Abstract:
:In a prospective double-blind study of the effects of two low-dose oral contraceptives (OCs) on lipid and lipoprotein metabolism, two groups of eighteen young healthy women selected at random were submitted to a six months' use of either monophasic ethinylestradiol (EE) + desogestrel (DG) or triphasic EE + levonorgestrel (LNG). Total cholesterol (C), triglycerides (TG), phospholipids (PL), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) together with apoproteins A-I, A-II, B and lecithin cholesterol acyltransferase activity (LCAT) were determined in serial plasma samples collected before, at three and six months during, and one month after OC use. Cholesterol and apoproteins (A-I, A-II, B) composition of lipoproteins (HDL-2, HDL-3, LDL) isolated by ultracentrifugation were additionally determined. On Mono-EE + DG, plasma TG (+39.3%, +45.6%), PL (+21.9%, +16.8%) and apo A-I (+35.5%, +23.3%) levels were significantly increased at 3 and 6 months of use; plasma HDL-C (+24%) and Apo A-II (+21.4%) were transiently increased at 3 months. Lipid and apoprotein composition of HDL-2, HDL-3 and LDL were unchanged. On Tri-EE + LNG, a slight but not significant decrease in HDL-C was observed throughout the study while other plasma lipids and apoproteins were unchanged. Ultracentrifugation revealed a lower content of C (-44.2%) and apo A-I (-44.6%) in HDL-2. LCAT activity expressed as molar esterification rate (MER) rose in a more sustained way during EE + DG use than during EE + LNG treatment. Covariance analysis shows a further significant difference between results of both treated groups for the Apo AI/Apo B ratio that was increased by Mono-EE + DG.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Harvengt C,Desager JP,Gaspard U,Lepot Mdoi
10.1016/0010-7824(88)90003-0subject
Has Abstractpub_date
1988-06-01 00:00:00pages
565-75issue
6eissn
0010-7824issn
1879-0518pii
0010-7824(88)90003-0journal_volume
37pub_type
临床试验,杂志文章,随机对照试验相关文献
CONTRACEPTION文献大全abstract::Eight investigators, using a common protocol, studied the use of intramuscular (15S)-15-methyl prostaglandin F2 alpha to abort midtrimester pregnancies which had failed treatment by other methods in 398 cases. Results of treatment of 3 subgroups, defined by reason for primary treatment failure, are presented. The comb...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90088-8
更新日期:1980-12-01 00:00:00
abstract::Presumably, Latino women engage in little family planning because of religious or cultural objections to contraception. The purpose of this study was to examine how acculturation, religion and various demographic factors were related to the family-planning behaviors of Latino women in the United States. Data were coll...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2003.10.011
更新日期:2004-03-01 00:00:00
abstract::Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90098-6
更新日期:1981-02-01 00:00:00
abstract::The mechanism of action of intrauterine devices varies from one type of device to another, although the principle of action is the same, namely, to interfere with the physiology of reproduction at the endometrial level. The biochemical changes of the endometrial tissue and the composition of the uterine fluid have bee...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(87)90058-8
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:This study was conducted to evaluate the effect of levonorgestrel-releasing intrauterine devices (LNG-IUDs) on menorrhagia in patients receiving anticoagulant therapy after cardiac valve replacement. STUDY DESIGN:Forty women with menorrhagia who underwent cardiac valve replacement and were taking anticoagul...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2009.02.007
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:The objectives of this analysis were to 1) estimate prevalence of contraceptive use among women at risk for unintended pregnancy and 2) identify correlates of contraceptive use among women with ongoing or potential need for contraceptive services in Puerto Rico during the 2016 Zika virus (ZIKV) outbreak. ST...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.03.001
更新日期:2020-06-01 00:00:00
abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90107-i
更新日期:1993-01-01 00:00:00
abstract::Seventy-five women with a mean age of 27.5 years who requested Norplant implants for contraception were studied over a five-year period. The patients kept daily diaries of their vaginal bleeding and coital frequency, and were seen at least every six months at which time their weight was measured. This study examines t...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(94)90047-7
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:In 2013, Texas House Bill 2 (HB 2) placed restrictions on the use of medication abortion, which later were nullified with the 2016 FDA-approved mifepristone label. METHODS:Using data collected directly from Texas abortion facilities, we evaluated changes in the provision and use of medication abortion durin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.01.001
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:To assess factors associated with pregnancy fatalism among U.S. adult women. STUDY DESIGN:I used data from the Change and Consistency in Contraceptive Use study, which collected information from a national sample of 4634 U.S. women aged 18-39 at baseline (59% response rate). I assessed pregnancy fatalism ba...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.05.015
更新日期:2018-10-01 00:00:00
abstract::The morphology and the related composition of T-type intrauterine devices (IUDs) made of gold-plated copper were studied in relation to patient complaints. The removed IUDs were examined without pretreatment by scanning electron microscopy and energy dispersive x-ray spectroscopy. Besides the previously found incrusta...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.03.006
更新日期:2004-08-01 00:00:00
abstract::A study has been made of the serum 25-hydroxycholecalciferol (25-HCC) levels in six groups of women. Significant differences were found between the one pregnant group and the two reference groups as well as between the one pregnant group and two of the three groups using oral contraceptives. No significant differences...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90029-9
更新日期:1981-04-01 00:00:00
abstract::RU 486 and three of its metabolites (RU 42633-monodemethyl, RU 42848-didemethyl, and RU 42698-hydroxymetabolite) were determined by HPLC in plasma from nine non-pregnant and 36 pregnant women. Each non-pregnant subject took an oral dose of RU 486 (25, 100, 400 and 600 mg consecutively) once per menstrual cycle. Six of...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90004-q
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:The Affordable Care Act (ACA) will expand health care coverage to low-income Americans. Contraception services are a mandated component of ACA plans. STUDY DESIGN:A decision-analytic model was developed to compare the costs and outcomes of the current versus the proposed plan for contraceptive coverage (Fed...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.06.009
更新日期:2013-02-01 00:00:00
abstract::The pharmacokinetics and pharmacodynamic effects of two doses of norethisterone (5mg and 3mg) used as a 'visiting pill' were investigated. There were no significant differences in the pharmacokinetics of the two doses except for the peak concentration achieved and the bioavailability as assessed by the area under the ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90008-9
更新日期:1986-09-01 00:00:00
abstract::Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were measured in seven volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. Blood samples were collected twice weekly during a mean of 93 days immediately postmenstrually and during a mean of 41 days over the twelfth to...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90003-7
更新日期:1980-03-01 00:00:00
abstract::A mixture of two partially triterpenoid saponins (Tg), isolated from Acacia auriculiformis was tested for sperm immobilizing activity by using in vitro system. The lowest concentration (ED) required for an obvious immobilization of human sperm by using a modified Sander-Cramer test was found to be 0.35 mg/ml in physio...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(91)90137-5
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Mirena is a levonorgestrel-releasing intrauterine system (LNG-IUS) that provides highly effective and long-acting progestogen-only contraception. OBJECTIVE:The objective of this study was to analyze the possible effects of using LNG-20 microg IUS on breast-feeding performance, infant growth and infant devel...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2005.04.004
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations. STUDY DESIGN:We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definiti...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.03.007
更新日期:2017-06-01 00:00:00
abstract::A prospective, randomized clinical trial observed the effects of Norplant long-term contraceptive implants and domestic implants similar to Norplant on bone mineral density and bone metabolism in female acceptors for 1 year. Bone mineral density (BMD) and bone mineral content (BMC) of lumbar 2-4 and proximal femur of ...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(99)00080-3
更新日期:1999-09-01 00:00:00
abstract::The purpose of this study was to investigate the efficacy and the acceptability of Prazosin as a male contraceptive pill. Acceptable antifertility drugs for men are proving difficult to produce, and the possibility of using pharmacological agents to block selectively or to inhibit normal sperm transport through the ma...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(88)90008-x
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:To demonstrate the feasibility and safety of training midlevel healthcare providers (midwives and family nurses) to provide medical abortion and postabortion contraception in underserved areas in Kyrgyzstan. STUDY DESIGN:This was an implementation study at four referral facilities and 28 Felsher Obstetric Po...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.11.002
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To describe medroxyprogesterone acetate (MPA) levels among Kenyan depot medroxyprogesterone acetate (DMPA) users in the FEM-PrEP HIV prevention trial, and to compare MPA levels between ARV for HIV prevention (treatment) and placebo groups. STUDY DESIGN:We measured MPA in previously collected plasma samples f...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2016.03.003
更新日期:2016-07-01 00:00:00
abstract::This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90066-8
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:There is a lack of information concerning the decision factors and sources of information influencing women who purposefully deviate from the prescribed use of their combined hormone contraceptives to exert elective control of their scheduled bleeding. STUDY DESIGN:A self-administered email survey of schedu...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.12.012
更新日期:2013-09-01 00:00:00
abstract::This study examines contraceptive delivery characteristics and their association with contraceptive behavior. Data were collected in telephone interviews from a national sample of 1057 women who were using female contraceptives. The overwhelming majority of the sample obtained contraceptive services from gynecologists...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90074-7
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasoni...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2009.12.001
更新日期:2010-04-01 00:00:00
abstract::The effect of consecutively injecting a one-a-month contraceptive (norethisterone enantate 50 mg with estradiol valerate 5 mg) for one year on haematological parameters was evaluated in 42 Chinese women. The healthy volunteers were randomly allocated to either the treatment group (22) or a control group (20). Blood sa...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(90)90052-w
更新日期:1990-10-01 00:00:00
abstract::The effect of 2 long-acting injectables on the plasma protein-bound carbohydrate components and serumucoid when taken for different periods, was illustrated in 100 women of childbearing age. 40 acted as controls, 30 took depot-medroxyprogesterone acetate (DMPA), and 30 took norethisterone enanthate (NET-EN). DMPA wa...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(77)90051-8
更新日期:1977-10-01 00:00:00
abstract::A morphometric study was undertaken to quantitate vessel numbers in uterine biopsies from a control group of patients, patients with dysfunctional uterine bleeding and patients taking low dose norethisterone or levonorgestrel. Vessels were counted at the endometrial/myometrial junction and in the functional endometriu...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(86)80016-6
更新日期:1986-12-01 00:00:00