Relationship of intraamniotic digoxin to fetal demise.

Abstract:

BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasonic fetal cardiac assessments 1, 2, 4 and 20 to 24 h after intraamniotic injection of 1.5 mg digoxin. RESULTS:Fetal cardiac activity was absent in 21/21 women assessed at least 20 h after injection. One woman had agonal (40 bpm) fetal cardiac activity at 14 h. Most women had fetal cardiac activity 4 h after injection. Signs of toxicity were not seen. CONCLUSION:Intraamniotic injection of digoxin 1.5 mg is effective at causing fetal demise by 20 to 24 h. However, for most women, fetal demise is not obtained within 4 h.

journal_name

Contraception

journal_title

Contraception

authors

Borgatta L,Betstadt SJ,Reed A,Feng KT

doi

10.1016/j.contraception.2009.12.001

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

328-30

issue

4

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(09)00519-8

journal_volume

81

pub_type

临床试验,杂志文章
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    pub_type: 临床试验,杂志文章,随机对照试验

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