Abstract:
:The comparative in vitro spermicidal effects of (+)-gossypol, (-)-gossypol and (+/-)-gossypol were evaluated on the spermatozoa of human, monkey, rabbit, mouse, rat and hamster. The spermicidal effects of gossypol isomers were also compared with those of gossypolone, which is a proposed major metabolite of gossypol. Gossypol isomers and gossypolone were all spermicidal. (+)- and (-)-Gossypol demonstrated spermicidal activities at the same concentration at which (+/-)-gossypol shows spermicidal effects on the spermatozoa of all species tested. However, gossypolone was less potent than the gossypol isomers. The spermicidal action of gossypol may be a nonspecific effect unrelated to the antifertility mechanism of orally administered gossypol, since (+)-gossypol which is not an effective male antifertility agent also showed the equivalent spermicidal effect to that of (+/-)-gossypol.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Kim IC,Waller DP,Marcelle GB,Cordell GA,Fong HH,Pirkle WH,Pilla L,Matlin SAdoi
10.1016/0010-7824(84)90088-xsubject
Has Abstractpub_date
1984-09-01 00:00:00pages
253-9issue
3eissn
0010-7824issn
1879-0518pii
0010-7824(84)90088-Xjournal_volume
30pub_type
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