Provision of medical abortion by midlevel healthcare providers in Kyrgyzstan: testing an intervention to expand safe abortion services to underserved rural and periurban areas.

Abstract:

OBJECTIVE:To demonstrate the feasibility and safety of training midlevel healthcare providers (midwives and family nurses) to provide medical abortion and postabortion contraception in underserved areas in Kyrgyzstan. STUDY DESIGN:This was an implementation study at four referral facilities and 28 Felsher Obstetric Points in two districts to train their midwives and family nurses to deliver safe and effective abortion care with co-packaged mifepristone-misoprostol and provide contraceptives postabortion. The outcome of abortion - complete abortion, incomplete abortion or o-going pregnancy - was the primary end point measured. An international consultant trained 18 midwives and 14 family nurses (with midwifery diplomas) to provide medical abortion care. Supervising gynecologists based in the referral centers and study investigators based in Bishkek provided monthly monitoring of services and collection of patient management forms. A voluntary self-administered questionnaire at the follow-up visit documented women's acceptability of medical abortion services. All study data were cross-checked and entered into an online data management system for descriptive analysis. RESULTS:Between August 2014 and September 2015, midwives provided medical abortion to 554 women with a complete abortion rate of 97.8%, of whom 62% chose to use misoprostol at home. No women were lost to follow-up. Nearly all women (99.5%) chose a contraceptive method postabortion; 61% of women receiving services completed the acceptability form, of whom more than 99% indicated a high level of satisfaction with the service and would recommend it to a friend. CONCLUSION:This study demonstrates that trained Kyrgyz midwives and nurses can provide medical abortion safely and effectively. This locally generated evidence can be used by the Kyrgyz Ministry of Health to reduce unintended pregnancy and expand safe abortion care to women in underserved periurban and rural settings. IMPLICATIONS:Success in scaling up midwife/nurse provision of medical abortion in Kyrgyzstan will require registration of mifepristone-misoprostol, regulations permanently allowing midwife/nurse provision, strengthened procurement and distribution systems to prevent stockouts of supplies, preservice training of midwives/nurses and their involvement in district level supervision, monitoring and reporting, and support from supervisors.

journal_name

Contraception

journal_title

Contraception

authors

Johnson BR Jr,Maksutova E,Boobekova A,Davletova A,Kazakbaeva C,Kondrateva Y,Landoulsi S,Lazdane G,Monolbaev K,Seuc Jo AH

doi

10.1016/j.contraception.2017.11.002

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

160-166

issue

2

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(17)30504-8

journal_volume

97

pub_type

杂志文章
  • Associations between recent contraceptive use and quality of life among women.

    abstract:BACKGROUND:Whether contraception affects health-related quality of life (HRQoL) is unclear. STUDY DESIGN:We conducted a cross-sectional analysis of routine intake data collected from women aged 18-50 years, including the RAND-36 (Research and Development Corporation) measure of HRQoL, pregnancy intentions and recent c...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.08.004

    authors: Williams SL,Parisi SM,Hess R,Schwarz EB

    更新日期:2012-03-01 00:00:00

  • Clinical utility of urine pregnancy assays to determine medical abortion outcome is limited.

    abstract:BACKGROUND:Determining medical abortion outcome commonly includes a costly evaluation such as ultrasonography or serial serum hCG testing. Urine pregnancy testing may represent a less costly alternative. METHODS:This prospective diagnostic test evaluation study was part of a multisite randomized trial of 1080 women un...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2007.01.021

    authors: Godfrey EM,Anderson A,Fielding SL,Meyn L,Creinin MD

    更新日期:2007-05-01 00:00:00

  • Four-year experience in a randomized study of the Gyne T 380 Slimline and the Standard Gyne T 380 intrauterine copper devices.

    abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(93)90107-i

    authors: Sivin I,Diaz J,Alvarez F,Brache V,Diaz S,Pavez M,Stern J

    更新日期:1993-01-01 00:00:00

  • Irregular bleeding, body mass index and coital frequency in Norplant contraceptive users.

    abstract::Seventy-five women with a mean age of 27.5 years who requested Norplant implants for contraception were studied over a five-year period. The patients kept daily diaries of their vaginal bleeding and coital frequency, and were seen at least every six months at which time their weight was measured. This study examines t...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(94)90047-7

    authors: Pasquale SA,Knuppel RA,Owens AG,Bachmann GA

    更新日期:1994-08-01 00:00:00

  • Nitrites and L-citrulline levels in copper intrauterine device users.

    abstract::The mechanism of copper in limiting intrauterine infections in intrauterine device (Cu IUD) users is poorly understood. Copper ions may enhance the release of reactive oxygen radicals, which in turn decrease the release of reactive nitrogen intermediates (RNI). RNI are known to have bactericidal effect. The present st...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(97)00037-1

    authors: Pradhan M,Gupta I,Ganguli NK

    更新日期:1997-05-01 00:00:00

  • A randomized study on the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on lipid and lipoprotein metabolism over a period of 13 cycles.

    abstract::In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (EE + DRSP = Yasmin), with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (EE + DSG = Marvelon) on the lipid profile. The prim...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.contraception.2003.11.003

    authors: Gaspard U,Endrikat J,Desager JP,Buicu C,Gerlinger C,Heithecker R

    更新日期:2004-04-01 00:00:00

  • Apoptosis occurs in implantation site of the rhesus monkey during early stage of pregnancy.

    abstract::The exact role of apoptosis that occurs in human placenta during the early stage of pregnancy remains unknown because of the difficulty in obtaining the intact implantation site. In this study, we used rhesus monkey as an animal model to examine apoptosis occurring in the implantation site at various stages of early p...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00241-4

    authors: Fei G,Peng W,Xin-Lei C,Zhao-Yuan H,Yi-Xun L

    更新日期:2001-09-01 00:00:00

  • Task-shifting the provision of DMPA-SC in the DR Congo: Perspectives from two different groups of providers.

    abstract:OBJECTIVES:To document the experience of three groups of Family Planning service providers participating in task-shifting for the provision of subcutaneous depot-medroxyprogesterone acetate (DMPA-SC) at the community level in the DRC. STUDY DESIGN:This article compares results from interviews with DMPA-SC providers in...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.07.002

    authors: Hernandez JH,Akilimali P,Glover A,Emel R,Mwembo A,Bertrand J

    更新日期:2018-11-01 00:00:00

  • IUD use in France: women's and physician's perspectives.

    abstract:OBJECTIVE:While the intra-uterine device (IUD) is the second most popular contraceptive method in France, its use remains low among women most at risk of unintended pregnancies. Acknowledging the conjoint role of women and physicians in contraceptive decision making, we investigate the determinants of IUD use and IUD r...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2013.10.003

    authors: Moreau C,Bohet A,Hassoun D,Ringa V,Bajos N,FECOND group.

    更新日期:2014-01-01 00:00:00

  • Evaluation of the effect of a patient decision aid about vasectomy on the decision-making process: a randomized trial.

    abstract:BACKGROUND:Between 7% and 10% of men who choose vasectomy as a contraceptive method regret their decision. This study evaluates the effect of a patient decision aid (PtDA) designed to help men decide whether or not to have a vasectomy. STUDY DESIGN:Men considering vasectomy were randomized to an experimental group tha...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2010.05.003

    authors: Labrecque M,Paunescu C,Plesu I,Stacey D,Légaré F

    更新日期:2010-12-01 00:00:00

  • Transfer of cyproterone acetate to the milk of lactating women.

    abstract::Cyproterone acetate (CPA) was administered in a dose of 50 mg to 6 lactating women delivered by caesarean section. All women had to discontinue breast feeding the day before treatment. Prior to, and 3 and 9 hours after ingestion of the drug, plasma and milk specimens were taken. Total daily milk volume was recorded. C...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90101-8

    authors: Stoppelli I,Rainer E,Hümpel M

    更新日期:1980-11-01 00:00:00

  • Women's out-of-pocket expenditures and dispensing patterns for oral contraceptive pills between 1996 and 2006.

    abstract:BACKGROUND:Little is known about the out-of-pocket expenditures and dispensing patterns for oral contraceptive pills (OCPs), factors associated with these outcomes and whether they change over time. STUDY DESIGN:Observational cohort using 1996-2006 Medical Expenditure Panel Surveys. RESULTS:Women spent $16 out-of-poc...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.09.013

    authors: Liang SY,Grossman D,Phillips KA

    更新日期:2011-06-01 00:00:00

  • Estimating systemic exposure to levonorgestrel from an oral contraceptive.

    abstract:OBJECTIVE:The gold standard for measuring oral contraceptive (OC) pharmacokinetics is the 24-h steady-state area under the curve (AUC). We conducted this study to assess whether limited sampling at steady state or measurements following use of one or two OCs could provide an adequate proxy in epidemiological studies fo...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2016.12.007

    authors: Basaraba CN,Westhoff CL,Pike MC,Nandakumar R,Cremers S

    更新日期:2017-04-01 00:00:00

  • Intra-amniotic prostaglandin PGF2alpha (THAM salt) and the laminaria tent in midtrimester termination of pregnancy.

    abstract::20 patients underwent intraamniotic administration of PGF2alpha for termination of pregnancies ranging from 14-20 weeks gestation. Success was achieved in 18 patients (90%) with this method. The 2 failures were terminated vaginally with adjunctive use of intracervical laminaria and intravenous pitocin induction. 10...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(74)90049-3

    authors: Berman R,Hale RW,Reich LA,Pion RJ

    更新日期:1974-06-01 00:00:00

  • Abortion referral patterns among generalist OB/GYNs and primary care practitioners: A qualitative study.

    abstract:OBJECTIVE:An informed, timely referral from a generalist practitioner has the potential to facilitate care for a patient seeking an abortion. However it is unclear what barriers, if any, generalist practitioners perceive in this process. The objective of this study was to qualitatively characterize abortion referral pa...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.10.009

    authors: Linton A,Mendez SR,Simon MA

    更新日期:2020-02-01 00:00:00

  • Effects of levonorgestrel-releasing intrauterine system on glucose and lipid metabolism: a 1-year follow-up study.

    abstract:PURPOSE:This prospective study aimed to assess the possible effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and fasting blood glucose levels over a period of 1 year. METHODS:Forty-eight premenopausal women, attending our gynecology clinic with the complaint of menorrhagia, were en...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.12.005

    authors: Kayikcioglu F,Gunes M,Ozdegirmenci O,Haberal A

    更新日期:2006-05-01 00:00:00

  • The postcoital IUD as an effective continuing contraceptive method.

    abstract::A two-year controlled clinical study of the effectiveness of postcoital IUD as a continuing contraceptive method in 98 women requesting a postcoital contraception is presented. The control group was selected from women requesting an IUD as contraceptive choice. The rates of accidental pregnancy, expulsion and removal ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(86)80011-7

    authors: Gottardi G,Spreafico A,de Orchi L

    更新日期:1986-12-01 00:00:00

  • Increasing access to safe abortion services in rural India: experiences with medical abortion in a primary health center.

    abstract:INTRODUCTION:To increase access to safe abortion in rural India, the feasibility and acceptability of mifepristone-misoprostol abortion was assessed in a typical government run primary health center (PHC) in Nagpur district, Maharashtra State, that does not offer surgical abortion services and must refer off-site for e...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2007.03.010

    authors: Mundle S,Elul B,Anand A,Kalyanwala S,Ughade S

    更新日期:2007-07-01 00:00:00

  • STS 557, a new orally active progestin with antiprogestational and contragestational properties in rabbits.

    abstract::STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone ad...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90140-7

    authors: Oettel M,Kurischko A

    更新日期:1980-01-01 00:00:00

  • Challenging the stereotypes: men, withdrawal, and reproductive health in Lebanon.

    abstract::In Lebanon, coitus interruptus or withdrawal remains a widely practiced method of family planning. Our research sought to understand the role of men in reproductive health in Lebanon by focusing on this common practice. Our main questions were: Why is it that the practice persists when more effective modern methods of...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00304-3

    authors: Myntti C,Ballan A,Dewachi O,El-Kak F,Deeb ME

    更新日期:2002-02-01 00:00:00

  • Five-year clinical experiences with NOVA T 380 copper IUD.

    abstract::In an open, single-group, phase III clinical trial of 5 years, the clinical performance of NOVA T 380 was investigated in three centers. The device having a higher copper surface of 380 mm(2) is a modification of NOVA T. A total of 400 voluntary women were enrolled in the study. The mean age was 31.4 years (SD 5.5) wi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/s0010-7824(02)00385-2

    authors: Batár I,Kuukankorpi A,Siljander M,Elomaa K,Rauramo I

    更新日期:2002-11-01 00:00:00

  • Long-term sequelae of tolnidamine on male reproduction and general body metabolism in rabbits.

    abstract::The long-term effects of tolnidamine on male reproduction and general body metabolism were studied in rabbits (Oryctolagus cuniculus). The study was divided into three groups of 10 animals each. The first group (A) received vehicle alone to serve as controls. The second and third groups (B and C) of animals were admin...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(98)00031-6

    authors: Ansari AS,Kumar Y,Srivastava S,Lohiya NK

    更新日期:1998-04-01 00:00:00

  • Short-term treatment with levonorgestrel does not antagonize the ethinyl estradiol-induced increase of uterine blood flow in postmenopausal women.

    abstract::The aim of this study was to determine the effect of a short-term ethinyl estradiol/levonorgestrel medication on blood flow in the uterine arteries in postmenopausal women in a prospective placebo-controlled double-blind study. Twenty-one healthy postmenopausal woman at least 2 years after menopause received 60 microg...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(97)00122-4

    authors: Entezami M,Heger-Mahn D,Ebert A,Halis G,Lübbert H

    更新日期:1997-09-01 00:00:00

  • Trends in nonresident abortion rates in New York City from 2005 to 2015: a time series analysis.

    abstract:OBJECTIVES:To examine trends and utilization patterns of NYC abortion services by nonresidents since growing abortion restrictions across many states could drive women to seek care in less restrictive jurisdictions including NYC. STUDY DESIGN:We used data from Induced Termination of Pregnancy certificates filed with t...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.05.008

    authors: Johansson EW,Argov EL,Langston A,Yager A,Searing H,Liu SY

    更新日期:2019-09-01 00:00:00

  • The protective influence of progestogen only contraception against vaginal moniliasis.

    abstract::The incidence of Candida albicans (C.A.) infection of the vagina was evaluated in vaginal discharges obtained from 85 subjects using a large battery of culture media and confirmatory tests. Twenty women using DMPA 150 mg i.m. contraceptive injections for more than one year (long-term users) were compared with forty 2n...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(79)90082-9

    authors: Toppozada M,Onsy FA,Fares E,Amir S,Shaala S

    更新日期:1979-08-01 00:00:00

  • A phase I study of Femcap used with and without spermicide. Postcoital testing.

    abstract::The objectives of the study were to assess the ability of the Femcap, a new vaginal contraceptive device made of silicone and designed to fit snugly around the cervix to prevent the penetration of sperm into midcycle cervical mucus when used with and without spermicide; and to compare it with the standard contraceptiv...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(97)00098-x

    authors: Mauck CK,Baker JM,Barr SP,Johanson W,Archer DF

    更新日期:1997-08-01 00:00:00

  • Abortion misinformation from crisis pregnancy centers in North Carolina.

    abstract:BACKGROUND:This study assessed the accuracy of medical information provided by crisis pregnancy centers in North Carolina. STUDY DESIGN:We performed a secondary data analysis of a "secret shopper survey" performed by a nonprofit organization. Reports from phone calls and visits to crisis pregnancy centers were analyze...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.contraception.2012.06.001

    authors: Bryant AG,Levi EE

    更新日期:2012-12-01 00:00:00

  • Metabolic investigations with Femodene--an oral contraceptive containing gestodene and ethinyloestradiol.

    abstract::The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women. Group 1 consisted of women not currently using oral contraceptives; Group 2 consisted of women switching to Femoden...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(87)90069-2

    authors: Fotherby K,Trayner I,Longthorne PN,Lee B,Watson HR

    更新日期:1987-04-01 00:00:00

  • A qualitative study of digoxin injection before dilation and evacuation.

    abstract:OBJECTIVE:We sought to qualitatively understand patients' experiences with digoxin as a step before dilation and evacuation (D&E). STUDY DESIGN:We recruited English-speaking women from one abortion health center where digoxin is routinely used before D&E. We interviewed participants one to three weeks after the D&E ab...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.02.004

    authors: McNamara B,Russo J,Chaiken S,Jacobson J,Kerns J

    更新日期:2018-06-01 00:00:00

  • Weight and body mass index among female contraceptive clients.

    abstract:OBJECTIVES:As obesity may affect the efficacy of some contraceptives, we examined weight, body mass index (BMI) and prevalence of obesity among female contraceptive clients at 231 U.S. health centers. A secondary aim was to analyze differences in contraceptive method use by obesity status. STUDY DESIGN:Cross-sectional...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.02.006

    authors: Kohn JE,Lopez PM,Simons HR

    更新日期:2015-06-01 00:00:00