A comparison of the effects of nonoxynol-9 and chlorhexidine on sperm motility.

Abstract:

:The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 mg/ml for chlorhexidine. The implications of these findings in relation to the comparison of the effects of drugs on sperm motility and the development of new contraceptive agents are discussed.

journal_name

Contraception

journal_title

Contraception

authors

Louis SM,Pearson RM

doi

10.1016/0010-7824(85)90108-8

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

199-205

issue

2

eissn

0010-7824

issn

1879-0518

pii

0010-7824(85)90108-8

journal_volume

32

pub_type

杂志文章
  • The effect of levonorgestrel-releasing intrauterine device on menorrhagia in women taking anticoagulant medication after cardiac valve replacement.

    abstract:BACKGROUND:This study was conducted to evaluate the effect of levonorgestrel-releasing intrauterine devices (LNG-IUDs) on menorrhagia in patients receiving anticoagulant therapy after cardiac valve replacement. STUDY DESIGN:Forty women with menorrhagia who underwent cardiac valve replacement and were taking anticoagul...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2009.02.007

    authors: Kilic S,Yuksel B,Doganay M,Bardakci H,Akinsu F,Uzunlar O,Mollamahutoglu L

    更新日期:2009-08-01 00:00:00

  • Domestic violence against women seeking induced abortion in China.

    abstract::A cross-sectional study was conducted to investigate the prevalence, type and severity of domestic violence (DV), and determine the factors related to DV among women seeking induced abortion in China. A total of 1215 women seeking induced abortion were interviewed. The results show that the prevalence of DV among part...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.02.010

    authors: Wu J,Guo S,Qu C

    更新日期:2005-08-01 00:00:00

  • Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. VI. Alteration in nuclear factors for interaction with histone gene promoter.

    abstract::This article reports the effects of gossypol at the genomic level in rat spermatogenic cells. After gossypol treatment for various times (8, 12, and 19 weeks), the spermatogonial cells were allowed to rest for 2 to 4 weeks. The function of histone H4 gene promoter (H4GP) in the repopulating pachytene spermatocytes (RP...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(95)00139-5

    authors: Teng CS,Yang NY,Chen Y

    更新日期:1995-08-01 00:00:00

  • Comparative effects of Lunelle monthly contraceptive injection (medroxyprogesterone acetate and estradiol cypionate injectable suspension) and ortho-Novum 7/7/7 oral contraceptive (norethindrone/ethinyl estradiol triphasic) on lipid profiles. Investigator

    abstract::As part of a 60-week, open-label, nonrandomized, parallel, controlled study comparing a monthly contraceptive injection containing medroxyprogesterone acetate (MPA) 25 mg and estradiol cypionate (E(2)C) 5 mg (Lunelle Monthly Contraceptive Injection) and a norethindrone 0.5, 0.75, 1.0 mg/0.035 mg ethinyl estradiol (NET...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(99)00114-6

    authors: Cromie MA,Maile MH,Wajszczuk CP

    更新日期:2000-01-01 00:00:00

  • Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill. A literature review.

    abstract::There is considerable variation in opinion about the importance of drug interactions between the combined oral contraceptive pill (COCP) and broad-spectrum antibiotics. Clinical practice varies widely, especially between doctors in Europe and those in the US. Rifampicin and griseofulvin induce hepatic enzymes and do a...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/s0010-7824(99)00009-8

    authors: Weaver K,Glasier A

    更新日期:1999-02-01 00:00:00

  • Evaluation of one-hundred open-ended vasectomies.

    abstract::Open-ended vasectomy was performed on one-hundred men. Sixty-three of them showed up for follow-up six months later. Spontaneous recanalisation had occurred in two. Sperm granuloma without orchialgia was found in 14 out of 59 men (23.9%). Twenty-one out of the 63 thought their sex life had improved, while 40 thought i...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(86)90040-5

    authors: Temmerman M,Cammu H,Devroey P,Amy JJ

    更新日期:1986-06-01 00:00:00

  • Embryo lethality of Stryphnodendron polliphyllum M. in rats.

    abstract::To study the effect of Stryphnodendron polliphyllum M. upon implantation, the seeds and empty pods of this plant were given to pregnant rats, on the 5th and 6th days of gestation. The animals were sacrificed on the 14th day of pregnancy and implantation and resorption indices were studied. The results show definite em...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(79)80045-1

    authors: Guerra MO,Araujo FC,Peters VM,Andrade AT

    更新日期:1979-10-01 00:00:00

  • A cross-over study of three oral contraceptives containing ethinyloestradiol and either desogestrel or levonorgestrel.

    abstract::A randomised cross-over trial was performed to compare the pharmacodynamic actions of three low-dose oral contraceptives (OCs): Marvelon (150 micrograms desogestrel (DSG)+ 30 micrograms ethinyloestradiol (EE)), Mercilon (150 micrograms DSG + 20 micrograms EE) and Microgynon (150 micrograms levonorgestrel (LNG) + 30 mi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(92)90103-z

    authors: Song S,Chen JK,Yang PJ,He ML,Li LM,Fan BC,Rekers H,Fotherby K

    更新日期:1992-06-01 00:00:00

  • Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.

    abstract:BACKGROUND:This study investigated the effects of adding levomefolate calcium 0.451 mg (the calcium salt of L-5-methyltetrahydrofolate; Metafolin®) to an oral contraceptive containing ethinylestradiol (EE) 20 mcg/drospirenone (drsp) 3 mg on folate levels in healthy women seeking contraception. STUDY DESIGN:In this ran...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2011.05.013

    authors: Bart S Sr,Marr J,Diefenbach K,Trummer D,Sampson-Landers C

    更新日期:2012-01-01 00:00:00

  • A comparative study of Neo Sampoon, Ortho Vaginal Tablets and Emko Vaginal Tablets in Accra, Ghana.

    abstract::Neo Sampoon is an effervescent contraceptive vaginal tablet manufactured in Japan that contains 60 mg of the spermicide menfegol. Ortho Vaginal Tablets (OVT) and Emko Vaginal Tablets (EVT), both containing 100 mg of the spermicide nonoxynol-9, were manufactured in the USA. The three products were compared in a randomi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(85)90015-0

    authors: Lamptey P,Klufio C,Smith SC,Feldblum PJ

    更新日期:1985-11-01 00:00:00

  • Menstrual patterns and progesterone circulating levels following different procedures of tubal occlusion.

    abstract::This study was undertaken to assess the effects of different tubal occlusion procedures on ovarian function. Three groups of subjects randomized to tubal occlusion by laparoscopy and Yoon ring (24 subjects), minilaparotomy and Yoon ring (19 subjects) and minilaparotomy and Pomeroy (22 subjects), and one separate contr...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(89)90003-6

    authors: Rivera R,Gaitan JR,Ruiz R,Hurley DP,Arenas M,Flores C,Hernandez AB

    更新日期:1989-08-01 00:00:00

  • Plasma lipoproteins and fatty acid composition after "minipill".

    abstract::A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(83)90038-0

    authors: Sassolas A,Lagarde M,Guichardant M,Quincy C,Dechavanne M

    更新日期:1983-10-01 00:00:00

  • Intrauterine devices and endometrial cancer. The WHO Collaborative Study of Neoplasia and Steroid Contraceptives.

    abstract::The relationship between intrauterine device (IUD) use and the development of endometrial cancer was assessed in data from seven countries that were collected between 1979 and 1988 for a multinational hospital-based case-control study. Two hundred twenty-six cases of endometrial cancer were compared with 1,529 control...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(96)00199-0

    authors: Rosenblatt KA,Thomas DB

    更新日期:1996-12-01 00:00:00

  • Developing future leaders in reproductive health through a scholarly concentration for medical students.

    abstract:OBJECTIVES:To evaluate the impact of a scholarly concentration for medical students, which aims to develop students' research, clinical and advocacy skills to promote women's reproductive health. STUDY DESIGN:Scholarly concentration programs provide opportunities to engage in scholarship beyond the traditional medical...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.07.005

    authors: Nothnagle M,Radlinski H,Magee SR,Allen RH

    更新日期:2014-11-01 00:00:00

  • Development and evaluation of matrix type transdermal patch of ethinylestradiol and medroxyprogesterone acetate for anti-implantation activity in female Wistar rats.

    abstract:BACKGROUND:Medroxyprogesterone acetate (MPA), which increases high-density lipoprotein level, has not been used as a progestin in combination with estrogen in a transdermal patch to date. The aim of the research was to develop and evaluate a matrix-type transdermal drug delivery (TDD) system of a combination of ethinyl...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.03.005

    authors: Agrawal SS,Pruthi JK

    更新日期:2011-11-01 00:00:00

  • Mode of long-term antifertility effect of intrauterine neem treatment (IUNT).

    abstract::The mode of antifertility action of intrauterine neem treatment (IUNT) was studied. The effect of IUNT on ovarian functions and uterine responsiveness to ovarian hormones was examined in adult Wistar rats. The treated animals had normal reproductive cycles as indicated by the vaginal smears; serum progesterone levels ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(95)00018-6

    authors: Kaushic C,Upadhyay S

    更新日期:1995-03-01 00:00:00

  • Effect of a combination of ethinylestradiol 30 microg and drospirenone 3 mg on tolerance, cycle control, general well-being and fluid-related symptoms in women with premenstrual disorders requesting contraception.

    abstract:PURPOSE:Positive effects on premenstrual symptoms have been observed with low-dose oral contraceptives. Drospirenone is a synthetic progestogen with antiandrogenic and antimineralocorticoid effects. This open-label, multicenter study evaluated the effects of a combination of ethinylestradiol 30 microg and drospirenone ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.contraception.2005.10.016

    authors: Borges LE,Andrade RP,Aldrighi JM,Guazelli C,Yazlle ME,Isaia CF,Petracco A,Peixoto FC,Camargos AF

    更新日期:2006-12-01 00:00:00

  • Antichlamydial activity of cervical secretion in different phases of the menstrual cycle and influence of hormonal contraceptives.

    abstract::Cervical secretion from three groups of asymptomatic women, either being oral contraceptive (OC) non-users or users (ethinylestradiol plus desogestrel or levonorgestrel), was tested for its capacity to prevent Chlamydia trachomatis, serotype I, from forming inclusions in cycloheximide-treated McCoy cells. The non-user...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(94)90044-2

    authors: Mahmoud EA,Hamad EE,Olsson SE,Mårdh PA

    更新日期:1994-03-01 00:00:00

  • Apoptosis occurs in implantation site of the rhesus monkey during early stage of pregnancy.

    abstract::The exact role of apoptosis that occurs in human placenta during the early stage of pregnancy remains unknown because of the difficulty in obtaining the intact implantation site. In this study, we used rhesus monkey as an animal model to examine apoptosis occurring in the implantation site at various stages of early p...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00241-4

    authors: Fei G,Peng W,Xin-Lei C,Zhao-Yuan H,Yi-Xun L

    更新日期:2001-09-01 00:00:00

  • Cost-effectiveness of treatments for dysfunctional uterine bleeding in women who need contraception.

    abstract:OBJECTIVE:This study aims to compare the cost-effectiveness of oral contraceptives (OCs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and surgical management in treating dysfunctional uterine bleeding (DUB) in women not desiring additional children. METHOD:A Markov model was constructed from the perspec...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2006.03.024

    authors: Blumenthal PD,Trussell J,Singh RH,Guo A,Borenstein J,Dubois RW,Liu Z

    更新日期:2006-09-01 00:00:00

  • A twelve-month comparative clinical investigation of two low-dose oral contraceptives containing 20 micrograms ethinylestradiol/75 micrograms gestodene and 30 micrograms ethinylestradiol/75 micrograms gestodene, with respect to efficacy, cycle control, an

    abstract::The aim of this study was to compare contraceptive reliability, cycle control, and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol (EE2) and 75 micrograms gestodene (GSD), with a reference preparation containing a similar dose of gestodene but in combination with 30 micrograms ethinylestra...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0010-7824(97)00025-5

    authors: Endrikat J,Müller U,Düsterberg B

    更新日期:1997-03-01 00:00:00

  • Intra-amniotic prostaglandin PGF2alpha (THAM salt) and the laminaria tent in midtrimester termination of pregnancy.

    abstract::20 patients underwent intraamniotic administration of PGF2alpha for termination of pregnancies ranging from 14-20 weeks gestation. Success was achieved in 18 patients (90%) with this method. The 2 failures were terminated vaginally with adjunctive use of intracervical laminaria and intravenous pitocin induction. 10...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(74)90049-3

    authors: Berman R,Hale RW,Reich LA,Pion RJ

    更新日期:1974-06-01 00:00:00

  • Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant.

    abstract::Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm o...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0010-7824(95)00263-4

    authors: Coutinho EM,de Souza JC,Athayde C,Barbosa IC,Alvarez F,Brache V,Gu ZP,Emuveyan EE,Adekunle AO,Devoto L,Shaaban MM,Salem HT,Affandi B,de Acosta OM,Mati J,Ladipo OA

    更新日期:1996-02-01 00:00:00

  • Studies on mechanism(s) of antifertility action of gossypol in rat and hamster.

    abstract::This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90066-8

    authors: Srivastava A,Gupta G,Setty BS

    更新日期:1989-03-01 00:00:00

  • Ethinyl estradiol and levonorgestrel pharmacokinetics with a low-dose transdermal contraceptive delivery system, AG200-15: a randomized controlled trial.

    abstract:BACKGROUND:This study evaluated the ethinyl estradiol (EE) and levonorgestrel (LNG) pharmacokinetic profiles of AG200-15, a transdermal contraceptive delivery system, compared with a combination oral contraceptive (COC) containing EE 35 mcg and norgestimate 250 mcg. STUDY DESIGN:A Phase 1, open-label, single-center st...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2011.10.006

    authors: Archer DF,Stanczyk FZ,Rubin A,Foegh M

    更新日期:2012-06-01 00:00:00

  • Comparative study of the effects of two once-a-month injectable steroidal contraceptives (Mesigyna and Cyclofem) on lipid and lipoprotein metabolism. United Nations Development Programme/United Nations Population Fund/World Health Organization/World Bank,

    abstract::A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors:

    更新日期:1997-10-01 00:00:00

  • Vaginal swab specimen processing methods influence performance of rapid semen detection tests: a cautionary tale.

    abstract:BACKGROUND:Detection of semen biomarkers in vaginal fluid can be used to assess women's recent exposure to semen. Quantitative tests for detection of prostate-specific antigen (PSA) perform well, but are expensive and require specialized equipment. We assessed two rapid immunochromatographic strip tests for identificat...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.02.022

    authors: Hobbs MM,Steiner MJ,Rich KD,Gallo MF,Warner L,Macaluso M

    更新日期:2010-09-01 00:00:00

  • Medication Abortion Up to 70 Days of Gestation.

    abstract::Medication abortion, also referred to as medical abortion, is a safe and effective method of providing abortion. Medication abortion involves the use of medicines rather than uterine aspiration to induce an abortion. The U.S. Food and Drug Administration (FDA)-approved medication abortion regimen includes mifepristone...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.08.004

    authors: Practice Bulletins—Gynecology, the Society of Family Planning.

    更新日期:2020-10-01 00:00:00

  • Comparison of medical abortion follow-up with serum human chorionic gonadotropin testing and in-office assessment.

    abstract:BACKGROUND:The study was conducted to compare lost to follow-up (LTFU) rates in women having a medical abortion who chose follow-up by in-office ultrasound assessment or serum beta human chorionic gonadotropin (β-hCG) testing. METHODS:This retrospective chart review included 865 women who underwent medical abortion in...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.09.007

    authors: Horning EL,Chen BA,Meyn LA,Creinin MD

    更新日期:2012-04-01 00:00:00

  • Introduction of the pill and its impact.

    abstract::Introduction of the birth control pill in the United States in 1960 marked the end of a relatively short period of time (< 10 years) to intentionally produce an oral contraceptive, and the beginning of a relatively long period of controversy surrounding the use of the pill. Availability of the pill had an impact on va...

    journal_title:Contraception

    pub_type: 历史文章,杂志文章

    doi:10.1016/s0010-7824(98)00131-0

    authors: Tyrer L

    更新日期:1999-01-01 00:00:00