Abstract：
:Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg Mifepristone or placebo for 24 and 12 hours before vacuum aspiration. An objective method has been designed to measure the force necessary to step-wise dilate the cervix from 4 to 11 mm. Significant (p less than 0.05) changes in the stiffness of the cervix were demonstrated in patients treated with Mifepristone, reflecting ripeness. The treatment was simple and had no side effects.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Rådestad A,Christensen NJ,Strömberg Ldoi
10.1016/0010-7824(88)90102-3subject
Has Abstractpub_date
1988-09-01 00:00:00pages
301-12issue
3eissn
0010-7824issn
1879-0518pii
0010-7824(88)90102-3journal_volume
38pub_type
临床试验,杂志文章,随机对照试验相关文献
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