Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone.

Abstract:

:The comparative in vitro spermicidal effects of (+)-gossypol, (-)-gossypol and (+/-)-gossypol were evaluated on the spermatozoa of human, monkey, rabbit, mouse, rat and hamster. The spermicidal effects of gossypol isomers were also compared with those of gossypolone, which is a proposed major metabolite of gossypol. Gossypol isomers and gossypolone were all spermicidal. (+)- and (-)-Gossypol demonstrated spermicidal activities at the same concentration at which (+/-)-gossypol shows spermicidal effects on the spermatozoa of all species tested. However, gossypolone was less potent than the gossypol isomers. The spermicidal action of gossypol may be a nonspecific effect unrelated to the antifertility mechanism of orally administered gossypol, since (+)-gossypol which is not an effective male antifertility agent also showed the equivalent spermicidal effect to that of (+/-)-gossypol.

journal_name

Contraception

journal_title

Contraception

authors

Kim IC,Waller DP,Marcelle GB,Cordell GA,Fong HH,Pirkle WH,Pilla L,Matlin SA

doi

10.1016/0010-7824(84)90088-x

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

253-9

issue

3

eissn

0010-7824

issn

1879-0518

pii

0010-7824(84)90088-X

journal_volume

30

pub_type

杂志文章
  • Cervical preparation for second-trimester surgical abortion prior to 20 weeks' gestation: SFP Guideline #2013-4.

    abstract::For a dilation and evacuation (D&E) procedure, the cervix must be dilated sufficiently to allow passage of operative instruments and products of conception without injuring the uterus or cervical canal. Preoperative preparation of the cervix reduces the risk of cervical laceration and uterine perforation. The cervix m...

    journal_title:Contraception

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.contraception.2013.11.001

    authors: Fox MC,Krajewski CM

    更新日期:2014-02-01 00:00:00

  • Women's knowledge of their state's abortion regulations. A national survey.

    abstract:OBJECTIVES:States vary significantly in their regulation of abortion. Misinformation about abortion is pervasive and propagated by state-mandated scripts that contain abortion myths. We sought to investigate women's knowledge of abortion laws in their state. Our secondary objective was to describe women's ability to di...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.08.001

    authors: Swartz JJ,Rowe C,Morse JE,Bryant AG,Stuart GS

    更新日期:2020-11-01 00:00:00

  • A single-blinded randomized controlled trial evaluating pain and opioid use after dilator placement for second-trimester abortion.

    abstract:OBJECTIVES:To compare pain levels and medication needs after placement of laminaria vs Dilapan-S, and after dilation and evacuation (D&E). STUDY DESIGN:We conducted a single-blinded randomized control trial of patients undergoing D&E at 15 0/7 to 23 6/7 weeks gestation, randomizing to cervical preparation with laminar...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.11.014

    authors: Liu SM,Flink-Bochacki R

    更新日期:2020-12-04 00:00:00

  • Bleeding patterns of adolescents using a combination contraceptive injection for 1 year.

    abstract:PURPOSE:This prospective observational study evaluated the bleeding patterns of adolescents receiving a monthly injectable contraceptive containing norethisterone enanthate 50 mg plus estradiol valerate 5 mg. MATERIALS AND METHODS:The study enrolled 73 volunteers aged between 14 and 19 years; of these patients, 38 (52...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2006.01.009

    authors: Bortolotti de Mello Jacobucci MS,Guazzelli CA,Barbieri M,Araújo FF,Moron AF

    更新日期:2006-06-01 00:00:00

  • Determinants of oral contraceptive use in northern Italy.

    abstract::Socio-demographic characteristics, general lifestyle habits, reproductive and medical histories were compared of 328 women who had ever used oral contraceptives and 2306 never users from a case-control surveillance conducted in Northern Italy. Oral contraceptive use was positively and strongly related with the level o...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(86)90067-3

    authors: La Vecchia C,Decarli A,Parazzini F,Gentile A,Negri E,Franceschi S

    更新日期:1986-08-01 00:00:00

  • Prospective randomized, controlled study of postoperative pain after titanium silicone rubber clip or Silastic ring tubal occlusion.

    abstract:OBJECTIVE:To determine if laparoscopic sterilization using the Filshie clip causes less postoperative pain as compared to the Falope ring during the first 24 h after surgery. STUDY DESIGN:Forty subjects were enrolled. Five milliliters of 0.5% bupivicaine was injected at each of the two incision sites and 5 mL was drip...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.contraception.2003.09.014

    authors: Pymar HC,Creinin MD,Vallejo MC

    更新日期:2004-02-01 00:00:00

  • A comparative study of a progestin-only oral contraceptive versus non-hormonal methods in lactating women in Buenos Aires, Argentina.

    abstract::A non-randomized comparative clinical trial of the progestin-only oral contraceptive (POC), Ovrette (75 mcg norgestrel) (Wyeth), versus non-hormonal methods was conducted at two clinics in Buenos Aires, Argentina. The trial was designed to assess the breast-feeding patterns of women choosing progestin-only oral contra...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(91)90104-n

    authors: Moggia AV,Harris GS,Dunson TR,Diaz R,Moggia MS,Ferrer MA,McMullen SL

    更新日期:1991-07-01 00:00:00

  • Adolescent contraceptive use and its determinants in Bangladesh: evidence from Bangladesh Fertility Survey 1989.

    abstract::This study is concerned with contraceptive use among the currently married adolescents in Bangladesh utilizing the 1989 Bangladesh Fertility Survey (BFS) data. The study analyzes the factors affecting the current use of contraception among the adolescents through bivariate and multivariate logistic regression analysis...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(95)00149-5

    authors: Mahmud M,Islam MM

    更新日期:1995-09-01 00:00:00

  • Inhibition of luteal phase progesterone levels in the rhesus monkey by epostane.

    abstract::This study examined the effect of epostane, a new antifertility drug, on normal and hCG-stimulated progesterone production during the luteal phase of the menstrual cycle in rhesus monkeys. When administered once each day for five days, epostane inhibited normal luteal phase progesterone levels in a dose-related fashio...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(85)90083-6

    authors: Snyder BW,Schane HP

    更新日期:1985-05-01 00:00:00

  • Menstrual patterns and progesterone circulating levels following different procedures of tubal occlusion.

    abstract::This study was undertaken to assess the effects of different tubal occlusion procedures on ovarian function. Three groups of subjects randomized to tubal occlusion by laparoscopy and Yoon ring (24 subjects), minilaparotomy and Yoon ring (19 subjects) and minilaparotomy and Pomeroy (22 subjects), and one separate contr...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(89)90003-6

    authors: Rivera R,Gaitan JR,Ruiz R,Hurley DP,Arenas M,Flores C,Hernandez AB

    更新日期:1989-08-01 00:00:00

  • Contraceptive use at last intercourse among reproductive-aged women with disabilities: an analysis of population-based data from seven states.

    abstract:OBJECTIVE:To assess patterns of contraceptive use at last intercourse among women with physical or cognitive disabilities compared to women without disabilities. STUDY DESIGN:We analyzed responses to 12 reproductive health questions added by seven states to their 2013 Behavioral Risk Factor Surveillance System questio...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.12.008

    authors: Haynes RM,Boulet SL,Fox MH,Carroll DD,Courtney-Long E,Warner L

    更新日期:2018-06-01 00:00:00

  • In vivo measurements of uterine cavities in 795 women of fertile age.

    abstract::The uterine sound length, the functional length of the cervix including the zone of internal cervical os and the fundus transversal were determined in 795 fertile women in vivo using a measuring device, the Cavimeter. The functional cavity length was calculated by subtracting the functional length of the cervix from t...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(84)80011-6

    authors: Kurz KH,Tadesse E,Haspels AA

    更新日期:1984-06-01 00:00:00

  • Comparative effects of Lunelle monthly contraceptive injection (medroxyprogesterone acetate and estradiol cypionate injectable suspension) and ortho-Novum 7/7/7 oral contraceptive (norethindrone/ethinyl estradiol triphasic) on lipid profiles. Investigator

    abstract::As part of a 60-week, open-label, nonrandomized, parallel, controlled study comparing a monthly contraceptive injection containing medroxyprogesterone acetate (MPA) 25 mg and estradiol cypionate (E(2)C) 5 mg (Lunelle Monthly Contraceptive Injection) and a norethindrone 0.5, 0.75, 1.0 mg/0.035 mg ethinyl estradiol (NET...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(99)00114-6

    authors: Cromie MA,Maile MH,Wajszczuk CP

    更新日期:2000-01-01 00:00:00

  • Long-term use of depot-norethisterone enanthate: effect on blood coagulation factors and menstrual bleeding patterns.

    abstract::Fifty-six women using depot-norethisterone enanthate injections for contraception for 2 years or more were compared with a control group of 48 women not using hormonal contraception. No significant difference was found between the study group and controls for Factors VIIc and Antithrombin III. Factor Xc was reduced in...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(91)90083-r

    authors: McEwan JA,Griffin M

    更新日期:1991-12-01 00:00:00

  • Emetine ditartrate: a possible lead for emergency contraception.

    abstract::Interception of pregnancy in its initial stage is an attractive and viable approach to contraception. A chemical agent, taken within the first few days of missed menses, intercepts the conception, which is expelled with menstrual flow. The main targets of such agents are the uterus, blastocyst and the growing trophobl...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2003.12.011

    authors: Mehrotra PK,Kitchlu S,Dwivedi A,Agnihotri PK,Srivastava S,Roy R,Bhaduri AP

    更新日期:2004-05-01 00:00:00

  • Toxicology of polymers for implant contraceptives for women.

    abstract::This article reviews the toxicology of polymers that are used in contraceptive implants. The two main classes of synthetic, nondegradable polymers used in the delivery of female contraceptives are silicone elastomers (e.g., Silastic) and ethylene co-vinyl acetate (EVA; ELVAX). The controversies surrounding the silicon...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/s0010-7824(01)00285-2

    authors: Shastri PV

    更新日期:2002-01-01 00:00:00

  • Choice of the levonorgestrel intrauterine device, etonogestrel implant or depot medroxyprogesterone acetate for contraception after aspiration abortion.

    abstract:OBJECTIVE:Women who have abortions are at high risk of contraception discontinuation and subsequent unintended pregnancy. The objective of this analysis was to identify factors associated with choice of highly effective, long-acting, progestin-only contraceptive methods after abortion. STUDY DESIGN:Women presenting fo...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.06.013

    authors: Steinauer JE,Upadhyay UD,Sokoloff A,Harper CC,Diedrich JT,Drey EA

    更新日期:2015-12-01 00:00:00

  • Progestin-only pill use and pill switching during breastfeeding.

    abstract::The opinions of 20 international experts in reproductive endocrinology and family planning service delivery were solicited concerning contraceptive pill use during breastfeeding and, in particular, to determine whether the experts felt that breastfeeding women who use progestin-only pills (POPs) should be advised to s...

    journal_title:Contraception

    pub_type: 社论

    doi:10.1016/0010-7824(95)00076-m

    authors: Visness CM,Rivera R

    更新日期:1995-05-01 00:00:00

  • STS 557, a new orally active progestin with antiprogestational and contragestational properties in rabbits.

    abstract::STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone ad...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90140-7

    authors: Oettel M,Kurischko A

    更新日期:1980-01-01 00:00:00

  • A comparison of tamoxifen and misoprostol to misoprostol alone for early pregnancy termination.

    abstract::A study was undertaken to determine whether the combination of oral tamoxifen and moistened misoprostol administered vaginally was superior to that of placebo and moistened misoprostol administered vaginally for elective termination of early pregnancies.A clinical trial was conducted with a study group of 150 healthy ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(99)00105-5

    authors: Jain JK,Meckstroth KR,Park M,Mishell DR Jr

    更新日期:1999-12-01 00:00:00

  • Economic analysis of contraceptives for women.

    abstract:OBJECTIVE:To examine from the health care services payer perspective the economic consequences of contraceptives available to women in the United States. METHODS:A Markov model was constructed to compare effectiveness and costs among nine contraceptive methods (including 3-month injectable, oral contraceptives, intrau...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(03)00078-7

    authors: Chiou CF,Trussell J,Reyes E,Knight K,Wallace J,Udani J,Oda K,Borenstein J

    更新日期:2003-07-01 00:00:00

  • A 4-year follow-up study of women with Norplant-2 contraceptive implants.

    abstract::One-hundred-thirty of 178 women who received Norplant-2 implants were followed prospectively for 4 years. Menstrual disorders were the most common reason for discontinuation. Only one patient conceived, for a failure rate of 0.6%. ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00265-7

    authors: Qin LH,Goldberg JM,Hao G

    更新日期:2001-11-01 00:00:00

  • Efficacy and acceptability of testosterone implants, alone or in combination with a 5alpha-reductase inhibitor, for male hormonal contraception.

    abstract::Testosterone (T) treatment suppresses serum gonadotropins and reduces sperm output sufficiently for contraceptive efficacy in approximately 70% of Caucasian men. In the remaining 30% of men, an increase in 5alpha-reductase activity may maintain testicular androgen activity, thus accounting for the failure of sperm sup...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(00)00139-6

    authors: McLachlan RI,McDonald J,Rushford D,Robertson DM,Garrett C,Baker HW

    更新日期:2000-08-01 00:00:00

  • The probability of side effects with ovral, norinyl 1/50 and norlestrin.

    abstract::This report provides specific information on the prevalence rates of the most common side effects during the first 3 cycles of use of 3 combination oral contraceptives (OCs) containing 50 mcg estrogen. The probabilities of a symptom occurring for the first time, or persisting once present, during the initial cycles of...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(79)90050-7

    authors: Berger GS,Edelman DA,Talwar PP

    更新日期:1979-11-01 00:00:00

  • Menstrual blood loss estimates in women using copper 7 and multiload-250 intrauterine devices.

    abstract::An estimate of the menstrual blood loss (MBL) in 29 women using the Cu-7 and in 33 women using the ML-250 IUDs was carried out. None of the women who took part in the study used hormonal contraceptives or IUDs for six months previous to the study. Before the insertion of the IUD, the MBL of each woman was measured for...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(82)90146-9

    authors: Pedrón N,Gallegos AJ,Lozano M,Aznar R

    更新日期:1982-11-01 00:00:00

  • Endometrial histology and progesterone levels in women using norethindrone acetate implants for contraception.

    abstract::The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(78)90066-5

    authors: Takkar D,Jeyaseelan S,Kinra G,Laumas KR,Hingorani V

    更新日期:1978-02-01 00:00:00

  • Randomized comparison of two Internet-supported fertility-awareness-based methods of family planning.

    abstract:BACKGROUND:The aim was to compare the efficacy and acceptability of two Internet-supported fertility-awareness-based methods of family planning. STUDY DESIGN:Six hundred and sixty-seven women and their male partners were randomized into either an electronic hormonal fertility monitor (EHFM) group or a cervical mucus m...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2012.10.010

    authors: Fehring RJ,Schneider M,Raviele K,Rodriguez D,Pruszynski J

    更新日期:2013-07-01 00:00:00

  • The effect of nitroglycerin on the IUD insertion experience in nulliparous women: a pilot study.

    abstract:OBJECTIVE:Concern about pain during placement of an intrauterine device (IUD) represents a barrier to use, especially among nulliparous women. We hypothesized that nitroglycerin gel applied vaginally 30 min prior to IUD placement would reduce insertion-related pain. STUDY DESIGN:We designed a randomized, double-blinde...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2014.03.012

    authors: Micks EA,Jensen JT,Bednarek PH

    更新日期:2014-07-01 00:00:00

  • Recent intrauterine device use and the risk of precancerous cervical lesions and cervical cancer.

    abstract:OBJECTIVE:Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.04.008

    authors: Averbach S,Silverberg MJ,Leyden W,Smith-McCune K,Raine-Bennett T,Sawaya GF

    更新日期:2018-04-17 00:00:00

  • Comparison of surface morphology and composition of intrauterine devices in relation to patient complaints.

    abstract::The morphology and the related composition of T-type intrauterine devices (IUDs) made of gold-plated copper were studied in relation to patient complaints. The removed IUDs were examined without pretreatment by scanning electron microscopy and energy dispersive x-ray spectroscopy. Besides the previously found incrusta...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2004.03.006

    authors: Patai K,Dévényi L,Zelkó R

    更新日期:2004-08-01 00:00:00