Abstract:
:Changes in the physical characteristics of semen and ultrastructure of the spermatozoa of langur monkeys after vas occlusion with styrene maleic anhydride (SMA), a polymer with pH-lowering action, are reported. Vas occlusion resulted in severe reversible hypospermia. Severe oligospermia was observed in the majority of animals (five of eight) in the first ejaculation, 30 days after vas occlusion, and in two animals in the second ejaculation, 60 days after vas occlusion. Subsequent monthly ejaculations for 5 months revealed uniform azoospermia. The voided spermatozoa were immotile and supravital staining confirmed necrospermia. Scanning electron microscopy (SEM) revealed severe coiling of tail, rupture of acrosomal envelope, and bent midpiece associated with damaged mitochondrial sheath. Observations by transmission electron microscopy (TEM) revealed vacuolization in the nucleus, membrane damage in the acrosome, loss of segmented columns, and numeric aberrations in the centriole of the neck, as well as degeneration of mitochondrial sheath and axoneme in the midpiece, and absence of outer plasma membrane in the midpiece and tail. The results indicate that the necrospermic status of the spermatozoa during initial ejaculations may offer instant sterility after vas occlusion with SMA.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Lohiya NK,Manivannan B,Mishra PKdoi
10.1016/s0010-7824(98)00011-0subject
Has Abstractpub_date
1998-02-01 00:00:00pages
125-32issue
2eissn
0010-7824issn
1879-0518pii
S0010-7824(98)00011-0journal_volume
57pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract::Blood pyrodoxine hydrochloride (vitamin-B6) concentration was determined in 50 women using combined oral contraceptives (OCs), 24 women who received an intramuscular injection of 150 mg medroxyprogesterone acetate (MPA) every 12 weeks, and in 14 women who used an intrauterine device (IUD) at the out-patient contracep...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(74)90078-x
更新日期:1974-04-01 00:00:00
abstract::The effect of eight common local mineral water drinks in Ile-Ife, Nigeria (seven cola and one lemon-based) on sperm motility in vitro was carried out. There was no significant difference in the pH values of all the drinks, the pH ranged between 2.30-2.50. After one minute, Pepsi-Cola had the least inhibitory effect on...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(87)90092-8
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Determining medical abortion outcome commonly includes a costly evaluation such as ultrasonography or serial serum hCG testing. Urine pregnancy testing may represent a less costly alternative. METHODS:This prospective diagnostic test evaluation study was part of a multisite randomized trial of 1080 women un...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2007.01.021
更新日期:2007-05-01 00:00:00
abstract::To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed ...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(96)00174-6
更新日期:1996-09-01 00:00:00
abstract::Oral contraceptives (OCs) have been shown to effectively treat acne. Clinical trials of various doses of ethinyl estradiol (EE) combined with progestins such as levonorgestrel, desogestrel, norgestimate, gestodene, cyproterone acetate and drospirenone in monophasic, triphasic and combiphasic formulations used to treat...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2005.07.010
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Healthy People 2020 establishes objectives for reducing the proportion of pregnancies in the United States that are unintended and for improving contraceptive use. This analysis describes ways to more closely align measurement of contraceptive use with periods of risk for unintended pregnancy using the Natio...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.04.009
更新日期:2020-08-01 00:00:00
abstract::We evaluated the efficacy and side effects of immediate postcoital administration of levonorgestrel 0.75 mg used repeatedly for contraception. A total of 295 healthy women with infrequent coitus were enrolled at 6 study sites. Each woman took levonorgestrel 0.75 mg by mouth immediately after intercourse during 6 month...
journal_title:Contraception
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the pharmacokinetic and pharmacodynamic effects of two novel levonorgestrel (LNG)-only contraceptive patches. STUDY DESIGN:This multi-center Phase I/II trial randomized participants to use a 7-day transdermal patch designed to deliver a 40 mcg or 75 mcg daily LNG dose for 11 consecutive weeks; r...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.04.007
更新日期:2018-04-18 00:00:00
abstract:OBJECTIVE:To estimate the effect of increased body weight and body mass index (BMI) on pregnancy rates with levonorgestrel (LNG) 1.5mg used as emergency contraception (EC). METHODS:The study reviewed data from 6873 women in four WHO-HRP randomized trials on EC conducted between 1993 and 2010. Participants took either ...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2016.08.001
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Fear of adverse effects on subsequent fertility following reversible contraceptive use is an important concern for some women. STUDY DESIGN:We undertook a comprehensive and objective review of the literature for prospective studies reporting pregnancy rates in women following contraceptive cessation. One-ye...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2011.04.002
更新日期:2011-11-01 00:00:00
abstract::Community-based distribution (CBD) programs are the optimum way of reaching people in rural areas of developing countries where conventional methods of delivery do not exist or fail. This paper reviews findings and experiences from over 30 years of efforts to implement CBD of family planning methods around the world. ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2005.06.059
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Within the setting of a UK community sexual health service, the cost-effectiveness of Implanon and oral contraception provision over a 36-month period was compared. STUDY DESIGN:A case-controlled retrospective cost-effectiveness study was done on a cohort of 493 Implanon users and 493 oral contraceptive use...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2008.11.003
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of outpatient medical abortion with mifepristone 200 mg and two misoprostol 800 mcg doses at 64-70 and 71-77 days of gestation. STUDY DESIGN:We conducted a retrospective chart review of medical abortion outcomes among clients with 64-77 day gestations at a Mexico City public clin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.05.012
更新日期:2020-08-01 00:00:00
abstract::The mode of antifertility action of intrauterine neem treatment (IUNT) was studied. The effect of IUNT on ovarian functions and uterine responsiveness to ovarian hormones was examined in adult Wistar rats. The treated animals had normal reproductive cycles as indicated by the vaginal smears; serum progesterone levels ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(95)00018-6
更新日期:1995-03-01 00:00:00
abstract::The overall and renal toxicity of racemic gossypol acetic acid was assessed in 6 mongrel dogs. Oral racemic gossypol acetic acid was given orally at doses increasing from 10 to 40 mg/d for a total of 6 weeks in 3 female dogs and from 40 to 80 mg/d for a total of 4 weeks in 3 male dogs. The animals were then sacrificed...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(88)90127-8
更新日期:1988-02-01 00:00:00
abstract::Levels of immunoreactive follitropin (FSH), lutropin (LH), estradiol, progesterone, 17-hydroxyprogesterone and 20 alpha-dihydroprogesterone were analyzed in peripheral plasma samples collected daily from 21 normally menstruating women during a pretreatment (control) cycle and during months 2 and 6 of administration of...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90049-4
更新日期:1981-03-01 00:00:00
abstract::The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(85)90108-8
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:This study was conducted to assess the efficacy and incidence of side effects of a regimen of repeated doses of 400 microg sublingual misoprostol for termination of pregnancy of <7 weeks gestation. METHOD:Fifty women were given 400 microg sublingual misoprostol every 3 h for three doses. Two additional dose...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(03)00134-3
更新日期:2003-08-01 00:00:00
abstract::Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm o...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0010-7824(95)00263-4
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Music has served as an auxiliary analgesic in perioperative settings. This study evaluates the impact of intraoperative music added to routine pain control measures during first trimester surgical abortion. STUDY DESIGN:We analyzed data from 101 women randomized to undergo abortion with routine pain control...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2011.11.017
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Maternal trisomy 21 ovarian mosaicism might provide the major causative factor for fetal Down syndrome. The small proportion of trisomy 21 oocytes thought to be retarded in their maturation in comparison to normal disomic ones, and the maternal age effect can be based on an accumulation of trisomy 21 oocytes...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.08.040
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:Combined oral contraceptives (COCs) decrease testosterone (T) levels. This study investigated restoration of T and other androgen concentrations during COC use by 'co-administration' of dehydroepiandrosterone (DHEA). STUDY DESIGN:In this randomized, double-blind, placebo-controlled study in 99 new COC start...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2014.11.002
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The study was conducted to evaluate ethinyl estradiol (EE) or ibuprofen (IBU) compared to placebo (PL) on spotting and bleeding (S/B) and a postcoital test (PCT) in women using the levonorgestrel subcutaneous implant. Women experiencing excessive S/B were enrolled in a multicenter prospective randomized stud...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2008.04.003
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:To compare pain levels and medication needs after placement of laminaria vs Dilapan-S, and after dilation and evacuation (D&E). STUDY DESIGN:We conducted a single-blinded randomized control trial of patients undergoing D&E at 15 0/7 to 23 6/7 weeks gestation, randomizing to cervical preparation with laminar...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.11.014
更新日期:2020-12-04 00:00:00
abstract::A questionnaire study was carried out to investigate the needs of women undergoing a medical abortion induced by mifepristone in combination with either gemeprost pessaries or oral misoprostol. One-hundred-and-eighty women undergoing medical abortion of pregnancy of up to 63 days amenorrhoea were randomised to treatme...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(92)90147-l
更新日期:1992-11-01 00:00:00
abstract::A triphasic oral contraceptive containing ethinyl estradiol and gestodene was used by 1933 women for up to 36 cycles in order to evaluate contraceptive efficacy, general tolerance and cycle control. Altogether, 30,763 treatment cycles were recorded. Two pregnancies were seen, both of them classified as user failure. T...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0010-7824(92)90128-g
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Cyclofem is a combined injectable contraceptive, containing medroxyprogesterone acetate (MPA) and estradiol cypionate. The objective was to characterize the steady-state pharmacokinetics (PK) using tandem liquid chromatography/mass spectrometry and compare these data to a previous PK study of this formulatio...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.11.010
更新日期:2013-06-01 00:00:00
abstract::The metabolism of isotopically labeled ethinyl estradiol (EE) and mestranol (ME) was studied in 3 baboons before and after the simultaneous injection of a norethindrone-mestranol contraceptive formulation. 6 days after the administration of tritiated-EE and carbon-14-ME, the mean urinary excretion of labeled-EE was 3...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(77)90116-0
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:In 2013, Texas House Bill 2 (HB 2) placed restrictions on the use of medication abortion, which later were nullified with the 2016 FDA-approved mifepristone label. METHODS:Using data collected directly from Texas abortion facilities, we evaluated changes in the provision and use of medication abortion durin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.01.001
更新日期:2019-05-01 00:00:00
abstract::There is considerable variation in opinion about the importance of drug interactions between the combined oral contraceptive pill (COCP) and broad-spectrum antibiotics. Clinical practice varies widely, especially between doctors in Europe and those in the US. Rifampicin and griseofulvin induce hepatic enzymes and do a...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/s0010-7824(99)00009-8
更新日期:1999-02-01 00:00:00