Abstract：
:The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women. Group 1 consisted of women not currently using oral contraceptives; Group 2 consisted of women switching to Femodene from their current oral contraceptive. Changes in lipid metabolism were assessed by measuring serum levels of cholesterol, triglycerides, LDL-C, VLDL-C, HDL-C, HDL2-C and HDL3-C. Minimal changes occurred in lipid metabolism apart from increases in triglyceride concentrations. Women in Group 1 showed a 105% increase in SHBG levels and a 51% increase in caeruloplasmin levels compared to increases of 33% and 2% in women in Group 2. A comparison of the two groups of women suggested that the gestagen in Femodene exerted a less anti-oestrogenic effect than most of the gestagens currently used in oral contraceptives. No significant changes occurred in liver function (assessed by estimation of gamma-glutamyl transferase) or in the coagulation factors, Factor X and antithrombin III. Minor effects on glucose tolerance as assessed by blood glucose and plasma insulin levels were noted. These minimal effects on metabolism, combined with its high efficacy and acceptability shown in clinical trials, makes Femodene an ideal alternative to currently used oral contraceptives.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Fotherby K,Trayner I,Longthorne PN,Lee B,Watson HRdoi
10.1016/0010-7824(87)90069-2subject
Has Abstractpub_date
1987-04-01 00:00:00pages
323-37issue
4eissn
0010-7824issn
1879-0518pii
0010-7824(87)90069-2journal_volume
35pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:This study examines contraceptive delivery characteristics and their association with contraceptive behavior. Data were collected in telephone interviews from a national sample of 1057 women who were using female contraceptives. The overwhelming majority of the sample obtained contraceptive services from gynecologists...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(89)90074-7
更新日期：1989-12-01 00:00:00
abstract：:Differential precipitation of plasma proteins after equilibration of the plasma with tracer amounts of testosterone (T) was used to measure free and not-T-estradiol binding globulin (TeBG)-bound T in 20 women and 10 men. Tritiated T was the tracer used. Comparison of this method with the equilibration dialysis metho...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90099-7
更新日期：1974-12-01 00:00:00
abstract：BACKGROUND:The study was conducted to compare lost to follow-up (LTFU) rates in women having a medical abortion who chose follow-up by in-office ultrasound assessment or serum beta human chorionic gonadotropin (β-hCG) testing. METHODS:This retrospective chart review included 865 women who underwent medical abortion in...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2011.09.007
更新日期：2012-04-01 00:00:00
abstract：:This study examines the efficacy and side effects of 15-methyl-prostaglandins F2alpha (PGF2a) free acid administered intramuscularly for midtrimester abortion. 50 healthy women aged 14 to 37 years and between 12 to 18 weeks gestation were randomly selected from the abortion clinic at the Los Angeles County/USC Medica...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(75)90107-9
更新日期：1975-05-01 00:00:00
abstract：:Abortion was attempted in 39 women in early pregnancy (less than 56 days amenorrhea) with the progesterone antagonist RU486 alone (150 mg per day for 4 days) or in combination with a PG analogue, 16,16-dimethyl-trans-delta 2-PGE1 (Gemeprost) in the form of a 1 mg vaginal pessary. Complete abortion was also attempted i...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(86)90055-7
更新日期：1986-11-01 00:00:00
abstract：:A number of case-control studies published in recent years have shown an apparent increase in the risk of venous thromboembolism (VTE) associated with the use of third-generation oral contraceptives (OCs) compared with second-generation OCs. However, it is thought that these studies were subject to a number of biases ...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/s0010-7824(00)00146-3
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with metabolic dysfunction and changes in cardiovascular risk markers, and using oral contraceptives (OCs) may exert a further negative effect on these alterations in patients with PCOS. Thus, the primary objective of this study was to asse...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2011.12.011
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Although widely used, the mechanisms of action of the levonorgestrel emergency contraceptive pill (LNG ECP) are still unclear. There are increasing data to indicate that LNG is particularly effective as an ECP by interrupting follicular development and ovulation. An important outstanding question is whether ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.contraception.2006.08.015
更新日期：2007-02-01 00:00:00
abstract：:The effect of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro-5-triazole (5,1a)-isoquinoline, a non-hormonal post-implantational anti-fertility drug, on tissue weights, nucleic acids and total protein concentrations in the testes, ventral prostate and seminal vesicles were evaluated in immature and sexually mature rats, while ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(87)90008-4
更新日期：1987-11-01 00:00:00
abstract：OBJECTIVES:Extensive data from clinical trials document mifepristone's safety and efficacy for induced abortion, but less information is available about its safety in routine clinical use. METHODS:Data on mifepristone abortion use from the Planned Parenthood Federation of America, the largest provider of mifepristone ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2005.03.011
更新日期：2005-09-01 00:00:00
abstract：:A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(89)80004-6
更新日期：1989-02-01 00:00:00
abstract：OBJECTIVE:To demonstrate the feasibility and safety of training midlevel healthcare providers (midwives and family nurses) to provide medical abortion and postabortion contraception in underserved areas in Kyrgyzstan. STUDY DESIGN:This was an implementation study at four referral facilities and 28 Felsher Obstetric Po...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.11.002
更新日期：2018-02-01 00:00:00
abstract：:The concentration of FSH, LH, testosterone and sperm agglutinating and cytotoxic antibodies have been determined in 87 men at varying time intervals after vasectomy. The results indicated that vasectomy is not associated with statistically significant changes in any of these parameters. Furthermore, no correlation exi...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(79)90007-6
更新日期：1979-06-01 00:00:00
abstract：OBJECTIVES:To assess clinician provision of hormonal contraception for HIV-positive and at-risk women in Southern Africa. STUDY DESIGN:We conducted a nationally representative survey of clinicians (n=1444) in HIV-prevalent settings in South Africa and Zimbabwe to evaluate evidence-based contraceptive care and clinicia...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.04.010
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVE:Single-visit intrauterine device (IUD) insertion protocols are recommended. We assessed the availability of single-visit IUD insertions, and whether access to these services varies by age, race or parity. STUDY DESIGN:Using audit study methodology, we called a random sample of 396 obstetrician-gynecology pra...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.05.007
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:This retrospective analysis evaluated the association of age and weight with cycle control in women using either of two formulations of low-estrogen-dose oral contraceptives. STUDY DESIGN:Data for this secondary analysis were derived from a randomized multicenter trial assessing the efficacy and safety of n...
journal_title：Contraception
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.contraception.2008.02.007
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:It can prove challenging to create social marketing materials aimed at a specific subsection of the population, especially when the topic is relatively new and possibly misunderstood. Therefore, the objective of this study was to assess adolescent knowledge of and attitudes towards emergency contraception (E...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.08.005
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:The objective was to describe the efficacy of medical abortion using mifepristone and misoprostol for gestations less than 6 weeks. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of mifepristone and misoprostol abortion at gestational ages <42 da...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.09.006
更新日期：2018-02-01 00:00:00
abstract：:Testosterone (T) treatment suppresses serum gonadotropins and reduces sperm output sufficiently for contraceptive efficacy in approximately 70% of Caucasian men. In the remaining 30% of men, an increase in 5alpha-reductase activity may maintain testicular androgen activity, thus accounting for the failure of sperm sup...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(00)00139-6
更新日期：2000-08-01 00:00:00
abstract：:A study was conducted to evaluate the effect of NORPLANT use on hemoglobin levels (HB), packed cell volume (PCV) and menstrual bleeding patterns. NORPLANT insertions were performed on 50 healthy volunteers in Ilorin, Nigeria, between January-March 1986. Whole blood samples were collected at admission, 6-month and 12-m...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(89)90059-0
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:To describe medroxyprogesterone acetate (MPA) levels among Kenyan depot medroxyprogesterone acetate (DMPA) users in the FEM-PrEP HIV prevention trial, and to compare MPA levels between ARV for HIV prevention (treatment) and placebo groups. STUDY DESIGN:We measured MPA in previously collected plasma samples f...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2016.03.003
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVES:This open-label non-inferiority study assessed efficacy of a common outpatient medical abortion regimen among people with pregnancies 64-70 days and 71-77 days of gestation. STUDY DESIGN:We defined non-inferiority by a 6% margin of method success. People with intrauterine pregnancies 64-77 days' gestational...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.01.009
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:Our objective was to explore knowledge, attitudes and beliefs about pregnancy and contraceptive decision-making among reproductive-aged women with cystic fibrosis. STUDY DESIGN:In this qualitative study, we used purposive sampling of reproductive age women enrolled in the Adult Cystic Fibrosis program at Pen...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.05.005
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Little is known about attitudes and beliefs among teenagers and young women about the intrauterine device (IUD). STUDY DESIGN:We surveyed 252 women, ages 14-27 years, presenting for appointments at an urban family planning clinic about demographics, sexual and birth control history, and opinions about the I...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2010.02.020
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:The risk of pregnancy is estimated to be 20 times as high among women who use oral contraception, and 90 times as high among condom users, as among women who use certain long-acting contraceptive methods. We explored the population-level implications of this variation in contraceptive efficacy. STUDY DESIGN...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2016.03.014
更新日期：2016-08-01 00:00:00
abstract：:Injection of a polymer, styrene maleic anhydride (SMA), into the lumen of the vas deferens of rats, was observed to have effective and reversible contraception. The safety evaluation of the polymer, for 90 days, was carried out in Charles Foster male rats. There have been no significant changes in any of the toxicity ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(89)80010-1
更新日期：1989-02-01 00:00:00
abstract：OBJECTIVE:To describe the efficacy, safety, and acceptability of medical abortion in the late first trimester. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of medical abortion at gestational ages (>63 to≤84 days gestation). We sought articles that compar...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.11.002
更新日期：2019-02-01 00:00:00
abstract：:After more than a century of reliance on latex condoms, male condoms fabricated from new materials are finally becoming commercially available to consumers. This study was an open label acceptability study that compared three lubricated condom products during vaginal intercourse: a natural rubber latex condom, a polyu...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(00)00119-0
更新日期：2000-06-01 00:00:00
abstract：PURPOSE:This study compared two oral contraceptives (OCs) with the same triphasic regimen of progestin (norgestimate 0.18, 0.215 and 0.25 mg) but differing doses of ethinyl estradiol (EE) - 25 and 35 microg EE - in their effects on androgens, mood and sexual interest in women starting on OCs. METHODS:Total testosteron...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2007.04.002
更新日期：2007-07-01 00:00:00
abstract：:Detailed information was collected from 666 cohorts of pill, injectable-DMPA and IUD acceptors at 14 Bangkok Metropolis Health Clinics (MHCs). The contraceptive status at 12-month follow-up home interview shows that 47% of pill acceptors, 39% of DMPA acceptors and 55% of IUD acceptors were still using the same contrac...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(84)80004-9
更新日期：1984-03-01 00:00:00
