Abstract:
OBJECTIVES:We aimed to determine the efficacy of fennel and low-dose combined oral contraceptive (LD-COC) on inducing menstrual bleeding and method continuation in women using depot medroxyprogesterone acetate (DMPA) who had no menstrual bleeding within the previous 45 to 140 days. STUDY DESIGN:In this double-blind double-dummy trial, 78 married women referred to public health centers in Hamadan, Iran, who complained of menstrual cessation induced by DMPA were randomly assigned into fennel, LD-COC or placebo groups with an allocation ratio of 1:1:1. All participants received two fennel or placebo capsules and one placebo or LD-COC pill daily for 21 days. We evaluated menstrual bleeding using the Higham pictorial chart within 40 days following initiating intervention. Data were analyzed using chi-square or analysis of variance. RESULTS:There was no loss to follow-up. Significantly more women in the fennel (73%) and LD-COC (81%) groups experienced menstrual bleeding compared to the placebo (19%) group [relative risk (RR) 3.1, 95% confidence interval (CI) 1.6 to 6.2; RR 4.2, 95% CI 1.9 to 9.4, respectively]. Mean amount of menstrual bleeding among those who experienced menstruation was significantly higher in the fennel group (21 cc) than both the LD-COC (14 cc) and placebo (12 cc) groups. Also, women using fennel (73%) and LD-COC (65%) were significantly more likely than those using placebo (31%) to have subsequent DMPA injection [RR 2.5 (95% CI 1.3 to 4.9) and RR 2.0 (95% CI 1.1 to 3.7), respectively]. CONCLUSIONS:Fennel and LD-COC can resolve DMPA-induced amenorrhea and increase continuation rate of this contraceptive method.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Mohebbi-Kian E,Mohammad-Alizadeh-Charandabi S,Bekhradi Rdoi
10.1016/j.contraception.2014.05.001subject
Has Abstractpub_date
2014-10-01 00:00:00pages
440-6issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(14)00244-3journal_volume
90pub_type
杂志文章,随机对照试验相关文献
CONTRACEPTION文献大全abstract:OBJECTIVE:To assess the safety profile of the low-dose levonorgestrel intrauterine system (LNG-IUS) total content 13.5mg (average approximate release rate 8μg/24h over the first year; LNG-IUS 8; Jaydess®) in adolescents. STUDY DESIGN:In a Phase III study in 36 European centers, 304 healthy nulliparous or parous postme...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/j.contraception.2016.02.004
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Concomitant use of antiretroviral (ARV) and hormonal contraceptives may change the metabolism of each and the resulting safety profiles. We evaluated the safety and tolerability of depot medroxyprogesterone acetate (DMPA) among women on ARV. STUDY DESIGN:HIV-infected women on selected ARV regimens or no ARV...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2007.10.002
更新日期:2008-02-01 00:00:00
abstract::A questionnaire study was carried out to investigate the needs of women undergoing a medical abortion induced by mifepristone in combination with either gemeprost pessaries or oral misoprostol. One-hundred-and-eighty women undergoing medical abortion of pregnancy of up to 63 days amenorrhoea were randomised to treatme...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(92)90147-l
更新日期:1992-11-01 00:00:00
abstract::There is a global need for an ideal method of male contraception. However, the development of male contraceptives has not been well successful. Research on sperm-specific ion channels, especially the recent advance obtained from electrophysiological studies, has emphasized the conception that those channels are target...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2013.06.002
更新日期:2013-10-01 00:00:00
abstract::Emergency contraception promises to reduce Mexico's high unwanted pregnancy and unsafe abortion rates. Because oral contraceptives are sold over-the-counter, several emergency contraceptive regimens are already potentially available to those women who know about the method. Soon, specially packaged emergency contracep...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(99)00088-8
更新日期:1999-10-01 00:00:00
abstract::The effects of cyproterone acetate (CPA), administered orally in dos es of either 10 or 20 mg/day for 26 weeks, were studied in 15 healthy male volunteers. During treatment, there was a decrease in sperm density and in normal-shaped sperm and an increase in pathological and immature forms, an increase in dead spermat...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(76)90081-0
更新日期:1976-08-01 00:00:00
abstract::The temporal effects of oral administration of cyproterone acetate (CPA), a progestational androgen receptor blocker, were studied on the fertility of adult male rat sires, at a dose of 20 mg kg-1 day-1 after 15 days of gavage. The treatment reduced the fertility and weights of accessory sex glands, without altering t...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.11.003
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Little research has investigated women's interest in and factors associated with viewing their ultrasound image in abortion care. STUDY DESIGN:Using medical records for all abortion care visits in 2011 (n = 15,575) at an urban abortion provider, we determined the proportion of women who chose to view by soc...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/j.contraception.2013.07.006
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:This analysis was undertaken to compare the effect of the different dosages and formulations of spermicides containing nonoxynol-9 (N-9) on cervical cytology. STUDY DESIGN:A randomized trial was conducted at 14 sites in the United States to evaluate the effectiveness and safety of five spermicides containin...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2007.11.015
更新日期:2008-03-01 00:00:00
abstract::A multicentre randomized clinical trial of the TCu220C, Lippes Loop D and Copper 7 was undertaken in nine WHO Collaborating centres for Clinical Research in Human Reproduction. A total of 984, 992 and 994 devices, respectively, were inserted between 1976 and 1978. The subjects were followed for two years. At this time...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(82)90167-6
更新日期:1982-07-01 00:00:00
abstract:PURPOSE:This prospective study aimed to assess the possible effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and fasting blood glucose levels over a period of 1 year. METHODS:Forty-eight premenopausal women, attending our gynecology clinic with the complaint of menorrhagia, were en...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.12.005
更新日期:2006-05-01 00:00:00
abstract::A multicentric trial in 9 Spanish Clinics of Family Planning was conducted to evaluate the effectiveness of a vaginal contraceptive Ovule (suppository), containing 18.9 mg of benzalkonium chloride. Gynaecological and cytobacteriological examinations were made to evaluate any possible side-effect. Six-hundred-fifty-thr...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(86)90088-0
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the presence of ovarian cysts in women using a new low-dose levonorgestrel-releasing intrauterine contraceptive system (LNG-IUS 13.5mg [total content]). STUDY DESIGN:A Phase 3 study assessed LNG-IUS 13.5mg use in healthy women with regular menstrual cycles who requested co...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2015.01.021
更新日期:2015-05-01 00:00:00
abstract::The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(85)90108-8
更新日期:1985-08-01 00:00:00
abstract::The influence of copper ions on myometrial activity was tested in nonpregnant rabbits in vitro and in vivo, and nonpregnant women in vivo. In an organ bath, CuCl2 in concentrations of 3 micro M and higher caused a dose-dependent increase in the contractile activity of isolated rabbit myometrium. In rabbits in vivo, in...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90092-5
更新日期:1981-08-01 00:00:00
abstract::Numerous non-comparative clinical trials of the Dalkon Shield appear to provide ample evidence that the Dalkon Shield was an effective IUD; they seem to yield little evidence that it was a dangerous device, nor markedly different from its contemporaries. Equating the performance of the Dalkon Shield IUD to that of the...
journal_title:Contraception
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1016/0010-7824(93)90060-k
更新日期:1993-07-01 00:00:00
abstract::Conventional oral contraceptive (OC) starting instructions require waiting until menses to begin the OC. The conventional approach requires detailed patient education about when to begin and also may require the use of less effective or less acceptable interim contraceptive protection until menses. At our urban family...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00351-7
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:There has been some study of women's emotional and psychological well-being after an abortion but no research into women's expectations, at the time of seeking an abortion, of how they will cope after the abortion. STUDY DESIGN:We abstracted counseling needs assessment forms of 5109 women who sought an abor...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2011.11.002
更新日期:2012-07-01 00:00:00
abstract::A variety of epidemiological approaches have been used to assess the safety of steroid contraceptives. Each study design has its own strengths and weaknesses, especially with respect to susceptibility to bias and confounding. Randomized controlled trials provide the strongest evidence of a cause and effect relationshi...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/s0010-7824(98)00013-4
更新日期:1998-03-01 00:00:00
abstract::The metabolism of isotopically labeled ethinyl estradiol (EE) and mestranol (ME) was studied in 3 baboons before and after the simultaneous injection of a norethindrone-mestranol contraceptive formulation. 6 days after the administration of tritiated-EE and carbon-14-ME, the mean urinary excretion of labeled-EE was 3...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(77)90116-0
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:Although widely used, the mechanisms of action of the levonorgestrel emergency contraceptive pill (LNG ECP) are still unclear. There are increasing data to indicate that LNG is particularly effective as an ECP by interrupting follicular development and ovulation. An important outstanding question is whether ...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.contraception.2006.08.015
更新日期:2007-02-01 00:00:00
abstract::The effect of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro-5-triazole (5,1a)-isoquinoline, a non-hormonal post-implantational anti-fertility drug, on tissue weights, nucleic acids and total protein concentrations in the testes, ventral prostate and seminal vesicles were evaluated in immature and sexually mature rats, while ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(87)90008-4
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:To understand teen birth trends in Georgia by racial and geographic factors. STUDY DESIGN:We analyzed overall birth and repeat teen birth rates by race, urban/rural status and adequacy of obstetric care from 2008 to 2016 using vital records from all Georgia counties. RESULTS:Overall birth rates among teens ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.11.007
更新日期:2019-03-01 00:00:00
abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90107-i
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Ethinyl estradiol (EE) and progestins have the ability to alter endothelial function. The type of progestin and the ratio of EE to progestin used in oral contraceptive pills (OCPs) may determine how they affect the arterial vasculature. STUDY DESIGN:In this study, we investigated endothelial function across...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2008.07.025
更新日期:2009-01-01 00:00:00
abstract::Mechanisms for the therapeutic effect of oral contraceptives in dysmenorrhea were studied by recording intrauterine pressure on the first day of menstrual bleeding in women with moderate to severe symptoms and after three weeks of oral contraceptive therapy (150 micrograms levonorgestrel + 30 micrograms ethinyl estrad...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90026-7
更新日期:1989-07-01 00:00:00
abstract::A long-term follow-up study compared development and health of 128 breast-fed children whose mothers had received depot-medroxyprogesterone acetate (depot-MPA) while lactating and 142 control children whose mothers had used mechanical contraceptives or no contraceptives or had undergone sterilization. The children, wh...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(84)90002-7
更新日期:1984-12-01 00:00:00
abstract::Medically induced abortion using a new regimen of oral mifepristone 600 mg and vaginal misoprostol 800 micrograms (PGE1 analogue) was carried out in 100 women. Abortion occurred in all patients without resort to surgery. In 99 women, the abortion occurred within 4 hours of the administration of the prostaglandin. Sixt...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(94)90085-x
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:In the United States, the popularity of intrauterine devices (IUDs) is low despite many positive attributes such as high effectiveness and ease of use. The requirement that a clinician remove the IUD may limit US women's interest in the method. Our objective was to describe women's experience with self-remov...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.01.025
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:We examine the lifetime and past-year prevalence and circumstances of unprotected intercourse among members of the Society of Family Planning (SFP), a professional reproductive health organization in the United States. STUDY DESIGN:We invited the membership of SFP (n=477) via email to participate in an anon...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.04.004
更新日期:2015-07-01 00:00:00