当前位置： SCI文献检索 > CONTRACEPTION期刊下所有文献 > Plasma lipoproteins and fatty acid composition after "minipill".

Plasma lipoproteins and fatty acid composition after "minipill".

Abstract：

:A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six months of treatment. All together, total cholesterol concentration did not vary; however, the high cholesterol values decreased whereas the low cholesterol values increased with the pill. Triglyceride levels increased significantly (p less than 0.001). High density lipoprotein (HDL)-cholesterol decreased clearly (p less than 0.001) regardless of the cholesterol value at the beginning; low and very low density lipoprotein (LDL + VLDL)-cholesterol increased slightly, as well as the apoprotein B (Apo B) concentration (p less than 0.05). The lipoprotein electrophoresis showed intermediate bands (IDL) in 5/12 of the women after treatment. The three major classes of lipoprotein showed some variations in the fatty acid composition after the oral contraceptive; in any lipid class from any lipoprotein, the linoleic (18: 1 omega 6), arachidonic (20: 4 omega 6) and eicosapentaenoic (20: 5 omega 3) acids decreased whereas the palmitic (16: 0) and oleic (18: 1 omega 9) acids increased. Our results suggest that a low-dose contraceptive like Adepal produces, nevertheless, some significative modifications of plasma lipids and lipoproteins. :A study of the effect of a low-dose oral contraceptive (OC; Adepal--ethinyl estradiol and levonorgestrel), given in doses of 30 and 150 mcg on days 5-12, 40 and 200 mcg on days 13-28, on blood lipids, lipoproteins, and fatty acid composition has been conducted on 13 young women before and after 6 months of treatment. All together, total cholesterol concentration did not vary; however, the high cholesterol values decreased whereas the low cholesterol values increased with the pill. Triglyceride levels increased significantly (p0.001). High density lipoprotein-cholesterol decreased clearly (p0.001), regardless of the cholesterol value at the beginning; low and very low density lipoprotein-cholesterol increased slightly, as well as the apoprotein B concentration (p0.05). The lipoprotein electrophoresis showed intermediate bands in 5/12 of the women after treatment. The 3 major classes of lipoprotein showed some variations in the fatty acid composition after the OC; in any lipid class from any lipoprotein, the linoleic acid (18: 1 omega 6), arachidonic (20: 4 omega 6), and eicosapentaenoic (20: 5 omega 3) acids decreased whereas the palmitic (16: 0) and oleic (18: 1 omega 9) acids increased. Results suggest that a low-dose contraceptive like Adepal produces, nevertheless, some significant modifications in plasma lipids and lipoproteins.

journal_name

Contraception

journal_title

Contraception

authors

Sassolas A,Lagarde M,Guichardant M,Quincy C,Dechavanne M

doi

10.1016/0010-7824(83)90038-0

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

357-68

issue

4

eissn

0010-7824

issn

1879-0518

pii

0010-7824(83)90038-0

journal_volume

28

pub_type

杂志文章

相关文献

CONTRACEPTION文献大全
  • Effect of an oral contraceptive in primary dysmenorrhea--changes in uterine activity and reactivity to agonists.

    abstract：:Mechanisms for the therapeutic effect of oral contraceptives in dysmenorrhea were studied by recording intrauterine pressure on the first day of menstrual bleeding in women with moderate to severe symptoms and after three weeks of oral contraceptive therapy (150 micrograms levonorgestrel + 30 micrograms ethinyl estrad...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(89)90026-7

    authors： Ekström P,Juchnicka E,Laudanski T,Akerlund M

    更新日期：1989-07-01 00:00:00

  • A study of the relationship between tensile testing of condoms and breakage in use.

    abstract：:The ability of the condom wall to maintain its integrity throughout sexual intercourse is critical to its role in halting the spread of major sexually transmissible pathogens including the human immunodeficiency virus. There are three principal in vitro performance tests applied to condoms: a test for freedom from hol...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(91)90045-h

    authors： Gerofi J,Shelley G,Donovan B

    更新日期：1991-02-01 00:00:00

  • Cardiovascular risk factors in Norwegian women using oral contraceptives: results from a cardiovascular health screening 1985-88.

    abstract：:We analyzed data from 4,905 women aged 20-39 and 14,803 aged 40-49 who attended a health survey in Norway 1985-88, to study cardiovascular risk factors in users of oral contraceptives, all types and specifically by formulation. In age group 20-39, users of low-dose estrogen/ progestin regimens were younger, had lower ...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(96)00082-0

    authors： Graff-Iversen S,Tverdal A,Stensvold I

    更新日期：1996-06-01 00:00:00

  • Contraceptive failure in the United States.

    abstract：:This review provides an update of previous estimates of first-year probabilities of contraceptive failure for all methods of contraception available in the United States. Estimates are provided of probabilities of failure during typical use (which includes both incorrect and inconsistent use) and during perfect use (c...

    journal_title：Contraception

    pub_type： 杂志文章,评审

    doi：10.1016/j.contraception.2011.01.021

    authors： Trussell J

    更新日期：2011-05-01 00:00:00

  • Latin american experience with two low-dose oral contraceptives containing 30 microg ethinylestradiol/75 microg gestodene and 20 microg ethinylestradiol/150 microg desogestrel.

    abstract：:The objective of this study was to compare cycle control, efficacy and tolerance of an oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel with a preparation containing 30 microg ethinylestradiol combined with 75 microg gestodene. This study involved 342 women and 4104 cycles use in Arg...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0010-7824(00)00153-0

    authors： Bassol S,Alvarado A,Celis C,Cravioto MC,Peralta O,Montaño R,Novelli J,Albornoz H,Kesseru E,Soares A,Petracco A,Isaia B,Mendes J,Bahamondes L,de Melo NR,Reyes-Marquez R,Albrecht G

    更新日期：2000-09-01 00:00:00

  • Use of Norplant implants in a New York City clinic population.

    abstract：:Two-hundred-eight women attending family planning clinics in New York City who received the Norplant contraceptive system during the first sixteen months of Norplant implants insertions were evaluated. Within this clinic population, Norplant implants were a popular contraceptive choice and were removed from 64 of the ...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(94)90096-5

    authors： Gerber S,Westhoff C,Lopez M,Gordon L

    更新日期：1994-06-01 00:00:00

  • Comparative cross-over pharmacokinetic study on two types of postcoital contraceptive tablets containing levonorgestrel.

    abstract：:A pharmaceutical and pharmacokinetic study was carried out on levonorgestrel tablets from two different sources (Hungarian- and Chinese-made). Both preparations contained 0.75 mg levonorgestrel and had been shown to have similar contraceptive efficacy and side effects when used for postcoital contraception. Absorption...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0010-7824(90)90064-3

    authors： He CH,Shi YE,Liao DL,Zhu YH,Xu JQ,Matlin SA,Vince PM,Fotherby K,Van Look PF

    更新日期：1990-05-01 00:00:00

  • Mifepristone-misoprostol versus misoprostol-alone regimen for medication abortion at ≥24 weeks' gestation.

    abstract：OBJECTIVE:To compare time from misoprostol initiation to fetal expulsion for mifepristone-misoprostol versus misoprostol-alone regimens of medication abortion performed at ≥24 weeks' gestation. STUDY DESIGN:We conducted a retrospective study of medication abortion performed at ≥24 weeks' gestation between May 2016 and...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/j.contraception.2020.05.001

    authors： Wingo E,Raifman S,Landau C,Sella S,Grossman D

    更新日期：2020-08-01 00:00:00

  • Effect of a once weekly oral contraceptive upon gonadotrophin and gonadal steroid levels.

    abstract：:A moderately effective oral progestogen contraceptive, R-2323 (13beta-ethyl-17alpha-ethynyl-17-hydroxy-gona-4,9,11-trien,3-one), was administered weekly in doses of 2.5 mg and 5 mg to 5 subjects each for 8 weeks. In 2 of the 10 treatment cycles of 2.5 mg and 4 of the 10 treatment cycles of 5 mg, progesterone levels i...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(74)90071-7

    authors： Tredway DR,Mishell DR Jr

    更新日期：1974-08-01 00:00:00

  • The effect of levonorgestrel-releasing intrauterine device on menorrhagia in women taking anticoagulant medication after cardiac valve replacement.

    abstract：BACKGROUND:This study was conducted to evaluate the effect of levonorgestrel-releasing intrauterine devices (LNG-IUDs) on menorrhagia in patients receiving anticoagulant therapy after cardiac valve replacement. STUDY DESIGN:Forty women with menorrhagia who underwent cardiac valve replacement and were taking anticoagul...

    journal_title：Contraception

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.contraception.2009.02.007

    authors： Kilic S,Yuksel B,Doganay M,Bardakci H,Akinsu F,Uzunlar O,Mollamahutoglu L

    更新日期：2009-08-01 00:00:00

  • Contraceptive efficacy of antimicrobial peptide Nisin: in vitro and in vivo studies.

    abstract：:Sexually transmitted infections and unplanned pregnancies present a great risk to the reproductive health of women. Therefore, female-controlled vaginal products directed toward disease prevention and contraception are needed urgently. In the present study, efforts were made to evaluate the contraceptive potential of ...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/j.contraception.2003.11.002

    authors： Aranha C,Gupta S,Reddy KV

    更新日期：2004-04-01 00:00:00

  • Steroid contraceptives in non-human primates (II). Metabolic fate of synthetic estrogens in the baboon after exposure to oral contraceptives.

    abstract：:The metabolism of isotopically labeled ethinyl estradiol (EE) and mestranol (ME) was studied in 3 baboons before and after the simultaneous injection of a norethindrone-mestranol contraceptive formulation. 6 days after the administration of tritiated-EE and carbon-14-ME, the mean urinary excretion of labeled-EE was 3...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(77)90116-0

    authors： Kulkarni BD,Avila TD,O'Leary JA

    更新日期：1977-03-01 00:00:00

  • Post-operative discomfort after ring or clip tubal ligation--is there any difference and do indomethacin suppositories help?

    abstract：:One-hundred patients undergoing Falope ring or clip laparoscopic tubal ligation were given either a placebo or a 100 mg indomethacin rectal suppository one hour pre-operatively. Treatment was randomised and double-blind. Post-operative analgesic requirements and side effects were monitored. Forty-seven patients receiv...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0010-7824(90)90018-q

    authors： MacLennan AH,Rodrigues LV,Krutli DR,Klomp A

    更新日期：1990-09-01 00:00:00

  • Characteristics of scheduled bleeding manipulation with combined hormonal contraception in university students.

    abstract：BACKGROUND:There is a lack of information concerning the decision factors and sources of information influencing women who purposefully deviate from the prescribed use of their combined hormone contraceptives to exert elective control of their scheduled bleeding. STUDY DESIGN:A self-administered email survey of schedu...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/j.contraception.2012.12.012

    authors： Lakehomer H,Kaplan PF,Wozniak DG,Minson CT

    更新日期：2013-09-01 00:00:00

  • Pregnancy outcomes associated with extended use of the 52-mg 20 μg/day levonorgestrel-releasing intrauterine system beyond 60 months: A chart review of 776 women in Brazil.

    abstract：OBJECTIVE:To assess the contraceptive performance of the 52-mg 20 μg/day levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena; Bayer Oy, Turku, Finland) among women who maintain the same device without changes after 60 months. STUDY DESIGN:This is a chart review study in which we assessed the charts of 766 wo...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/j.contraception.2017.10.007

    authors： Bahamondes L,Fernandes A,Bahamondes MV,Juliato CT,Ali M,Monteiro I

    更新日期：2018-03-01 00:00:00

  • Smoking and oral contraceptive continuation.

    abstract：BACKGROUND:Smoking may be related to early discontinuation of oral contraceptives (OC). STUDY DESIGN:This was a planned secondary analysis of a randomized clinical trial. Women aged less than 25 initiating OC at three inner-city publicly funded family planning clinics enrolled in the study. Subjects reported smoking s...

    journal_title：Contraception

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.contraception.2008.12.003

    authors： Westhoff C,Jones K,Robilotto C,Heartwell S,Edwards S,Zieman M,Cushman L

    更新日期：2009-05-01 00:00:00

  • A twelve-month comparative clinical investigation of two low-dose oral contraceptives containing 20 micrograms ethinylestradiol/75 micrograms gestodene and 30 micrograms ethinylestradiol/75 micrograms gestodene, with respect to efficacy, cycle control, an

    abstract：:The aim of this study was to compare contraceptive reliability, cycle control, and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol (EE2) and 75 micrograms gestodene (GSD), with a reference preparation containing a similar dose of gestodene but in combination with 30 micrograms ethinylestra...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0010-7824(97)00025-5

    authors： Endrikat J,Müller U,Düsterberg B

    更新日期：1997-03-01 00:00:00

  • The anti-glycolytic activity of 3-bromopyruvate on mature boar spermatozoa in vitro.

    abstract：:Mature epididymal boar spermatozoa converted fructose, glycerol and glycerol-3-phosphate to carbon dioxide, but in the presence of 0.5 mM 3-bromopyruvate, these oxidations were inhibited while that of lactate was unaffected. Inhibition of the oxidation of these substrates results in a decrease in the content of ATP an...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(95)00217-x

    authors： Jones AR,Gillan L,Milmlow D

    更新日期：1995-11-01 00:00:00

  • Contraceptive knowledge and use among low-income Hispanic immigrant women and non-Hispanic women.

    abstract：BACKGROUND:With the rising influx of Hispanics to the United States, there is an ongoing need to promote health and wellness care to this non-English-speaking, minority population group. Programs, specifically developed to address the unique cultural mores of Hispanics, need to focus on increasing knowledge about healt...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/j.contraception.2007.12.008

    authors： Garcés-Palacio IC,Altarac M,Scarinci IC

    更新日期：2008-04-01 00:00:00

  • Endometrial histology and progesterone levels in women using norethindrone acetate implants for contraception.

    abstract：:The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(78)90066-5

    authors： Takkar D,Jeyaseelan S,Kinra G,Laumas KR,Hingorani V

    更新日期：1978-02-01 00:00:00

  • Development of a low-dose monthly injectable contraceptive system: II. Pharmacokinetic and pharmacodynamic studies.

    abstract：:A drug delivery system which provides a sustained release of norethindrone (NET) and mestranol (ME) for one month after a single intramuscular injection was assessed as a long-acting injectable contraceptive. The system is based upon well defined particle size crystals of the synthetic steroids maintained in suspensio...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(87)90051-5

    authors： Díaz-Sánchez V,Garza-Flores J,Jimenéz-Thomas S,Rudel HW

    更新日期：1987-01-01 00:00:00

  • Differential regulation of endogenous pro-inflammatory cytokine genes by medroxyprogesterone acetate and norethisterone acetate in cell lines of the female genital tract.

    abstract：BACKGROUND:Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives are widely used in female reproductive therapy, but little is known about their mechanisms of action via steroid receptors in the female genital tract. MPA used as a contraceptive has been implicated in effects on local immune fun...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/j.contraception.2011.06.006

    authors： Africander D,Louw R,Verhoog N,Noeth D,Hapgood JP

    更新日期：2011-10-01 00:00:00

  • Advancing non-directive pregnancy options counseling skills: A pilot Study on the use of blended learning with an online module and simulation.

    abstract：OBJECTIVE:Limitations on didactic time pose barriers to teaching non-directive pregnancy options counseling. This study set out to explore the use of an online module to support trainee performance in a pregnancy options counseling standardized-patient exercise implemented among third-year medical students, and to exam...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/j.contraception.2016.03.005

    authors： Lupi C,Ward-Peterson M,Chang W

    更新日期：2016-10-01 00:00:00

  • Use of hCG stimulation test in women immunized with beta-hCG vaccine.

    abstract：:Eleven normally menstruating women, who had earlier been immunized with NII beta-hCG vaccine but had no detectable anti-hCG antibody titres, were selected as controls for the hCG challenge test using 1000/2000 I.U. The test was repeated in five of them after a booster immunization, which raised antibody titres to 18-4...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0010-7824(91)90035-e

    authors： Shahani SM,Patel KL

    更新日期：1991-10-01 00:00:00

  • Comparative multicentre trial of three IUDs inserted immediately following delivery of the placenta.

    abstract：:A multinational comparative trial of three IUDs (Copper 7, Lippes loop size D and the Postpartum T) randomly inserted immediately following delivery of the placenta was conducted in six centres. A total of 841 women entered the study. As the predetermined termination indices for expulsions were exceeded at six months ...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0010-7824(80)90112-2

    authors：

    更新日期：1980-07-01 00:00:00

  • Therapeutic abortion in early pregnancy with antiprogestogen RU486 alone or in combination with prostaglandin analogue (gemeprost).

    abstract：:Abortion was attempted in 39 women in early pregnancy (less than 56 days amenorrhea) with the progesterone antagonist RU486 alone (150 mg per day for 4 days) or in combination with a PG analogue, 16,16-dimethyl-trans-delta 2-PGE1 (Gemeprost) in the form of a 1 mg vaginal pessary. Complete abortion was also attempted i...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0010-7824(86)90055-7

    authors： Cameron IT,Michie AF,Baird DT

    更新日期：1986-11-01 00:00:00

  • Inhibition of Chlamydia trachomatis growth in endometrial cells by copper: possible relevance for the use of the copper IUD.

    abstract：:There is agreement that the relative risk of developing pelvic inflammatory disease (PID) increases among women who use the intrauterine contraceptive device (IUD). The role of Chlamydia in causing PID among IUD users is not clear. The present study demonstrates that Chlamydia trachomatis growth can be inhibited in cu...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(89)90041-3

    authors： Kleinman D,Sarov I,Insler V

    更新日期：1989-06-01 00:00:00

  • Evaluation of sulprostone for second trimester abortions and its effects on liver and kidney function.

    abstract：:Sulprostone was given intramuscularly in two dose schedules of 0.5 mg at 4 hourly intervals for 8 doses and 1.0 mg at 8-hour intervals for 4 doses to 56 women in the 12th-20th week of gestation coming for termination of pregnancy. Forty-nine of them aborted within the 30-hour observation period, giving a success rate ...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0010-7824(82)90028-2

    authors： Ranjan V,Hingorani V,Kinra G,Agarwal N,Pande Y

    更新日期：1982-02-01 00:00:00

  • Effect of a combination of ethinylestradiol 30 microg and drospirenone 3 mg on tolerance, cycle control, general well-being and fluid-related symptoms in women with premenstrual disorders requesting contraception.

    abstract：PURPOSE:Positive effects on premenstrual symptoms have been observed with low-dose oral contraceptives. Drospirenone is a synthetic progestogen with antiandrogenic and antimineralocorticoid effects. This open-label, multicenter study evaluated the effects of a combination of ethinylestradiol 30 microg and drospirenone ...

    journal_title：Contraception

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.contraception.2005.10.016

    authors： Borges LE,Andrade RP,Aldrighi JM,Guazelli C,Yazlle ME,Isaia CF,Petracco A,Peixoto FC,Camargos AF

    更新日期：2006-12-01 00:00:00

  • Acceptability of Norplant implants for fertility regulation in Singapore.

    abstract：:The continuation rate at the end of this five-year clinical study was 60% with no accidental pregnancy occurring throughout the five years. The post-removal conception rate in women desiring pregnancy was 92% at the end of two years. The majority of acceptors described the overall experience with the implants as favou...

    journal_title：Contraception

    pub_type： 杂志文章

    doi：10.1016/0010-7824(92)90139-k

    authors： Singh K,Viegas OA,Fong YF,Ratnam SS

    更新日期：1992-01-01 00:00:00