Abstract：
:The overall and renal toxicity of racemic gossypol acetic acid was assessed in 6 mongrel dogs. Oral racemic gossypol acetic acid was given orally at doses increasing from 10 to 40 mg/d for a total of 6 weeks in 3 female dogs and from 40 to 80 mg/d for a total of 4 weeks in 3 male dogs. The animals were then sacrificed. Drug tolerance was excellent. Pathological examination of the liver and heart was normal. Renal function remained normal. The renal excretion of K, Mg, phosphate and acid remained normal. Serum K remained within the range appropriate for animals on a K-free diet. Pathological examination of the kidney disclosed mild proximal tubule vacuolization similar to that observed in animals on a K-free diet and small brownish pigment deposits in a few tubular cells. Spermatogenesis was arrested in the testes of one of the 3 male dogs. We conclude that short exposure to 10 to 80 mg/day of gossypol does not result in detectable toxic effect. Neither significant hypokalemia nor a tubular K leak were observed.
journal_name
Contraceptionjournal_title
Contraceptionauthors
van Ypersele de Strihou C,Dieu JP,Marbaix Edoi
10.1016/0010-7824(88)90127-8subject
Has Abstractpub_date
1988-02-01 00:00:00pages
173-7issue
2eissn
0010-7824issn
1879-0518pii
0010-7824(88)90127-8journal_volume
37pub_type
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