Clarification of contraceptive drug pharmacokinetics in obesity.

abstract：BACKGROUND:This retrospective analysis evaluated the association of age and weight with cycle control in women using either of two formulations of low-estrogen-dose oral contraceptives. STUDY DESIGN:Data for this secondary analysis were derived from a randomized multicenter trial assessing the efficacy and safety of n...

journal_title：Contraception

authors： Hampton RM,Zhang HF,Barnowski C,Wan GJ

更新日期：2008-06-01 00:00:00

abstract：CONTEXT:Progestins delivered by a variety of routes have been demonstrated, in addition to their high contraceptive effect, to have substantial benefits in the treatment of various gynecological disorders, and the intrauterine route has particular efficacy in treating endometrial and myometrial disorders. It should be ...

journal_title：Contraception

authors： Fraser IS

更新日期：2007-06-01 00:00:00

abstract：:The comparative in vitro spermicidal effects of (+)-gossypol, (-)-gossypol and (+/-)-gossypol were evaluated on the spermatozoa of human, monkey, rabbit, mouse, rat and hamster. The spermicidal effects of gossypol isomers were also compared with those of gossypolone, which is a proposed major metabolite of gossypol. G...

journal_title：Contraception

authors： Kim IC,Waller DP,Marcelle GB,Cordell GA,Fong HH,Pirkle WH,Pilla L,Matlin SA

更新日期：1984-09-01 00:00:00

abstract：:Ovarian function, bleeding patterns and serum lipoproteins were studied in women using contraceptive vaginal rings (CVRs) of dimethyl-polysiloxane impregnated with steroids. The different CVRs were used for about 10 cycles each. The following groups were studied, with the daily steroid dosage given in parentheses. Wom...

journal_title：Contraception

authors： Ahrén T,Victor A,Lithell H,Vessby B,Jackanicz TM,Johansson ED

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to provide evidence about the mechanism of action of the Yuzpe method of emergency contraception by examining effectiveness by cycle day of intercourse relative to ovulation. METHODS:Through a literature search, we identified eight studies that present the number of women treate...

journal_title：Contraception

authors： Trussell J,Ellertson C,Dorflinger L

更新日期：2003-03-01 00:00:00

abstract：:As part of a 60-week, open-label, nonrandomized, parallel, controlled study comparing a monthly contraceptive injection containing medroxyprogesterone acetate (MPA) 25 mg and estradiol cypionate (E(2)C) 5 mg (Lunelle Monthly Contraceptive Injection) and a norethindrone 0.5, 0.75, 1.0 mg/0.035 mg ethinyl estradiol (NET...

journal_title：Contraception

authors： Cromie MA,Maile MH,Wajszczuk CP

更新日期：2000-01-01 00:00:00

abstract：:This review provides an update of previous estimates of first-year probabilities of contraceptive failure for all methods of contraception available in the United States. Estimates are provided of probabilities of failure during typical use (which includes both incorrect and inconsistent use) and during perfect use (c...

journal_title：Contraception

authors： Trussell J

更新日期：2011-05-01 00:00:00

abstract：:To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed ...

journal_title：Contraception

authors： Laufe LE,Sokal DC,Cole LP,Shoupe D,Schenken RS

更新日期：1996-09-01 00:00:00

abstract：:Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed ...

journal_title：Contraception

authors： Back DJ,Breckenridge AM,Chapman CR,Crawford FE,Olsen KA,Orme ML,Rowe PH

更新日期：1981-02-01 00:00:00

abstract：:The changes in haemostasis during oral contraception are related to the ethinylestradiol dose present in the formulation taken by the patient. An open, randomized longitudinal study was performed to evaluate and compare the effects that low-dose oral contraceptives (OCs) containing different doses of ethinylestradiol ...

journal_title：Contraception

authors： Melis GB,Fruzzetti F,Nicoletti I,Ricci C,Lammers P,Atsma WJ,Fioretti P

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Women with cardiac disease have need for effective long-lasting reversible contraception. Women with cardiac disease are at increased risk for bacterial endocarditis. There is limited research regarding the use of intrauterine contraceptive devices (IUD) in women with cardiac disease. STUDY DESIGN:In a pros...

journal_title：Contraception

authors： Suri V,Aggarwal N,Kaur R,Chaudhary N,Ray P,Grover A

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate long-term safety of quinacrine pellets for nonsurgical sterilization among women in Vietnam. STUDY DESIGN:Observational cohort study of 2735 women who had quinacrine insertions between 1989 and 1993 compared to 1623 women who received an intrauterine device (IUD). RESUL...

journal_title：Contraception

authors： Sokal DC,Hieu do T,Loan ND,Hubacher D,Nanda K,Weiner DH,Vach TH

更新日期：2008-07-01 00:00:00

abstract：:The effect of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro-5-triazole (5,1a)-isoquinoline, a non-hormonal post-implantational anti-fertility drug, on tissue weights, nucleic acids and total protein concentrations in the testes, ventral prostate and seminal vesicles were evaluated in immature and sexually mature rats, while ...

journal_title：Contraception

authors： Prasad RS,Vijayan E

更新日期：1987-11-01 00:00:00

abstract：:In order to determine whether inhibition of the endometrial estradiol-17 beta-dehydrogenase activity by Cu++ could be one of the factors accounting for the enhanced contraceptive efficacy of copper intrauterine devices (Cu-IUD), the activity of the enzyme was measured in endometrial biopsies from women wearing this de...

journal_title：Contraception

authors： Tseng L,Dramusic V,Gurpide E

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND:Weight gain is commonly reported as a side effect of hormonal contraception and can lead to method discontinuation or reluctance to initiate the method. The purpose of this study was to investigate weight change in adolescent (aged 15-19 years) users of depot-medroxyprogesterone acetate (DMPA), norethisteron...

journal_title：Contraception

authors： Beksinska ME,Smit JA,Kleinschmidt I,Milford C,Farley TM

更新日期：2010-01-01 00:00:00

abstract：:A randomised cross-over trial was performed to compare the pharmacodynamic actions of three low-dose oral contraceptives (OCs): Marvelon (150 micrograms desogestrel (DSG)+ 30 micrograms ethinyloestradiol (EE)), Mercilon (150 micrograms DSG + 20 micrograms EE) and Microgynon (150 micrograms levonorgestrel (LNG) + 30 mi...

journal_title：Contraception

authors： Song S,Chen JK,Yang PJ,He ML,Li LM,Fan BC,Rekers H,Fotherby K

更新日期：1992-06-01 00:00:00

abstract：:First year results of a randomized study of 1509 users of the Copper T380Ag with a silver core or of an IUD releasing 20 mcg day of levonorgestrel are reported. The cumulative gross pregnancy rate for each device was 0.3 per 100 at one year, with more than 490 women having one year of use with each device. The levonor...

journal_title：Contraception

authors： Sivin I,Alvarez F,Diaz J,Diaz S,el Mahgoub S,Coutinho E,Brache V,Diaz MM,Faundes A,Pavez M

更新日期：1984-11-01 00:00:00

abstract：:A group of 120 women with gestations from 64 to 84 days received 800 micrograms of vaginal misoprostol every 24 h for a maximum of three doses without performing postexpulsion systematic preventive curettage. Outcome measures included successful abortion (complete abortion without requiring a surgical procedure), side...

journal_title：Contraception

authors： Carbonell Esteve JL,Varela L,Velazco A,Cabezas E,Tanda R,Sánchez C

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations. STUDY DESIGN:We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definiti...

journal_title：Contraception

authors： Heinemann K,Barnett C,Reed S,Möhner S,Do Minh T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether women might be interested in repeated use of a pericoital pill, a pill taken around the time of each act of intercourse. STUDY DESIGN:We surveyed women from abortion (n=635) and family planning (n=981) clinics regarding their interest in using a pericoital ...

journal_title：Contraception

authors： Foster DG,Biggs MA,Grossman D,Schwarz EB

更新日期：2013-07-01 00:00:00

abstract：:Patterns of bleeding and plasma concentrations of levonorgestrel, progesterone, estradiol, LH and FSH were studied in ten volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. The IUD was designed to release 12 microgram/day. All but two of the volunteers ovulated during treatment. The ovulatory ...

journal_title：Contraception

authors： Nilsson CG,Lähteenmäki P,Luukkainen T

更新日期：1980-02-01 00:00:00

abstract：:Twenty patients undergoing elective midtrimester abortion by urea amnioinfusion had bacteriologic culture data obtained before and after the procedure. Despite the presence of pathogens in the vagina and cervix prior to the procedure, only 20% of patients exhibited endometrial growth following abortion. Factors that s...

journal_title：Contraception

authors： Burkman RT,Spence MR,Atienza MF,King TM

更新日期：1978-06-01 00:00:00

abstract：:The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected...

journal_title：Contraception

authors： Takkar D,Jeyaseelan S,Kinra G,Laumas KR,Hingorani V

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:A formulation of depot medroxyprogesterone acetate (DMPA) has been developed that allows subcutaneous injection (104 mg/0.65 mL; DMPA-SC) and achieves highly effective contraception with a similar tolerability profile to intramuscular DMPA (150 mg/mL; DMPA-IM). STUDY DESIGN:This randomized, evaluator-blinde...

journal_title：Contraception

authors： Kaunitz AM,Darney PD,Ross D,Wolter KD,Speroff L

更新日期：2009-07-01 00:00:00

abstract：:A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using the levonorgestrel subdermal implants NORPLANT for contraceptive purposes. At the end of 1 year of use, results from this on-going study indicate that these subjects may have an increased predisposition to thrombosis as e...

journal_title：Contraception

authors： Viegas OA,Singh K,Koh S,Singh P,Ratnam SS

更新日期：1988-09-01 00:00:00

abstract：:The objectives of the study were to assess the ability of the Femcap, a new vaginal contraceptive device made of silicone and designed to fit snugly around the cervix to prevent the penetration of sperm into midcycle cervical mucus when used with and without spermicide; and to compare it with the standard contraceptiv...

journal_title：Contraception

authors： Mauck CK,Baker JM,Barr SP,Johanson W,Archer DF

更新日期：1997-08-01 00:00:00

abstract：:This prospective, open-label, randomized trial of healthy adult women up to 9 weeks pregnant compared mifepristone 200 mg followed 2 days later with misoprostol 400 microg orally versus misoprostol 800 microg vaginally. The study was interrupted after the oral misoprostol group experienced a higher than expected failu...

journal_title：Contraception

authors： Schaff EA,Fielding SL,Westhoff C

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Higher rates of unwanted pregnancies and lower rates of contraceptive use have been reported among Hispanic women than among non-Hispanic whites. Despite these differences, it is unclear how these groups differ with respect to various psychosocial factors that are associated with contraceptive decision makin...

journal_title：Contraception

authors： Sangi-Haghpeykar H,Ali N,Posner S,Poindexter AN

更新日期：2006-08-01 00:00:00

abstract：:Intrauterine devices releasing 20 micrograms/day levonorgestrel were inserted in 10 women (ages 25-34). Bleeding and spotting patterns were recorded on a menstrual card during one year of follow-up. Blood samples were collected for radioimmunoassays of LH, estradiol (E2), progesterone (P) and levonorgestrel (LNG) and ...

journal_title：Contraception

authors： Xiao BL,Zhou LY,Zhang XL,Jia MC,Luukkainen T,Allonen H

更新日期：1990-04-01 00:00:00

abstract：:Saponins isolated from Sapindus mukorossi have potent spermicidal activity. Morphological changes in human ejaculated spermatozoa after exposure to these saponins were evaluated under Scanning Electron Microscope. The minimum effective concentration (0.05% in spot test) did not affect the surface topography after expo...

journal_title：Contraception

authors： Dhar JD,Bajpai VK,Setty BS,Kamboj VP

更新日期：1989-05-01 00:00:00