Abstract:
:Ovarian function, bleeding patterns and serum lipoproteins were studied in women using contraceptive vaginal rings (CVRs) of dimethyl-polysiloxane impregnated with steroids. The different CVRs were used for about 10 cycles each. The following groups were studied, with the daily steroid dosage given in parentheses. Women using CVRs delivering levonorgestrel (290 micrograms), norethisterone (850 micrograms), medroxyprogesterone acetate (700 micrograms) or megestrol acetate (1.9 mg), all of which were in combination with estradiol (200 ug). Women using CVRs delivering progesterone (5.2 mg). Women taking megestrol acetate orally (15 mg/day) for three weeks. In all women except those using the levonorgestrel CVR, there were indications of incomplete suppression of ovarian activity as shown by elevated levels of progesterone and/or estradiol peaks. Bleeding control seemed to be good with the levonorgestrel CVR and rather poor with the others. Levonorgestrel treatment was associated with a decrease in high density lipoprotein cholesterol (32%) and triglycerides (25%) and a 16% decrease in apolipoprotein A-I. Norethisterone induced a 10% decrease in A-I and a reduction of cholesterol in very low density lipoprotein. All other lipid and apolipoprotein B, A-I and A-II values were unaltered with the administration of the CVRs and with oral megestrol acetate. Levonorgestrel was given in a higher dose than the other progestins, but the absence of effects of the high oral dose of megestrol acetate on the serum lipoproteins indicates that the progesterone-derived progestins in adequate doses probably would not alter the lipoprotein metabolism. Higher doses of progestins are needed to achieve acceptable control of ovarian activity and bleeding patterns than seen with these CVRs.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Ahrén T,Victor A,Lithell H,Vessby B,Jackanicz TM,Johansson EDdoi
10.1016/0010-7824(83)90033-1subject
Has Abstractpub_date
1983-10-01 00:00:00pages
315-27issue
4eissn
0010-7824issn
1879-0518pii
0010-7824(83)90033-1journal_volume
28pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract::Fifty-six women using depot-norethisterone enanthate injections for contraception for 2 years or more were compared with a control group of 48 women not using hormonal contraception. No significant difference was found between the study group and controls for Factors VIIc and Antithrombin III. Factor Xc was reduced in...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(91)90083-r
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVES:We examine the lifetime and past-year prevalence and circumstances of unprotected intercourse among members of the Society of Family Planning (SFP), a professional reproductive health organization in the United States. STUDY DESIGN:We invited the membership of SFP (n=477) via email to participate in an anon...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.04.004
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. STUDY DESIGN:This study evaluated in v...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.08.014
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The aim of this study is to explore the effect of first-trimester mifepristone-induced abortion on vaginal bleeding in subsequent pregnancy. STUDY DESIGN:This observational cohort study was conducted during 1998-2001 at antenatal clinics in Beijing, Chengdu, and Shanghai, China. The study enrolled 4,931 wom...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2011.03.013
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To describe clinical outcomes of etonogestrel implant patients with migration to the vasculature, chest wall and other distant body sites spontaneously reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. STUDY DESIGN:We performed a standardized Medical Dictionary ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.08.009
更新日期:2017-12-01 00:00:00
abstract::The relationship of depot-medroxyprogesterone acetate (D-MPA) use to risk of cervical carcinoma in situ was investigated using data from a large multi-national, hospital-based case-control study. To avoid possible detection bias from Pap smear screening, final analyses were restricted to a subset of cases with symptom...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/0010-7824(94)00007-j
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Developing an objective, reliable method to determine semen exposure in cervicovaginal fluids is important for accurately studying the efficacy of vaginal microbicides and contraceptives. Y-chromosome biomarkers offer better stability, sensitivity, and specificity than protein biomarkers. TSPY4 belongs to th...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.11.022
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. STUDY DESIGN:Six healthy postmenopausal volun...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2007.08.006
更新日期:2007-12-01 00:00:00
abstract::Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90098-6
更新日期:1981-02-01 00:00:00
abstract::The vaginal bleeding patterns observed during the use of the single-rod progestin-only implant, Implanon, compared with those seen during the use of the six-capsule implant, Norplant, have been analyzed. The acceptability of these bleeding patterns was also assessed. An integrated analysis of 13 different trials was d...
journal_title:Contraception
pub_type: 杂志文章,meta分析,收录出版
doi:10.1016/s0010-7824(98)00123-1
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To determine the acceptability of taking mifepristone at home for early medical abortion in the United States. STUDY DESIGN:This prospective, non-randomized, open-label study at six Planned Parenthood centers gave women with pregnancies up to 63 days' gestation seeking medical abortion the choice of taking m...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.contraception.2015.06.026
更新日期:2015-09-01 00:00:00
abstract::The treatment outcomes of 956 women undergoing second trimester termination of pregnancy with mifepristone and gemeprost were studied. The median gestational age was 16 weeks (range: 12-24 weeks). All women were treated with 200 mg mifepristone orally, followed 36 h later with 1 mg vaginal gemeprost administered every...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00219-0
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the initial safety and effectiveness of the intrauterine ball (IUB), a copper intrauterine device that, upon insertion in the uterus, takes a three-dimensional spherical form. STUDY DESIGN:Fifteen women were followed for 1 year, with follow-up visits at 1, 3, 6, 9 and 12 months. RESULTS:The phys...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2013.10.017
更新日期:2014-02-01 00:00:00
abstract::Testosterone (T) treatment suppresses serum gonadotropins and reduces sperm output sufficiently for contraceptive efficacy in approximately 70% of Caucasian men. In the remaining 30% of men, an increase in 5alpha-reductase activity may maintain testicular androgen activity, thus accounting for the failure of sperm sup...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(00)00139-6
更新日期:2000-08-01 00:00:00
abstract::The clinical performance of the Copper T 380A (TCu 380A) and the Lippes Loop intrauterine devices (IUDs) were evaluated for 12 months in a group of 710 women who had one of the two IUDs inserted. Results are from a randomized clinical trial conducted at three collaborating research sites located in three developing co...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0010-7824(95)00119-u
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:Our objective was to explore knowledge, attitudes and beliefs about pregnancy and contraceptive decision-making among reproductive-aged women with cystic fibrosis. STUDY DESIGN:In this qualitative study, we used purposive sampling of reproductive age women enrolled in the Adult Cystic Fibrosis program at Pen...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.05.005
更新日期:2019-09-01 00:00:00
abstract::Levels of contraceptive steroids in breast milk and plasma of lactating women were investigated. 7 lactating women received 150 mg medroxyprogesterone acetate (MPA) 1 week after delivery. 5 women (lactating) took 350 mcg norethisterone (NET) and 2 took 150 mcg d-norgestrel (d-ng) + 30 mcg ethinyl estradiol. Milk an...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(77)90061-0
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Given the need for a 90-day post-Essure hysterosalpingogram (HSG) to confirm proper tubal placement and occlusion, we examined the impact of dedicating a staff nurse to schedule HSG appointments, call with appointment reminders and track HSG compliance for patients who had Essure. STUDY DESIGN:We performed ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.01.019
更新日期:2010-06-01 00:00:00
abstract::To assess how Flemish general practitioners (GPs) are handling the first contraception consultation, we used standardized patients (SPs) as the best method to assess the performance of GPs in daily practice. Thirty GPs got a visit from one of the three SPs. Based on a validated checklist, the SPs scored the performanc...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.12.007
更新日期:2005-06-01 00:00:00
abstract::The long-term effects of tolnidamine on male reproduction and general body metabolism were studied in rabbits (Oryctolagus cuniculus). The study was divided into three groups of 10 animals each. The first group (A) received vehicle alone to serve as controls. The second and third groups (B and C) of animals were admin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(98)00031-6
更新日期:1998-04-01 00:00:00
abstract::The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of spe...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(03)00076-3
更新日期:2003-07-01 00:00:00
abstract:INTRODUCTION:Abortion in Turkey has been legal since 1983 and remains so today. Despite this, in 2012 the Prime Minister declared that, in his opinion, abortion was murder. Since then, there has been growing evidence that abortion access particularly in state hospitals is being restricted, although no new legislation h...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2016.09.009
更新日期:2017-02-01 00:00:00
abstract::A five-year study of NORPLANT II rod implants was undertaken in four large cities and metropolitan areas in eastern China. Designed to test the safety, efficacy and acceptability of these implants, the study involved 1,208 women and was conducted concurrently with a similar study of NORPLANT capsule implants. At the e...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(94)90078-7
更新日期:1994-07-01 00:00:00
abstract::The aim of this study was to develop a mouse model to investigate the effects of long-term progestin-only exposure on endometrial vascular structure. Normal cycling mice received Silastic implants containing either medroxyprogesterone acetate (MPA) or levonorgestrel (LNG) and were dissected after 1, 3 or 6 weeks. Endo...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.04.006
更新日期:2004-10-01 00:00:00
abstract::Surveys undertaken in the 1970s and 1980s suggested that amenorrhea was unacceptable to most women, especially in developing countries. More recent research suggests that increasing numbers of women in the developed world prefer to menstruate less often. In a questionnaire survey of 1001 women attending family-plannin...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/s0010-7824(02)00474-2
更新日期:2003-01-01 00:00:00
abstract::In order to determine whether inhibition of the endometrial estradiol-17 beta-dehydrogenase activity by Cu++ could be one of the factors accounting for the enhanced contraceptive efficacy of copper intrauterine devices (Cu-IUD), the activity of the enzyme was measured in endometrial biopsies from women wearing this de...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(79)90019-2
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Women with cardiac disease have need for effective long-lasting reversible contraception. Women with cardiac disease are at increased risk for bacterial endocarditis. There is limited research regarding the use of intrauterine contraceptive devices (IUD) in women with cardiac disease. STUDY DESIGN:In a pros...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2008.05.006
更新日期:2008-10-01 00:00:00
abstract::Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90020-3
更新日期:1983-06-01 00:00:00
abstract::The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(89)90012-7
更新日期:1989-01-01 00:00:00
abstract::Combined oral contraceptives are undoubtedly popular. By the end of the 1980's, an estimated 63 million married women around the world were using this method of contraception. In Britain, perhaps 95% of all sexually active women have used the pill at some time before their 30th birthday. Commensurate with such widespr...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(95)00095-r
更新日期:1995-06-01 00:00:00