Abstract：
BACKGROUND:In levonorgestrel intrauterine system (LNG-IUS) users, the prevention of sperm penetration through cervical mucus has not been demonstrated. STUDY DESIGN:Subjects were enrolled in an investigator-blinded study to compare quality and sperm penetrability of mid-cycle cervical mucus between LNG-IUS users and hormone-free controls. Cervical mucus was microscopically examined using World Health Organization (WHO) cervical mucus analysis (CMA). CMA score ≥10 of 15 points indicated cervical mucus favoring sperm penetration. Mucus was incubated with sperm using the WHO simplified slide test (SST) and Kremer sperm cervical mucus penetration test (SCMPT). RESULTS:Data from 14 LNG-IUS users and 16 controls showed 14% of LNG-IUS users had CMA score ≥10% vs. 69% of controls (p=.004). SST showed no sperm penetration for LNG-IUS users, significantly less than controls (0% vs. 64.3%, p<.001). SCMPT demonstrated no sperm mucus penetration for LNG-IUS users at 2 and 6 h (0% vs. 85% in controls with 2-h score ≥6, p<.001; 6 h 0% vs. 79% in controls, p<.001). CONCLUSIONS:Mid-cycle cervical mucus of LNG-IUS users is poor quality and prevents endocervical sperm transport in vitro.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Lewis RA,Taylor D,Natavio MF,Melamed A,Felix J,Mishell D Jrdoi
10.1016/j.contraception.2010.06.006subject
Has Abstractpub_date
2010-12-01 00:00:00pages
491-6issue
6eissn
0010-7824issn
1879-0518pii
S0010-7824(10)00359-8journal_volume
82pub_type
临床试验,杂志文章相关文献
CONTRACEPTION文献大全abstract：:We analyzed data from 4,905 women aged 20-39 and 14,803 aged 40-49 who attended a health survey in Norway 1985-88, to study cardiovascular risk factors in users of oral contraceptives, all types and specifically by formulation. In age group 20-39, users of low-dose estrogen/ progestin regimens were younger, had lower ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(96)00082-0
更新日期：1996-06-01 00:00:00
abstract：:A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using the levonorgestrel subdermal implants NORPLANT for contraceptive purposes. At the end of 1 year of use, results from this on-going study indicate that these subjects may have an increased predisposition to thrombosis as e...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(88)90103-5
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVE:Our objective was to compare continuation and complication rates of subdermal etonogestrel implants and intrauterine devices (IUDs) using Medicaid insurance claims. STUDY DESIGN:We performed a retrospective cohort study using insurance claims data for 15- to 44-year-old subjects receiving implants or IUDs fr...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.04.012
更新日期：2018-04-24 00:00:00
abstract：:Methotrexate (50 mg/m2 intramuscularly and 50 mg orally) followed by vaginal misoprostol have proven to be > 90% effective at causing abortion in women at less than 49 days' gestation. Although the effectiveness of the oral dose (which has a lower serum bioavailability) demonstrates that a methotrexate dose of 50 mg/m...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(97)00173-x
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Barriers to intrauterine device (IUD) use in nulliparous women include fear of pain with insertion and provider perception of difficulty with insertion. The goal of this study was to evaluate whether misoprostol prior to IUD insertion in nulliparous women eased insertion and decreased pain. STUDY DESIGN:Thi...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2013.07.011
更新日期：2013-12-01 00:00:00
abstract：:The aim of this study was to compare contraceptive reliability, cycle control, and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol (EE2) and 75 micrograms gestodene (GSD), with a reference preparation containing a similar dose of gestodene but in combination with 30 micrograms ethinylestra...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0010-7824(97)00025-5
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:Ulispristal acetate (UPA) is a selective progesterone receptor modulator widely used for emergency contraception (EC). The described main mechanism of action is by inhibiting or delaying ovulation; however, the postovulatory effects of the drug are still on debate. Therefore, the aim of this study was to dete...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.02.019
更新日期：2017-06-01 00:00:00
abstract：:Lonidamine (LND) [1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid] is a well-known antispermatogenic drug. The aim of this study was to identify its possible long-term sequelae on the reproductive system of mice as compared with rats, where most data have been obtained until now. Sexually mature CD1 male mice wer...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2005.05.019
更新日期：2005-10-01 00:00:00
abstract：:The metabolism of isotopically labeled ethinyl estradiol (EE) and mestranol (ME) was studied in 3 baboons before and after the simultaneous injection of a norethindrone-mestranol contraceptive formulation. 6 days after the administration of tritiated-EE and carbon-14-ME, the mean urinary excretion of labeled-EE was 3...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(77)90116-0
更新日期：1977-03-01 00:00:00
abstract：:A study was performed to evaluate the impact of knowledge of HIV infection (diagnosis) on contraception information and choices for HIV infected women. A questionnaire was given to 140 HIV infected women. Most of the studied population included young women with a low educational level. A significant increase in the kn...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00332-3
更新日期：2002-08-01 00:00:00
abstract：:In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(80)80001-1
更新日期：1980-09-01 00:00:00
abstract：:A small survey to assess the perception and experience of current family planning users and their husbands was carried out in a university family planning clinic. Women routinely visiting the clinic were asked to complete a short Screening Form. Fifty-six women responded to the questionnaire concerning their attitude ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(91)90118-y
更新日期：1991-08-01 00:00:00
abstract：:The effect of alpha-chlorohydrin (3-chloropropan-1,2-diol) on the metabolism of D-[U-14C]-fructose and L-[U-14C]-lactate by washed boar sperm has been investigated. Whereas alpha-chlorohydrin at concentrations as low as 0.1 mM inhibited the metabolism of fructose and led to an increase in the utilization of endogenous...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90103-1
更新日期：1980-11-01 00:00:00
abstract：:This study examined the effect of epostane, a new antifertility drug, on normal and hCG-stimulated progesterone production during the luteal phase of the menstrual cycle in rhesus monkeys. When administered once each day for five days, epostane inhibited normal luteal phase progesterone levels in a dose-related fashio...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(85)90083-6
更新日期：1985-05-01 00:00:00
abstract：:The objectives of the study were to assess the ability of the Femcap, a new vaginal contraceptive device made of silicone and designed to fit snugly around the cervix to prevent the penetration of sperm into midcycle cervical mucus when used with and without spermicide; and to compare it with the standard contraceptiv...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(97)00098-x
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:Our objective was to measure the sensitivity and specificity of a six-item "pregnancy checklist" at excluding early- or luteal-phase pregnancy among women with a negative urine pregnancy test who were initiating contraception. STUDY DESIGN:This was a secondary analysis of the Contraceptive CHOICE Project, a ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.08.002
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:This study was conducted to determine the effects of the monophasic oral contraceptive (OC) containing 30 mcg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) on the nasal respiratory epithelium in premenopausal women. STUDY DESIGN:Fifty premenopausal women participated in the prospective study. Baseline ...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/j.contraception.2007.12.010
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:Women who have abortions are at high risk of contraception discontinuation and subsequent unintended pregnancy. The objective of this analysis was to identify factors associated with choice of highly effective, long-acting, progestin-only contraceptive methods after abortion. STUDY DESIGN:Women presenting fo...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.06.013
更新日期：2015-12-01 00:00:00
abstract：:There is concern that the breast-fed infant whose mother is receiving intra-muscular progestogens for contraception will be exposed to significant quantities of the steroid. Norethisterone levels in maternal serum and milk were studied throughout an injection interval after intramuscular administration of 200mg noreth...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(83)90073-2
更新日期：1983-11-01 00:00:00
abstract：:A structured literature review was undertaken to determine, in the context of early medical abortion, the proportion of women who require analgesia, the predictors of analgesia requirement and the most appropriate analgesia regimen. Studies from different centers show wide variations in analgesia use, but, overall, ar...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2006.03.002
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Rural-to-urban migrant women in Shanghai have poor reproductive health; the incidence of postpartum unintended pregnancy and contraceptive practices has not been adequately studied in this population. STUDY DESIGN:This retrospective study examined the incidence of postpartum unintended pregnancy and associa...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2012.05.007
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:We sought to assess fulfillment of sterilization requests while accounting for the complex interplay between insurance, clinical and social factors in a contemporary context that included both inpatient and outpatient postpartum sterilization procedures. STUDY DESIGN:This is a retrospective single-center coh...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.02.012
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the need for and outcome of self-administered medical abortion with mifepristone and misoprostol in Brazil, provided through Women on Web, a global telemedicine abortion service. STUDY DESIGN:A retrospective case review of women from Brazil who contacted Women on Web in 2011. Information from the...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.11.005
更新日期：2014-02-01 00:00:00
abstract：:One-hundred-thirty of 178 women who received Norplant-2 implants were followed prospectively for 4 years. Menstrual disorders were the most common reason for discontinuation. Only one patient conceived, for a failure rate of 0.6%. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(01)00265-7
更新日期：2001-11-01 00:00:00
abstract：:A mixture of two partially triterpenoid saponins (Tg), isolated from Acacia auriculiformis was tested for sperm immobilizing activity by using in vitro system. The lowest concentration (ED) required for an obvious immobilization of human sperm by using a modified Sander-Cramer test was found to be 0.35 mg/ml in physio...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(91)90137-5
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVE:This study estimates how making oral contraceptive pills (OCPs) available without a prescription may affect contraceptive use, unintended pregnancies and associated contraceptive and pregnancy costs among low-income women. STUDY DESIGN:Based on published figures, we estimate two scenarios [low over-the-count...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.01.010
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVES:As obesity may affect the efficacy of some contraceptives, we examined weight, body mass index (BMI) and prevalence of obesity among female contraceptive clients at 231 U.S. health centers. A secondary aim was to analyze differences in contraceptive method use by obesity status. STUDY DESIGN:Cross-sectional...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.02.006
更新日期：2015-06-01 00:00:00
abstract：:The objectives of this study were to define the "normal" position of the T-shaped intrauterine device (IUD) in the endometrial cavity, using transvaginal ultrasound, and to compare the IUD's position in women with and without complaints of bleeding and/or pain. Vaginal ultrasound was carried out in women who had used ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(97)00072-3
更新日期：1997-07-01 00:00:00
abstract：:Users of subdermal contraceptive implants report long duration of use, convenience, and high efficacy as liked features and bleeding irregularities, weight loss/gain, and headaches as disliked effects of these methods. Satisfied users tend to be women who do not experience side effects or women who value positive feat...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/s0010-7824(01)00281-5
更新日期：2002-01-01 00:00:00
abstract：:In pharmacological test models providing repeated daily administrations of steroid hormones, differing time courses of the drug level depending upon the pharmacokinetics can be observed often. The present study should make a contribution to the question whether the time course of the drug level can have an influence o...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(84)90068-4
更新日期：1984-04-01 00:00:00
