Abstract:
BACKGROUND:The aim of this study was to explore a new three-dimensional, reticular intrauterine device (3-DRIUD) composed of nitinol and silicone rubber and to observe the contraceptive effect of the device in rats. STUDY DESIGN:Two contraceptive experiments were performed. In the first, female rats underwent bilateral placement of a 20.0-35.0-mm 3-DRUID (experimental group, n=30) via an abdominal incision or a sham operation with no IUD (control group, n=30). Two weeks after the operation was performed, the rats from either group were caged together with male rats. The contraceptive effects of the 3-DRIUD were observed at 1 to 3 months postoperation, after which the 3-DRIUDs were removed. One month after this second operation, the rats from the two groups were again coupled with fertile male rats. In a second experiment, female rats underwent bilateral placement of a 10.0-mm 3-DRUID (n=5) via an abdominal incision or a two-dimensional IUD (2-DIUD, n=20) and mated 1 month after surgery. The single-pipeline IUD was placed in 10 rats, while the enfolded-pipeline IUD was placed in 10 different rats. RESULTS:In the first experiment, none of the females in the experimental 3-DRIUD group became pregnant (0/30, 0%) after 3 months, compared to 28/30 (93.3%, p<.0001) rats in the control group. After the 3-DRIUDs were removed from the experimental group after 3 months, 27/30 (90%) became pregnant, compared with 29/30 (97%, p>.05). The litter size (mean±SD) did not differ between groups (10.9±1.5 3-DRUID, 11.2±1.1 control, p>.05). In the second experiment, five rats had a 10.0-mm 3-DRUID (which was one third the length of one uterine horn) inserted into the bilateral uterine horns, and three of the five rats became pregnant. All 20 rats were pregnant 1 month after the insertion of the 2-DIUD. Thus, the contraceptive rate for the 2-DIUD group was 0. CONCLUSIONS:The primary contraceptive mechanism effect of the new 3-DRIUD in rodents appears to be a result of occupying physical space in the uterus.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Qiu Y,Wang LG,Zhang MH,Zhang YP,Zhang AD,Yang DTdoi
10.1016/j.contraception.2012.10.031subject
Has Abstractpub_date
2013-07-01 00:00:00pages
31-6issue
1eissn
0010-7824issn
1879-0518pii
S0010-7824(12)00962-6journal_volume
88pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract:OBJECTIVES:We aimed to determine the efficacy of fennel and low-dose combined oral contraceptive (LD-COC) on inducing menstrual bleeding and method continuation in women using depot medroxyprogesterone acetate (DMPA) who had no menstrual bleeding within the previous 45 to 140 days. STUDY DESIGN:In this double-blind do...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2014.05.001
更新日期:2014-10-01 00:00:00
abstract::The discovery of the reversible antifertility action of an extract from Tripterygium wilfordii both in male rats and in men in 1986 stimulated worldwide interest. International and national collaborations aimed at the bioassay-directed sub-fractionation of materials extracted from the plant was then organized and to d...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(94)00018-r
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVES:The present study aims to prospectively evaluate quality of life (QoL) of women using 52-mg levonorgestrel intrauterine system (LNG-IUS) for contraception determined through the Sociedad Española de Contracepción (Spanish contraception Society) (SEC)-QoL, a questionnaire specifically designed to assess the i...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/j.contraception.2015.12.014
更新日期:2016-04-01 00:00:00
abstract::In a prospective, randomised dose-finding study involving 60 women scheduled for termination of 1st trimester pregnancy, 25 micrograms, 50 micrograms or 100 micrograms of a sulprostone gel with a constant injection volume of 2.5 ml were applied intracervically 6-8 hours before curettage. The gelatinising agent was Plu...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(85)90091-5
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:Given the need for a 90-day post-Essure hysterosalpingogram (HSG) to confirm proper tubal placement and occlusion, we examined the impact of dedicating a staff nurse to schedule HSG appointments, call with appointment reminders and track HSG compliance for patients who had Essure. STUDY DESIGN:We performed ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.01.019
更新日期:2010-06-01 00:00:00
abstract::A randomized comparative study between Nova-T and Copper-T-200 was performed simultaneously in Denmark, Finland and Sweden. The results of 741 postmenstrual insertions with Nova-T and 780 with Copper-T are reported. The pregnancy rate of Nova-T was lower in every age and parity group. The pregnancy rate of Copper-T-20...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(79)80004-9
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:Assisting women with choosing contraceptive methods that meet their needs and preferences is essential to providing patient-centered care, but research to inform interventions supporting method choice is lacking. An assessment of patient decisional needs for contraceptive method choice may provide insight int...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.10.004
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Smoking may be related to early discontinuation of oral contraceptives (OC). STUDY DESIGN:This was a planned secondary analysis of a randomized clinical trial. Women aged less than 25 initiating OC at three inner-city publicly funded family planning clinics enrolled in the study. Subjects reported smoking s...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/j.contraception.2008.12.003
更新日期:2009-05-01 00:00:00
abstract::Combination oral contraceptive (COC) users have reduced risks of ovarian and endometrial cancer, but COCs have not reduced breast cancer risk. We have previously argued that a hormonal contraceptive with substantially lower doses of sex-steroids should reduce breast cancer risk by decreasing the breast epithelial cell...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90095-o
更新日期:1993-05-01 00:00:00
abstract::This was a dual-cohort study performed to determine if, by using methotrexate alone, abortions could be induced with fewer side effects, without sacrificing effectiveness and patient satisfaction. The subjects were 358 consecutive patients who requested elective medical termination of pregnancy at < 7 weeks gestation....
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(98)00146-2
更新日期:1999-01-01 00:00:00
abstract::Scarce data are available on the relation between the effectiveness of intrauterine device (IUD) and the gynecologic features of a woman. A nested case-control study was conducted to determine whether the uterine position and hysterometry affect the pregnancy rate of copper IUD. Seventy-one cases (pregnant women with ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00480-8
更新日期:2003-03-01 00:00:00
abstract::This article reports the effects of gossypol at the genomic level in rat spermatogenic cells. After gossypol treatment for various times (8, 12, and 19 weeks), the spermatogonial cells were allowed to rest for 2 to 4 weeks. The function of histone H4 gene promoter (H4GP) in the repopulating pachytene spermatocytes (RP...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(95)00139-5
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVES:The Natural Cycles application is a fertility awareness-based contraceptive method that uses dates of menstruation and basal body temperature to inform couples whether protected intercourse is needed to prevent pregnancies. Our purpose with this study is to investigate the contraceptive efficacy of the mobil...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.08.014
更新日期:2017-12-01 00:00:00
abstract::The pharmacology and clinical assessment of existing first generation once-a-month combined injectable contraceptives, mainly Deladroxate and Chinese Injectable No. 1, are reviewed. Although these two types of monthly injectables have been used in some million women in China and Latin America, Deladroxate needs indept...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(94)90033-7
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Most of the sexually transmitted infection prevention programs fail to attend to the relationship type of individuals at first sexual intercourse and how it influences contraceptive behavior. STUDY DESIGN:A national sample of adolescents (3084 females and 2745 for males) was analyzed to determine the associ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.09.030
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:This prospective observational study evaluated the bleeding patterns of women using a vaginal ring releasing 120 microg of etonogestrel and 15 microg of ethinyl estradiol daily, over a continuous period of 84 days followed by 7 ring-free days. METHODS:The study enrolled 75 volunteers aged 18 to 37 years. ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2006.10.009
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:Combined oral contraceptives (COCs) decrease testosterone (T) levels. This study investigated restoration of T and other androgen concentrations during COC use by 'co-administration' of dehydroepiandrosterone (DHEA). STUDY DESIGN:In this randomized, double-blind, placebo-controlled study in 99 new COC start...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2014.11.002
更新日期:2015-02-01 00:00:00
abstract::Seventy women with prolactinomas, age 19-38 years, were studied in order to evaluate a possible relationship between the use of steroidal oral contraceptives (o.c.) and the development of prolactin-producing adenomas. Sixty-seven patients were admitted for investigation because of menstrual bleeding disturbances and t...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90057-4
更新日期:1983-01-01 00:00:00
abstract::In a cross-over study with orally administered desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) and 3-keto-desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) in ten women under steady-state conditions, the serum levels of 3-keto-desogestrel were monitored by radioimmunoassay. No statistically significant...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90047-8
更新日期:1986-06-01 00:00:00
abstract::A 28-year-old woman presented with a malpositioned intrauterine device (IUD) that was fragmented and significantly entrenched within the cervical canal and myometrium. IUD malposition with concomitant device fragmentation and embedded segments, albeit rare, should be a consideration given the device's prevalence. ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.08.010
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the initial safety and effectiveness of the intrauterine ball (IUB), a copper intrauterine device that, upon insertion in the uterus, takes a three-dimensional spherical form. STUDY DESIGN:Fifteen women were followed for 1 year, with follow-up visits at 1, 3, 6, 9 and 12 months. RESULTS:The phys...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2013.10.017
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Music has served as an auxiliary analgesic in perioperative settings. This study evaluates the impact of intraoperative music added to routine pain control measures during first trimester surgical abortion. STUDY DESIGN:We analyzed data from 101 women randomized to undergo abortion with routine pain control...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2011.11.017
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To identify factors associated with contraceptive uptake among participants in a miscarriage management clinical trial. STUDY DESIGN:We performed a secondary analysis of a multi-center, randomized controlled trial of medical management regimens for miscarriage between 5 and 12 completed weeks. Pregnancy inte...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.03.002
更新日期:2020-06-01 00:00:00
abstract::The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(87)90077-1
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. STUDY DESIGN:We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this c...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.08.016
更新日期:2020-12-01 00:00:00
abstract::Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were measured in seven volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. Blood samples were collected twice weekly during a mean of 93 days immediately postmenstrually and during a mean of 41 days over the twelfth to...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90003-7
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND:New strategies are needed for preventing HIV infection in women. One potential approach is female-initiated use of an effective topical microbicidal gel in combination with a cervical barrier such as the diaphragm. STUDY DESIGN:Randomized, placebo-controlled safety and feasibility trial of diaphragm with va...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2009.10.011
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:A formulation of depot medroxyprogesterone acetate (DMPA) has been developed that allows subcutaneous injection (104 mg/0.65 mL; DMPA-SC) and achieves highly effective contraception with a similar tolerability profile to intramuscular DMPA (150 mg/mL; DMPA-IM). STUDY DESIGN:This randomized, evaluator-blinde...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2009.02.005
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Female sterilization is one of the most prevalent methods of contraception in the United States. Prior studies have shown that nearly half of postpartum tubal ligation (PPTL) requests go unfulfilled. This study seeks to establish whether obstetric or medical risk status influences patients' request for or sub...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2016.08.009
更新日期:2017-03-01 00:00:00
abstract::Separate crossover studies compared the bioavailability of oral vs. vaginal routes of administration for the Yuzpe (n=5) and levonorgestrel regimens (n=4) of emergency contraception. Twice the standard dose of the Yuzpe regimen (200 microg of ethinyl estradiol, 1000 microg of levonorgestrel) or the levonorgestrel regi...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2004.09.009
更新日期:2005-03-01 00:00:00