Abstract：
:Lonidamine (LND) [1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid] is a well-known antispermatogenic drug. The aim of this study was to identify its possible long-term sequelae on the reproductive system of mice as compared with rats, where most data have been obtained until now. Sexually mature CD1 male mice were administered a single dose of LND (200 mg/kg bw by gavage) and killed 24 and 48 h, 6 days and 2, 4 and 8 weeks after the treatment. Testes were collected, weighed and (1) fixed in Bouin's solution for histological analysis or (2) reduced to monocellular suspensions and ethanol fixed to undergo flow cytometry (FCM) DNA content analysis. No effect on body weight and/or food consumption was observed in the treated group in comparison with the control group. Testicular weight was significantly reduced 24 h after the treatment. Reduced seminiferous epithelium with a progressive lack of intercellular cohesion and marked depletion of spermatids, infiltration of granulocytes, desquamation into the tubular lumen and increased intertubular spaces were present by 24 h after the treatment and persisted to a marked degree at 48 h, 6 days and 2 and 4 weeks up to a marked degeneration of tubular structures with absence of spermatogenesis. The same effects, albeit with a moderate severity, were still present 8 weeks after the treatment. As also detected by FCM, primary spermatocytes appeared to be the main cellular target. Sertoli and Leydig cells were remarkably spared. The histological findings are consistent with those previously observed in rats and point out that testicular damage may persist for several weeks after a single-dose administration. Findings are discussed in comparison with testicular toxicity elicited by other xenobiotics.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Maranghi F,Mantovani A,Macrì C,Romeo A,Eleuteri P,Leter G,Rescia M,Spanò M,Saso Ldoi
10.1016/j.contraception.2005.05.019subject
Has Abstractpub_date
2005-10-01 00:00:00pages
268-72issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(05)00216-7journal_volume
72pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:Mature epididymal boar spermatozoa converted fructose, glycerol and glycerol-3-phosphate to carbon dioxide, but in the presence of 0.5 mM 3-bromopyruvate, these oxidations were inhibited while that of lactate was unaffected. Inhibition of the oxidation of these substrates results in a decrease in the content of ATP an...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(95)00217-x
更新日期：1995-11-01 00:00:00
abstract：BACKGROUND:Fear of adverse effects on subsequent fertility following reversible contraceptive use is an important concern for some women. STUDY DESIGN:We undertook a comprehensive and objective review of the literature for prospective studies reporting pregnancy rates in women following contraceptive cessation. One-ye...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2011.04.002
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Patient characteristics associated with adherence to dual-method contraceptive use are not known. STUDY DESIGN:Project PROTECT was a 24-month-long randomized trial designed to promote the use of dual methods of contraception using an individualized computer-based intervention or enhanced standard care couns...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2011.01.023
更新日期：2011-09-01 00:00:00
abstract：:This paper presents a secondary analysis of 3419 Norplant users from 11 countries throughout Asia, Africa and Latin America. The main objective was to identify the menstrual problems associated with a high risk of early discontinuation of Norplant use. Eligible participants were divided into two groups: those who cont...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(03)00040-4
更新日期：2003-05-01 00:00:00
abstract：:The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of spe...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(03)00076-3
更新日期：2003-07-01 00:00:00
abstract：:An injectable method of obtaining vas deferens occlusion is presented. The agent used is styrene maleic anhydride (SMA) with dimethyl sulphoxide as the solvent. The special feature of the approach is that after a period of time, spermatozoa passage is spontaneously reestablished. By varying the dose of SMA administere...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(90)90073-5
更新日期：1990-03-01 00:00:00
abstract：:Fifteen healthy subjects used a contraceptive device, namely an intravaginal ring releasing 20 micrograms levonorgestrel daily, for 12 weeks. High, low and very low density fractions of cholesterol, triglyceride and phospholipids were measured, together with oral glucose tolerance before and after 12 weeks of use. The...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(84)90078-7
更新日期：1984-07-01 00:00:00
abstract：:The incidence of Candida albicans (C.A.) infection of the vagina was evaluated in vaginal discharges obtained from 85 subjects using a large battery of culture media and confirmatory tests. Twenty women using DMPA 150 mg i.m. contraceptive injections for more than one year (long-term users) were compared with forty 2n...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(79)90082-9
更新日期：1979-08-01 00:00:00
abstract：BACKGROUND:The use of progestogen-only contraceptives by breastfeeding women raises theoretical concerns regarding possible adverse effects on breastfeeding success, and infant health or growth. This review was conducted to determine from the literature whether use of progestogen-only contraceptives by breastfeeding wo...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2010.02.002
更新日期：2010-07-01 00:00:00
abstract：:The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women. Group 1 consisted of women not currently using oral contraceptives; Group 2 consisted of women switching to Femoden...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(87)90069-2
更新日期：1987-04-01 00:00:00
abstract：:The effect of alpha-chlorohydrin (3-chloropropan-1,2-diol) on the metabolism of D-[U-14C]-fructose and L-[U-14C]-lactate by washed boar sperm has been investigated. Whereas alpha-chlorohydrin at concentrations as low as 0.1 mM inhibited the metabolism of fructose and led to an increase in the utilization of endogenous...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90103-1
更新日期：1980-11-01 00:00:00
abstract：BACKGROUND:The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. STUDY DESIGN:This study evaluated in v...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.08.014
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To compare time from misoprostol initiation to fetal expulsion for mifepristone-misoprostol versus misoprostol-alone regimens of medication abortion performed at ≥24 weeks' gestation. STUDY DESIGN:We conducted a retrospective study of medication abortion performed at ≥24 weeks' gestation between May 2016 and...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.05.001
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:We aimed to determine the efficacy of fennel and low-dose combined oral contraceptive (LD-COC) on inducing menstrual bleeding and method continuation in women using depot medroxyprogesterone acetate (DMPA) who had no menstrual bleeding within the previous 45 to 140 days. STUDY DESIGN:In this double-blind do...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2014.05.001
更新日期：2014-10-01 00:00:00
abstract：:The ability of the condom wall to maintain its integrity throughout sexual intercourse is critical to its role in halting the spread of major sexually transmissible pathogens including the human immunodeficiency virus. There are three principal in vitro performance tests applied to condoms: a test for freedom from hol...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(91)90045-h
更新日期：1991-02-01 00:00:00
abstract：:A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. Restoration of fertility was characterized by a reduction of the litter size resulting from the first inpregnation post-treatment. There was no evidence of tissue pathogenesis 6-12 months after treatment. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90061-x
更新日期：1980-08-01 00:00:00
abstract：:We evaluated the efficacy and side effects of immediate postcoital administration of levonorgestrel 0.75 mg used repeatedly for contraception. A total of 295 healthy women with infrequent coitus were enrolled at 6 study sites. Each woman took levonorgestrel 0.75 mg by mouth immediately after intercourse during 6 month...
journal_title：Contraception
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:In a prospective, randomised dose-finding study involving 60 women scheduled for termination of 1st trimester pregnancy, 25 micrograms, 50 micrograms or 100 micrograms of a sulprostone gel with a constant injection volume of 2.5 ml were applied intracervically 6-8 hours before curettage. The gelatinising agent was Plu...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(85)90091-5
更新日期：1985-03-01 00:00:00
abstract：OBJECTIVE:Pharmacokinetics of norethindrone in combination oral contraceptive regimen are well described among HIV+ women treated with ritonavir-boosted protease inhibitor therapies; however, such characterization is lacking in women using progestin-only contraception. Our objective is to characterize pharmacokinetics ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.08.009
更新日期：2015-01-01 00:00:00
abstract：:In a case-control study of 1647 breast cancer cases and 1501 population controls under 45 years of age, potential modifying effects of other risk factors on the relationship of oral contraceptives to breast cancer were examined. Among the total series of study subjects, the relationship of extended pill usage was grea...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(97)00012-7
更新日期：1997-04-01 00:00:00
abstract：:Fructose levels and fructolysis index in human semen were analysed to assess a correlation, if any, between the levels of this glycolysable sugar and sperm concentration. Semen was collected from normospermic men and men with azoospermia or oligospermia. Seminal fructose levels were elevated in men with obstructive az...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(89)90062-0
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:Previous survey research indicates that women and men experience reduced sexual pleasure when using condoms, especially compared to nonbarrier family planning methods. This study seeks to explore those experiences of reduced pleasure in-depth and how they affect contraceptive method decisions and use. STUDY ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.11.012
更新日期：2014-04-01 00:00:00
abstract：:There is a global need for an ideal method of male contraception. However, the development of male contraceptives has not been well successful. Research on sperm-specific ion channels, especially the recent advance obtained from electrophysiological studies, has emphasized the conception that those channels are target...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2013.06.002
更新日期：2013-10-01 00:00:00
abstract：:The effects of phenytoin treatment on plasma concentrations of norethisterone (NET) was studied in 7 healthy female rhesus monkeys. Before phenytoin treatment was started each monkey received an oral dose of 0.5 mg NET and 2 weeks later the same dose was given intravenously. On both occasions, plasma concentrations of...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(83)80021-3
更新日期：1983-04-01 00:00:00
abstract：:Open-ended vasectomy was performed on one-hundred men. Sixty-three of them showed up for follow-up six months later. Spontaneous recanalisation had occurred in two. Sperm granuloma without orchialgia was found in 14 out of 59 men (23.9%). Twenty-one out of the 63 thought their sex life had improved, while 40 thought i...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(86)90040-5
更新日期：1986-06-01 00:00:00
abstract：:Gossypol has been shown to inhibit steroidogenesis in leydig cells. This study examined the mechanism of this action by investigating the effect of gossypol on leydig cell hCG receptor binding, adenylate cyclase activity and cyclic AMP production in leydig cells. Gossypol had no effect on hCG binding to cell membranes...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(86)80019-1
更新日期：1986-12-01 00:00:00
abstract：:The purpose of the study was to evaluate semen quality in young Chinese men and to establish reference values. Normal healthy young men from seven geographical areas were enrolled. The study showed that the mean sperm volume was 2.61 mL, and mean percent of sperm with forward progression was 59.89, while median of sem...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00281-0
更新日期：2002-05-01 00:00:00
abstract：:Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg Mi...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(88)90102-3
更新日期：1988-09-01 00:00:00
abstract：:One-hundred-thirty of 178 women who received Norplant-2 implants were followed prospectively for 4 years. Menstrual disorders were the most common reason for discontinuation. Only one patient conceived, for a failure rate of 0.6%. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(01)00265-7
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVES:The aim of this survey was to understand US women's contraception journey from her first prescribed method to her current one including reasons for choosing and stopping/switching methods, healthcare provider relationships, and bleeding preferences. STUDY DESIGN:We administered a nationally-representative, ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.09.010
更新日期：2018-03-01 00:00:00
