Patterns of ovulation and bleeding with a low levonorgestrel-releasing intrauterine device.

Abstract:

:Patterns of bleeding and plasma concentrations of levonorgestrel, progesterone, estradiol, LH and FSH were studied in ten volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. The IUD was designed to release 12 microgram/day. All but two of the volunteers ovulated during treatment. The ovulatory cycles differed from the control cycles by being longer and by having depressed plasma progesterone levels during the luteal phases. Intermenstrual spottings occurred frequently during the first sixty days of treatment. No pregnancies occurred during the course of the study. :10 women between 23 and 34 years old had a levonorgestrel-releasing IUD inserted bwtween the 3rd and 9th day of their cycle to determine bleeding patterns, LH and FSH levels as well as levonorgestrel, progesterone, and estradiol levels. The IUD released 12 ug/day with side effects including intermenstrual spotting for approximately 3 months in all 10 women, lack of ovulation which occurred in 2 women, lengthened cycles, and low progesterone concentrations in the luteal phase. No pregnancies were reported during the study; however, if the daily release rate of levonorgestrel is reduced to eliminate effects on ovulation, the risk of pregnancy would increase.

journal_name

Contraception

journal_title

Contraception

authors

Nilsson CG,Lähteenmäki P,Luukkainen T

doi

10.1016/0010-7824(80)90127-4

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

155-64

issue

2

eissn

0010-7824

issn

1879-0518

pii

0010-7824(80)90127-4

journal_volume

21

pub_type

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