Abstract：
:This study examined the effect of epostane, a new antifertility drug, on normal and hCG-stimulated progesterone production during the luteal phase of the menstrual cycle in rhesus monkeys. When administered once each day for five days, epostane inhibited normal luteal phase progesterone levels in a dose-related fashion. Epostane also reduced the elevated luteal phase progesterone levels of animals treated with hCG indicating that the drug acts directly on the corpus luteum. These data suggest that epostane interferes with corpus luteum function in a primate and that the drug would be effective as an interceptive agent during early pregnancy.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Snyder BW,Schane HPdoi
10.1016/0010-7824(85)90083-6subject
Has Abstractpub_date
1985-05-01 00:00:00pages
479-86issue
5eissn
0010-7824issn
1879-0518pii
0010-7824(85)90083-6journal_volume
31pub_type
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