Abstract:
BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasonic fetal cardiac assessments 1, 2, 4 and 20 to 24 h after intraamniotic injection of 1.5 mg digoxin. RESULTS:Fetal cardiac activity was absent in 21/21 women assessed at least 20 h after injection. One woman had agonal (40 bpm) fetal cardiac activity at 14 h. Most women had fetal cardiac activity 4 h after injection. Signs of toxicity were not seen. CONCLUSION:Intraamniotic injection of digoxin 1.5 mg is effective at causing fetal demise by 20 to 24 h. However, for most women, fetal demise is not obtained within 4 h.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Borgatta L,Betstadt SJ,Reed A,Feng KTdoi
10.1016/j.contraception.2009.12.001subject
Has Abstractpub_date
2010-04-01 00:00:00pages
328-30issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(09)00519-8journal_volume
81pub_type
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