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The short-term effects of a low-dose oral contraceptive on glucose metabolism, plasma lipids and blood clotting factors.

Abstract：

:Twelve young women were prospectively evaluated for the short-term metabolic effects of a low-dose oral contraceptive containing 30 micrograms ethinyl estradiol and 150 micrograms levonorgestrel. To each volunteer a 50 g glucose challenge was administered monthly as a screening test for changes in the glucose metabolism. Fasting and 30 minutes glucose and insulin values were measured and blood specimens were collected for determination of fasting triglycerides, cholesterol and blood clotting factors II, VII, X. During treatment the fasting plasma glucose level decreased significantly in the first two cycles and then normalized. No change in incremental glucose values was observed. Fasting insulin concentrations, incremental insulin values and the insulinogenic index did not change during the study period. Total plasma cholesterol values decreased during treatment, whereas the plasma triglyceride levels were unaffected. Immediately after tablet intake, an increase was found in the blood clotting factors and the elevated levels continued constantly throughout the study period. Comparing the data from the present study with data from previous investigations on low-dose ethinyl estradiol/levonorgestrel compounds, there seems to be no difference in the influence on blood clotting factors, glucose and lipid metabolism between treatment for 3 and 6 months. From the study, it is concluded that the impact of oral contraceptives on metabolic functions may emerge during the initial treatment cycles. :12 young women were prospectively evaluated for the shortterm metabolic effects of a low-dose oral contraceptive (OC) containing 30 mcg ethinyl estradiol and 150 mcg levonorgestrel. To each volunteer, a 50 mcg glucose challenge was administered monthly as a screening test for changes in the glucose metabolism. Fasting and 30 minutes glucose and insulin values were measured and blood specimens were collected for determination of fasting triglycerides, cholesterol, and blood clotting factors 2, 7 and 10. During treatment, the fasting plasma glucose level decreased significantly in the 1st 2 cycles and then normalized. No change in incremental glucose values was observed. Fasting insulin concentrations, incremental insulin values, and the insulinogenic index did not change during the study period. Total plasma cholesterol values decreased during treatment, whereas the plasma triglyceride levels were unaffected. Immediately after tablet intake, an increase was found in the blood clotting factors and the elevated levels continued constantly thoughout the study period. Comparing the data from the present study with data from previous investigations on low dose ethinyl estradiol/levonorgestrel compounds, there seems to be no difference in the influence on blood clotting factors, glucose, and lipid metabolism between treatment for 3 and 6 months. From the study, it is concluded that the impact of OCs on metabolic functions may emerge during the initial treatment cycles.

journal_name

Contraception

journal_title

Contraception

authors

Skouby SO,Wagner HH,Andersen O

doi

10.1016/0010-7824(83)90080-x

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

489-99

issue

eissn

0010-7824

issn

1879-0518

pii

0010-7824(83)90080-X

journal_volume

pub_type

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The short-term effects of a low-dose oral contraceptive on glucose metabolism, plasma lipids and blood clotting factors.