Abstract:
:The objectives of the study were to assess the ability of the Femcap, a new vaginal contraceptive device made of silicone and designed to fit snugly around the cervix to prevent the penetration of sperm into midcycle cervical mucus when used with and without spermicide; and to compare it with the standard contraceptive diaphragm used with spermicide. Eight women underwent two baseline cycles of postcoital testing in which no device was used, followed by three test cycles in which Femcap with spermicide, Femcap with nonspermicidal lubricant (K'Y gel) or the Ortho All-Flex diaphragm with spermicide was used. The sequence of testing cycles was randomized. In each cycle, condoms were used prior to midcycle, then a midcycle cervical mucus specimen was examined to ensure midcycle characteristics and the absence of sperm. Each woman then had intercourse using either no device (baseline cycles) or the prescribed device (test cycles) and returned 2-3 h afterwards. Cervical mucus was again assessed for adequacy and the presence of spermatozoa. The average number of progressively motile sperm seen per high power field was as follows: first baseline cycle, 18.0; second baseline cycle, 17.8; test cycle with Femcap used with nonspermicidal lubricant, 0.1; test cycle with Femcap used with spermicide, 0.2; and test cycle with the diaphragm used with spermicide, 0.0. There was no significant difference between baseline cycles or among test cycles in the average number of progressively motile sperm seen (p > 0.05). The average number of progressively motile sperm seen in each test cycle did, however, differ significantly from the average number seen in either baseline cycle (p < 0.05). Femcap, used with either a spermicidal lubricant or a nonspermicidal lubricant, appears to be comparable with the diaphragm used with spermicide in preventing sperm from entering midcycle cervical mucus. :A Phase I postcoital study assessed the capability of Femcap, a new vaginal contraceptive device made of silicone, to prevent sperm from entering midcycle cervical mucus. After 2 baseline cycles of postcoital testing in which no device was used, 8 US women underwent 3 test cycles in which Femcap with spermicide, Femcap with a nonspermicidal lubricant (KY gel), or the Ortho All-Flex diaphragm with spermicide was used. The sequence of testing cycles was randomized. The average number of progressively motile sperm seen per high power field was as follows: first baseline cycle, 18.0; second baseline cycle, 17.8; test cycle with Femcap used with nonspermicidal lubricant, 0.1; test cycle with Femcap used with spermicide, 0.2; and test cycle with the diaphragm used with spermicide, 0.0. These findings indicate that Femcap, used with either a spermicide or a nonspermicidal lubricant, is comparable to the diaphragm in terms of its ability to prevent the penetration of sperm into midcycle cervical mucus.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Mauck CK,Baker JM,Barr SP,Johanson W,Archer DFdoi
10.1016/s0010-7824(97)00098-xsubject
Has Abstractpub_date
1997-08-01 00:00:00pages
111-5issue
2eissn
0010-7824issn
1879-0518pii
S001078249700098Xjournal_volume
56pub_type
临床试验,杂志文章,随机对照试验相关文献
CONTRACEPTION文献大全abstract:OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.06.004
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Intrauterine contraception (IUC) is safe, highly effective and has few medical contraindications. Primary care providers see many women with chronic conditions who might benefit from IUC. STUDY DESIGN:We surveyed women aged 18-50 who visited one of four primary care clinics in Pennsylvania between October 2...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.02.004
更新日期:2013-08-01 00:00:00
abstract::A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1997-10-01 00:00:00
abstract::The effect of propanolol hydrochloride (PH) and oxprenolol hydrochloride (OH) on ovulation was studied in mature rabbits. PH-treated animals did not accept mating and ovulation was suppressed after forced mating. 5 of 6 OH-treated animals refused mating. No implantation sites or corpora lutea were found in the anim...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(75)80036-9
更新日期:1975-07-01 00:00:00
abstract:OBJECTIVE:To compare time from misoprostol initiation to fetal expulsion for mifepristone-misoprostol versus misoprostol-alone regimens of medication abortion performed at ≥24 weeks' gestation. STUDY DESIGN:We conducted a retrospective study of medication abortion performed at ≥24 weeks' gestation between May 2016 and...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.05.001
更新日期:2020-08-01 00:00:00
abstract::The mechanism of action of intrauterine devices varies from one type of device to another, although the principle of action is the same, namely, to interfere with the physiology of reproduction at the endometrial level. The biochemical changes of the endometrial tissue and the composition of the uterine fluid have bee...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(87)90058-8
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of miPlan, a waiting-room contraceptive counseling mobile application (app), on interest in discussing long-acting reversible contraception (LARC) during the clinical encounter and LARC uptake. STUDY DESIGN:This randomized controlled trial evaluated the miPlan contraceptive counseling ...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2018.07.001
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:We examine the lifetime and past-year prevalence and circumstances of unprotected intercourse among members of the Society of Family Planning (SFP), a professional reproductive health organization in the United States. STUDY DESIGN:We invited the membership of SFP (n=477) via email to participate in an anon...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.04.004
更新日期:2015-07-01 00:00:00
abstract::The effects of phenytoin treatment on plasma concentrations of norethisterone (NET) was studied in 7 healthy female rhesus monkeys. Before phenytoin treatment was started each monkey received an oral dose of 0.5 mg NET and 2 weeks later the same dose was given intravenously. On both occasions, plasma concentrations of...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(83)80021-3
更新日期:1983-04-01 00:00:00
abstract::Effect of RISUG, a newly developed male contraceptive, on various amino acids of seminal plasma ejaculates was studied by proton magnetic resonance spectroscopy at 400 MHz. Levels of amino acids were compared with the seminal plasma of obstructive azoospermia and controls. Glutamic acid, glutamine, and arginine were f...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00343-8
更新日期:2002-09-01 00:00:00
abstract::A structured literature review was undertaken to determine, in the context of early medical abortion, the proportion of women who require analgesia, the predictors of analgesia requirement and the most appropriate analgesia regimen. Studies from different centers show wide variations in analgesia use, but, overall, ar...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2006.03.002
更新日期:2006-07-01 00:00:00
abstract::Changes in the physical characteristics of semen and ultrastructure of the spermatozoa of langur monkeys after vas occlusion with styrene maleic anhydride (SMA), a polymer with pH-lowering action, are reported. Vas occlusion resulted in severe reversible hypospermia. Severe oligospermia was observed in the majority of...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(98)00011-0
更新日期:1998-02-01 00:00:00
abstract::After exposure of young male rats to gossypol acetic acid for various times, a reduction in the content of cellular and microtubular beta-tubulin was found in spermatocytes and spermatids. The content of tubulin was measured by enzyme-linked immunosorbent assay (ELISA). The results were expressed as micrograms tubulin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(96)00240-5
更新日期:1997-01-01 00:00:00
abstract::This study examined the effect of epostane, a new antifertility drug, on normal and hCG-stimulated progesterone production during the luteal phase of the menstrual cycle in rhesus monkeys. When administered once each day for five days, epostane inhibited normal luteal phase progesterone levels in a dose-related fashio...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(85)90083-6
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:This study was conducted to compare breast epithelial-cell proliferation and estrogen and progesterone receptor levels in women taking one of two oral contraceptives (OCs) containing the same dose of estrogen but different doses of the progestin norethindrone (NET). STUDY DESIGN:Thirty-three women were rand...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2011.12.015
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:To develop and validate standardized criteria for assessing abortion-related incidents (adverse events, morbidities, near misses) for first-trimester aspiration abortion procedures and to demonstrate the utility of a standardized framework [the Procedural Abortion Incident Reporting & Surveillance (PAIRS) Fr...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2017.05.004
更新日期:2017-07-01 00:00:00
abstract::Ethylene-vinyl acetate (EVA) polymeric contraceptive implants (Implanon) containing 3-keto-desogestrel have been prepared aiming at an in vitro initial release rate of 60 micrograms 3-keto-desogestrel/day. These implants are designed to have an intended life-time of 2 years. During a 3-year period, the release of thes...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(93)90093-m
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:The objective was to understand the motivations around and practices of abortion referral among women's health providers. METHODS:We analyzed the written comments from a survey of Nebraska physicians and advanced-practice clinicians in family medicine and obstetrics-gynecology about their referral practices ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.01.007
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:Positive effects on premenstrual symptoms have been observed with low-dose oral contraceptives. Drospirenone is a synthetic progestogen with antiandrogenic and antimineralocorticoid effects. This open-label, multicenter study evaluated the effects of a combination of ethinylestradiol 30 microg and drospirenone ...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.contraception.2005.10.016
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:Our objective was to explore knowledge, attitudes and beliefs about pregnancy and contraceptive decision-making among reproductive-aged women with cystic fibrosis. STUDY DESIGN:In this qualitative study, we used purposive sampling of reproductive age women enrolled in the Adult Cystic Fibrosis program at Pen...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.05.005
更新日期:2019-09-01 00:00:00
abstract:UNLABELLED:The World Health Organization (WHO) and the US Centers for Disease Control and Prevention (CDC) provide recommendations for use of emergency contraceptive pills (ECPs), including levonorgestrel (LNG) and combined oral contraceptives (COCs). A new ECP formulation, ulipristal acetate (UPA), is now available wo...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2015.11.001
更新日期:2016-02-01 00:00:00
abstract::The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(85)90108-8
更新日期:1985-08-01 00:00:00
abstract::Emergency contraception promises to reduce Mexico's high unwanted pregnancy and unsafe abortion rates. Because oral contraceptives are sold over-the-counter, several emergency contraceptive regimens are already potentially available to those women who know about the method. Soon, specially packaged emergency contracep...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(99)00088-8
更新日期:1999-10-01 00:00:00
abstract::A cross-sectional study was conducted to investigate the prevalence, type and severity of domestic violence (DV), and determine the factors related to DV among women seeking induced abortion in China. A total of 1215 women seeking induced abortion were interviewed. The results show that the prevalence of DV among part...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.02.010
更新日期:2005-08-01 00:00:00
abstract::With an ever-increasing number of reproductive-aged women undergoing solid organ transplant and fertility improving after transplant, knowledge of the safety and efficacy of various contraceptive methods is essential to guide patient selection. We present the case of a 22-year-old patient desiring an intrauterine devi...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2019.05.012
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The benefits of social support in post-surgical recovery are well documented; social support decreases preoperative stress and postoperative recovery time. However, a paucity of studies have examined the effect of social support in the context of pregnancy termination. This study is the first to examine the ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.07.019
更新日期:2011-03-01 00:00:00
abstract::Experiments were conducted to determine whether oral administration of a water extract of P. dodecandra had significant effects on reproduction in mice. The work is based on earlier reports in this journal that butanol extracts of the berries of this plant had spermatocidal properties in vitro and blastocidal activity...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(87)80006-9
更新日期:1987-02-01 00:00:00
abstract::The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(87)90077-1
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVES:This open-label non-inferiority study assessed efficacy of a common outpatient medical abortion regimen among people with pregnancies 64-70 days and 71-77 days of gestation. STUDY DESIGN:We defined non-inferiority by a 6% margin of method success. People with intrauterine pregnancies 64-77 days' gestational...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.01.009
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:As obesity may affect the efficacy of some contraceptives, we examined weight, body mass index (BMI) and prevalence of obesity among female contraceptive clients at 231 U.S. health centers. A secondary aim was to analyze differences in contraceptive method use by obesity status. STUDY DESIGN:Cross-sectional...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.02.006
更新日期:2015-06-01 00:00:00