Combined hormonal contraception and bone health: a systematic review.

Abstract:

:This systematic review examined whether women who use combined hormonal contraception experience changes in risk of fracture or bone mineral density (BMD) that differ from nonusers. We identified 86 articles from PubMed and EMBASE (published 1966 to August 2005) that reported on fracture or BMD outcomes by use of combined hormonal contraceptives. The evidence relating to combined oral contraceptives (COCs) and fracture is inconclusive, as results from the available studies conflict. Studies of adolescent and young adult women generally found lower BMD among COC users than nonusers. Evidence for premenopausal adult women suggested no differences in BMD between COC users and nonusers. COC use in perimenopausal and postmenopausal women preserved bone mass, while nonusers lost BMD, but BMD among former COC users in this age group was the same as for never-users. Evidence for other combined hormonal methods was very limited, with one study indicating no effect of combined hormonal injectable use among premenopausal women on BMD and one study suggesting lower BMD among premenopausal users of the NuvaRing than in nonusers.

journal_name

Contraception

journal_title

Contraception

authors

Martins SL,Curtis KM,Glasier AF

doi

10.1016/j.contraception.2006.01.003

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

445-69

issue

5

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(06)00009-6

journal_volume

73

pub_type

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