当前位置： SCI文献检索 > CONTRACEPTION期刊下所有文献 > Nitrites and L-citrulline levels in copper intrauterine device users.

Nitrites and L-citrulline levels in copper intrauterine device users.

Abstract：

:The mechanism of copper in limiting intrauterine infections in intrauterine device (Cu IUD) users is poorly understood. Copper ions may enhance the release of reactive oxygen radicals, which in turn decrease the release of reactive nitrogen intermediates (RNI). RNI are known to have bactericidal effect. The present study compares the levels of RNI prior to Cu-T insertion and at different post-insertion intervals up to 12 weeks. The decrease in RNI was evident by one week and continued until 12 weeks. Therefore, the bactericidal effect of copper in IUD is via reactive oxygen intermediates. The superoxide anion inactivates this active intermediate nitric oxide. Therefore, excess of superoxide radical will markedly shorten the half-life of nitric oxide but will not prevent its conversion to nitrites and nitrates. :Copper ions may enhance the release of reactive oxygen radicals that decrease the release of reactive nitrogen intermediates (RNIs), known to have a bactericidal effect. The capability of the Copper-T IUD to generate RNIs was investigated in women seeking IUD insertion at a family planning clinic in Chandigarh, India. A significant decrease in nitric oxide levels was recorded from pre-insertion to 1 week post-insertion. Moreover, the values at 4 weeks' post-insertion were significantly lower than those at 1 week, and the 12 weeks' post-insertion level was lower than that recorded at 4 weeks. Uterine aspirate L-citrulline levels at 1 week post-insertion were significantly lower than pre-insertion levels; again, values at 4 and 12 weeks post-insertion were significantly less than those of the receding levels. There was no significant difference in levels of nitrites or serum L-citrulline before and after IUD insertion. Although the exact mechanism of the decrease in RNI levels at the local site after IUD insertion is unknown, it appears related to the sterile intrauterine milieu. At the peak of copper release, the inflammatory cells are activated to release reactive oxygen radicals. Copper potentiates the effect of superoxide dismutase, which influences the half-life of nitric oxide, but does not prevent its conversion to nitrites and nitrates.

journal_name

Contraception

journal_title

Contraception

authors

Pradhan M,Gupta I,Ganguli NK

doi

10.1016/s0010-7824(97)00037-1

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

315-8

issue

eissn

0010-7824

issn

1879-0518

pii

S0010782497000371

journal_volume

pub_type

杂志文章

在线工具

Nitrites and L-citrulline levels in copper intrauterine device users.