Abstract：
:Biochemical studies with a once-a-month contraceptive pill containing 2 mg quinestrol and 2.5 mg quingestanol acetate were undertaken during a period of 24 months. The 1st pill was given on the 2nd day of the menstrual cycle and the 2nd on the 22nd day of the same cycle; thereafter the pills were given every 28th day from the last pill. Blood samples were obtained before therapy and after 6, 12, 18, and 24 pills. Hemoglobin, packed cell volume, liver function tests, and serum proteins were not markedly altered. There was a significant (p less than .001) elevation in serum triglycerides, free fatty acids, phospholipids, and cholesterol after the ingestion of 6-12 pills in 17 women who were continuously followed for 2 years; however, serum triglycerides and phospholipids were less after the ingestion of 12 pills than after 6 pills. It appeared that these changes in serum lipids were similar to those reported in women taking daily combination pills. In no case did the serum lipids exceed the upper limit of normal. The drop-out rate was high after 12 pills. Th nonacceptability was of greater significance, therefore, than the metabolic effects in these trials.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Donde UM,Virkar KDdoi
10.1016/0010-7824(75)90065-7subject
Has Abstractpub_date
1975-06-01 00:00:00pages
681-8issue
6eissn
0010-7824issn
1879-0518pii
0010-7824(75)90065-7journal_volume
11pub_type
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