Abstract：
:The ability of 40 mg of milled suspension of a new long-acting androgen ester (20 Aet-1) to restore and maintain accessory gland function was compared with that of testosterone enanthate (TE) in castrated adult rhesus monkeys. Castration did not abolish the ejaculatory response since only two animals did not void semen in the postcastration period. A single intramuscular injection of 40 mg of these compounds stimulated accessory gland function at levels lower than in the pretreatment period. 20 Aet-1-induced stimulation of prostatic acid phosphatase activity never exceeded control levels unlike that induced by testosterone enanthate which caused hyperstimulation on day 21 of drug treatment. In terms of support of accessory gland function, 20 Aet-1 would appear to offer hope of being a successful androgen for supplementation therapy in male animals.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Rajalakshmi M,Ramakrishnan PR,Kaur J,Sharma DN,Pruthi JSdoi
10.1016/0010-7824(91)90129-4subject
Has Abstractpub_date
1991-01-01 00:00:00pages
83-90issue
1eissn
0010-7824issn
1879-0518pii
0010-7824(91)90129-4journal_volume
43pub_type
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