008 to 2016 using vital records from all Georgia counties. RESULTS:Overall birth rates among teens ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.11.007
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:The objective was to describe the efficacy of medical abortion using mifepristone and misoprostol for gestations less than 6 weeks. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of mifepristone and misoprostol abortion at gestational ages <42 da...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.09.006
更新日期:2018-02-01 00:00:00
abstract::The pharmacokinetics and androgenic activity of Estrostep, a new oral contraceptive providing low-dose estrogen in a graduated sequence with a constant dose of progestin, were characterized in an open-label, nonrandomized study in 17 normally cycling women treated for three cycles with Estrostep. Women received 1 mg o...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(01)00179-2
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:To compare pain levels and medication needs after placement of laminaria vs Dilapan-S, and after dilation and evacuation (D&E). STUDY DESIGN:We conducted a single-blinded randomized control trial of patients undergoing D&E at 15 0/7 to 23 6/7 weeks gestation, randomizing to cervical preparation with laminar...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.11.014
更新日期:2020-12-04 00:00:00
abstract::This report provides specific information on the prevalence rates of the most common side effects during the first 3 cycles of use of 3 combination oral contraceptives (OCs) containing 50 mcg estrogen. The probabilities of a symptom occurring for the first time, or persisting once present, during the initial cycles of...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(79)90050-7
更新日期:1979-11-01 00:00:00
abstract::All intrauterine devices (IUDs) that have been tested experimentally or clinically induce a local inflammatory reaction of the endometrium whose cellular and humoral components are expressed in the tissue and the fluid filling the uterine cavity. Depending on the reproductive strategy of the species considered and the...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2007.01.020
更新日期:2007-06-01 00:00:00
abstract::This report describes the long-term follow-up of 376 women who received NORPLANT implants in the period October 1974 through May 1979. One-hundred-and-ten subjects received replacement implants after variable lengths of use of the first set. The average levonorgestrel plasma levels declined steadily through eight year...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(87)80016-1
更新日期:1987-06-01 00:00:00
abstract::Surveys undertaken in the 1970s and 1980s suggested that amenorrhea was unacceptable to most women, especially in developing countries. More recent research suggests that increasing numbers of women in the developed world prefer to menstruate less often. In a questionnaire survey of 1001 women attending family-plannin...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/s0010-7824(02)00474-2
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Potential barriers to intrauterine device (IUD) use include provider concern about difficult insertion, particularly for nulliparous women. OBJECTIVE:This study aims to evaluate the evidence on the effectiveness of medications to ease IUD insertion on provider outcomes (i.e., ease of insertion, need for adj...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2016.06.014
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to measure the accessibility to purchase oral and transdermal contraceptives over the Internet for low- and high-risk individuals. METHODS:The Internet was used to search for and order both oral and transdermal contraceptives. Using the "Google" search engine to locate online pha...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.10.001
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.06.004
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Detection of semen biomarkers in vaginal fluid can be used to assess women's recent exposure to semen. Quantitative tests for detection of prostate-specific antigen (PSA) perform well, but are expensive and require specialized equipment. We assessed two rapid immunochromatographic strip tests for identificat...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.02.022
更新日期:2010-09-01 00:00:00
abstract::A non-randomized comparative clinical trial of the progestin-only oral contraceptive (POC), Ovrette (75 mcg norgestrel) (Wyeth), versus non-hormonal methods was conducted at two clinics in Buenos Aires, Argentina. The trial was designed to assess the breast-feeding patterns of women choosing progestin-only oral contra...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(91)90104-n
更新日期:1991-07-01 00:00:00
abstract::Mifepristone-induced abortion is increasingly common. Recent alerts have highlighted the occurrence of infrequent but serious complications. We report a case of serious bacterial infection after medical termination that occurred in the absence of the usual signs of infection. ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.09.003
更新日期:2006-04-01 00:00:00
abstract::California is home to more than one out of eight American women of reproductive age. Because California has a large, diverse and growing population, national statistics do not necessarily describe the reproductive health of California women. This article presents risk for pregnancy and sexually transmitted infections ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.01.012
更新日期:2004-07-01 00:00:00
abstract::Users of subdermal contraceptive implants report long duration of use, convenience, and high efficacy as liked features and bleeding irregularities, weight loss/gain, and headaches as disliked effects of these methods. Satisfied users tend to be women who do not experience side effects or women who value positive feat...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/s0010-7824(01)00281-5
更新日期:2002-01-01 00:00:00