Abstract：
BACKGROUND:Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. STUDY DESIGN:Six healthy postmenopausal volunteers, not recently using any hormonal therapies, comprise the sample for this study. Each subject was studied on two occasions with multiple blood sampling for assay of NES over a 24-h period: on the first occasion, after a single dosage of 3 x 90 microL NES sprays using a specially devised, precisely metered delivery device; on the second occasion, following the fifth in a series of five daily transdermal dosages of 3 x 90 microL of NES spray. Conventional pharmacokinetic parameters were calculated. NES was assayed in serum using a specific radioimmunoassay. RESULTS:Mean serum levels of NES peaked at around 20 h following dosing, and levels plateaued at 285-290 pmol/L after 4-5 days of daily spray application. All subjects achieved satisfactory serum levels, although substantial intersubject variation was noted. The apparent elimination half-life of NES after the last dose on Day 5 was 26.8 h. No unexpected adverse events were encountered. CONCLUSION:This early pharmacokinetic trial of a new transdermal steroid delivery system has demonstrated the feasibility of achieving serum levels of NES sufficient to block ovulation and potentially provide effective contraception.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Fraser IS,Weisberg E,Kumar N,Kumar S,Humberstone AJ,McCrossin L,Shaw D,Tsong YY,Sitruk-Ware Rdoi
10.1016/j.contraception.2007.08.006subject
Has Abstractpub_date
2007-12-01 00:00:00pages
432-8issue
6eissn
0010-7824issn
1879-0518pii
S0010-7824(07)00409-Xjournal_volume
76pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:New studies linking use of oral contraceptives (OCs) containing a third generation progestogen with venous thromboembolism (VTE) have stirred controversy. Epidemiologists face the task of separating a direct effect of the OC from the confounding effect of a pre-existing factor (e.g., smoking). Only 1-2% of VTE cases...
journal_title：Contraception
pub_type： 评论,社论
doi：10.1016/0010-7824(96)00111-4
更新日期：1996-07-01 00:00:00
abstract：:Emergency contraception promises to reduce Mexico's high unwanted pregnancy and unsafe abortion rates. Because oral contraceptives are sold over-the-counter, several emergency contraceptive regimens are already potentially available to those women who know about the method. Soon, specially packaged emergency contracep...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(99)00088-8
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVE:To examine from the health care services payer perspective the economic consequences of contraceptives available to women in the United States. METHODS:A Markov model was constructed to compare effectiveness and costs among nine contraceptive methods (including 3-month injectable, oral contraceptives, intrau...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(03)00078-7
更新日期：2003-07-01 00:00:00
abstract：:The clinical performance of the Copper T 380A (TCu 380A) and the Lippes Loop intrauterine devices (IUDs) were evaluated for 12 months in a group of 710 women who had one of the two IUDs inserted. Results are from a randomized clinical trial conducted at three collaborating research sites located in three developing co...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0010-7824(95)00119-u
更新日期：1995-07-01 00:00:00
abstract：:Low but rising serum human chorionic gonadotropin (hCG) levels occur infrequently after an induced abortion. Because this scenario rarely occurs after suction aspiration, clinicians may have higher suspicion for an uncommon diagnosis. The differential diagnosis includes both common and uncommon diagnoses, such as inco...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.07.136
更新日期：2018-12-01 00:00:00
abstract：:A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. Restoration of fertility was characterized by a reduction of the litter size resulting from the first inpregnation post-treatment. There was no evidence of tissue pathogenesis 6-12 months after treatment. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90061-x
更新日期：1980-08-01 00:00:00
abstract：PURPOSE:The purpose of this study was to explore the relationship between oral contraceptive pill (OCP) use and the experience of depressive symptoms among a representative sample of young Australian women. METHODS:The study sample comes from the Australian Longitudinal Study on Women's Health. Analysis was confined t...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2006.08.002
更新日期：2007-01-01 00:00:00
abstract：:The effect of 2 long-acting injectables on the plasma protein-bound carbohydrate components and serumucoid when taken for different periods, was illustrated in 100 women of childbearing age. 40 acted as controls, 30 took depot-medroxyprogesterone acetate (DMPA), and 30 took norethisterone enanthate (NET-EN). DMPA wa...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/0010-7824(77)90051-8
更新日期：1977-10-01 00:00:00
abstract：:A review of new Zoapatle publications was made, including five chemical compounds characterized recently. Relative potency of Kaurenoic acid, Kauradienoic acid (its mixture), Zoapatanol and Montanol was estimated in an in vitro guinea pig uterine assay. Kaurene compounds were several times more potent than Montanol an...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(85)90084-8
更新日期：1985-05-01 00:00:00
abstract：:There is a global need for an ideal method of male contraception. However, the development of male contraceptives has not been well successful. Research on sperm-specific ion channels, especially the recent advance obtained from electrophysiological studies, has emphasized the conception that those channels are target...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2013.06.002
更新日期：2013-10-01 00:00:00
abstract：:The effect of cupric ions on the uptake of tritiated-thymidine and 5-tritiated-uridine into endometrial cells obtained from pseudopregnant rabbits was studied in vitro. In endometrial cells obtained 48 and 120 hours after human chorionic gonadotropin injection, the uptake of tritiated-thymidine was significantly inhi...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(75)90076-1
更新日期：1975-10-01 00:00:00
abstract：:Related to concerns about the role of obesity in the efficacy of contraceptive drugs, a review of the literature was carried out in regard to the pharmacokinetics of ethinyl estradiol and various progestins given by various routes of administration. Most studies show that obese women exhibit modestly lower plasma conc...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2016.08.003
更新日期：2017-01-01 00:00:00
abstract：:Partially purified human ovarian follicular fluid peptide (hGF2) was administered during follicular phase in 5 bonnet monkeys. In control as well as hGF2-injected animals, ovulation was synchronized by treatment with FSH, Pergonal and hCG. All the 5 control bonnet monkeys showed plasma estradiol peak followed by incre...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(92)90060-7
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVES:We aimed to qualitatively evaluate factors that contribute to and alleviate grief associated with termination of a pregnancy for a fetal anomaly and how that grief changes over time. STUDY DESIGN:We conducted a longitudinal qualitative study of decision satisfaction, grief and coping among women undergoing ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.11.015
更新日期：2015-03-01 00:00:00
abstract：:A 28-year-old woman presented with a malpositioned intrauterine device (IUD) that was fragmented and significantly entrenched within the cervical canal and myometrium. IUD malposition with concomitant device fragmentation and embedded segments, albeit rare, should be a consideration given the device's prevalence. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.08.010
更新日期：2019-01-01 00:00:00
abstract：:Because RU 486 synergizes with anordrin and its dihydroxylated metabolite to terminate established pregnancy in the rat and rabbit, the interactions of these agents were studied at two days postcoitally in the rat. RU 486 at a dose of 4 mg/kg did not prevent pregnancy when the animals were killed 12 days post insemina...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(93)90038-9
更新日期：1993-04-01 00:00:00
abstract：OBJECTIVE:To understand effect of adjunct misoprostol on cervical preparation with overnight osmotic dilators for dilation and evacuation after 16 weeks gestation. METHODS:We searched on-line reference databases using search terms for second trimester, abortion, misoprostol, and dilators. Randomized controlled trials ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.09.005
更新日期：2020-02-01 00:00:00
abstract：:User satisfaction and the physical and psychological effects of five commonly used contraceptive methods were investigated in a population survey among 1466 West German women. The focus was on effects attributed by current and past users to these methods, rather than objectively assessed effects, to shed further light...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(99)00034-7
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVES:To report length of intrauterine device (IUD) and strings as well as technique for extraction when IUD removal occurs without visible strings. STUDY DESIGN:A prospective case series of 29 women who had IUDs removed in-office when strings were not visible at the external cervical os. RESULTS:One third (n=11...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.04.007
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To describe the efficacy, safety, and acceptability of medical abortion in the late first trimester. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of medical abortion at gestational ages (>63 to≤84 days gestation). We sought articles that compar...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.11.002
更新日期：2019-02-01 00:00:00
abstract：:Condoms from five manufacturers were subjected to controlled exposures of heat, humidity, and air and to different natural environments in five countries. Under aerobic conditions (condoms in permeable packages or unpackaged), stress properties declined. The relationship between rate of decline as a function of temper...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(96)00041-8
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVES:To assess factors associated with pregnancy fatalism among U.S. adult women. STUDY DESIGN:I used data from the Change and Consistency in Contraceptive Use study, which collected information from a national sample of 4634 U.S. women aged 18-39 at baseline (59% response rate). I assessed pregnancy fatalism ba...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.05.015
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:As part of a strategy to revitalize postpartum family planning services, Government of India revised its policy in 2013 to permit trained nurses and midwives to insert postpartum intrauterine contraceptive devices (PPIUCDs). This study compares two key outcomes of PPIUCD insertions--expulsion and infection--f...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.12.012
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:To compare time from misoprostol initiation to fetal expulsion for mifepristone-misoprostol versus misoprostol-alone regimens of medication abortion performed at ≥24 weeks' gestation. STUDY DESIGN:We conducted a retrospective study of medication abortion performed at ≥24 weeks' gestation between May 2016 and...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.05.001
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Obesity is becoming increasingly common in obstetric and gynecologic populations, which may affect the safety of surgical termination of pregnancy. STUDY DESIGN:We performed a retrospective review of all patients undergoing second-trimester surgical termination of pregnancy by under ultrasound guidance term...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2012.02.006
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Patient characteristics associated with adherence to dual-method contraceptive use are not known. STUDY DESIGN:Project PROTECT was a 24-month-long randomized trial designed to promote the use of dual methods of contraception using an individualized computer-based intervention or enhanced standard care couns...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2011.01.023
更新日期：2011-09-01 00:00:00
abstract：:Twenty normotensive and ten hypertensive black women taking oral contraceptive (OC) were studied. Age, body weight, family medical history of hypertension, length of OC use, and type of OC were comparable. At midcycle approximately 10-12 hours following OC intake, blood was drawn and the plasma was used to determine e...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(81)80006-6
更新日期：1981-06-01 00:00:00
abstract：OBJECTIVE:Evaluating decisional certainty is an important component of medical care, including preabortion care. However, minimal research has examined how to measure certainty with reliability and validity among women seeking abortion. We examine whether the Decisional Conflict Scale (DCS), a measure widely used in ot...
journal_title：Contraception
pub_type： 杂志文章,多中心研究
doi：10.1016/j.contraception.2016.09.008
更新日期：2017-03-01 00:00:00
abstract：:Neo Sampoon is an effervescent contraceptive vaginal tablet manufactured in Japan that contains 60 mg of the spermicide menfegol. Ortho Vaginal Tablets (OVT) and Emko Vaginal Tablets (EVT), both containing 100 mg of the spermicide nonoxynol-9, were manufactured in the USA. The three products were compared in a randomi...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(85)90015-0
更新日期：1985-11-01 00:00:00
abstract：:The clinical performance of two levonorgestrel-releasing intrauterine devices (IUDs) with different release rates was studied and compared with a copper-releasing Nova-T device in a randomized partly double-blind multiclinical trial. Special attention was given to patterns of bleeding, hormonal side-effects, blood pre...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(82)90092-0
更新日期：1982-04-01 00:00:00
