Abstract：
BACKGROUND:Barriers to intrauterine device (IUD) use in nulliparous women include fear of pain with insertion and provider perception of difficulty with insertion. The goal of this study was to evaluate whether misoprostol prior to IUD insertion in nulliparous women eased insertion and decreased pain. STUDY DESIGN:This was a double-blinded, randomized, controlled trial. Nulliparous women requesting an IUD were randomized to buccal placement of 400-mcg misoprostol or placebo. Provider ease of insertion and patient-reported pain were measured using a 100-mm visual analogue scale. RESULTS:Seventy-three subjects completed the study. Baseline characteristics were similar between groups. Provider perception of ease of insertion was not different between study and control groups (28.97 mm, 22.33 mm, p=.18). Pain immediately prior to IUD insertion (10.84 vs. 2.11; p=.003) and after IUD insertion (46.50 vs. 35.14; p=.040) was higher for those in the study group compared to the control group. CONCLUSION:This study demonstrates that it is not helpful to provide misoprostol for cervical ripening prior to insertion of IUDs as it does not improve ease of insertion for provider or decrease reported pain for the woman, and it may increase women's pain experience with insertion. IMPLICATION STATEMENT:Our study demonstrates that providers do not perceive nulliparous IUD insertion as difficult; women do experience pain with insertion but find the experience acceptable. The addition of misoprostol for cervical ripening prior to insertion does not ease insertion for providers and increases the pain level experienced by women.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Lathrop E,Haddad L,McWhorter CP,Goedken Pdoi
10.1016/j.contraception.2013.07.011subject
Has Abstractpub_date
2013-12-01 00:00:00pages
725-9issue
6eissn
0010-7824issn
1879-0518pii
S0010-7824(13)00544-1journal_volume
88pub_type
杂志文章,随机对照试验相关文献
CONTRACEPTION文献大全abstract：OBJECTIVE:The aim of this study was to report on the safety and efficacy of an evidence-based medical abortion regimen utilizing 200 mg of mifepristone orally followed by home use of 800 mcg misoprostol buccally 24-48 h later through 63 days estimated gestational age. STUDY DESIGN:We analyzed outcomes in women present...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.01.005
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:This study investigated the effects of adding levomefolate calcium 0.451 mg (the calcium salt of L-5-methyltetrahydrofolate; Metafolin®) to an oral contraceptive containing ethinylestradiol (EE) 20 mcg/drospirenone (drsp) 3 mg on folate levels in healthy women seeking contraception. STUDY DESIGN:In this ran...
journal_title：Contraception
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.contraception.2011.05.013
更新日期：2012-01-01 00:00:00
abstract：:The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II,...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(00)00184-0
更新日期：2000-12-01 00:00:00
abstract：:The pharmacology and clinical assessment of existing first generation once-a-month combined injectable contraceptives, mainly Deladroxate and Chinese Injectable No. 1, are reviewed. Although these two types of monthly injectables have been used in some million women in China and Latin America, Deladroxate needs indept...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(94)90033-7
更新日期：1994-04-01 00:00:00
abstract：OBJECTIVES:All Tanzanian abortion estimates rely on health facility data that do not take into account completely the incidence of abortion. This papers aims to estimate the lifetime incidence of induced abortion in Arusha, Tanzania via direct and double list-experiment methods using community data and evaluate outcome...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.10.013
更新日期：2021-02-01 00:00:00
abstract：:The continuation rate at the end of this five-year clinical study was 60% with no accidental pregnancy occurring throughout the five years. The post-removal conception rate in women desiring pregnancy was 92% at the end of two years. The majority of acceptors described the overall experience with the implants as favou...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(92)90139-k
更新日期：1992-01-01 00:00:00
abstract：:The effects of phenytoin treatment on plasma concentrations of norethisterone (NET) was studied in 7 healthy female rhesus monkeys. Before phenytoin treatment was started each monkey received an oral dose of 0.5 mg NET and 2 weeks later the same dose was given intravenously. On both occasions, plasma concentrations of...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(83)80021-3
更新日期：1983-04-01 00:00:00
abstract：BACKGROUND:Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. STUDY DESIGN:Six healthy postmenopausal volun...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2007.08.006
更新日期：2007-12-01 00:00:00
abstract：:RU 486 and three of its metabolites (RU 42633-monodemethyl, RU 42848-didemethyl, and RU 42698-hydroxymetabolite) were determined by HPLC in plasma from nine non-pregnant and 36 pregnant women. Each non-pregnant subject took an oral dose of RU 486 (25, 100, 400 and 600 mg consecutively) once per menstrual cycle. Six of...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(93)90004-q
更新日期：1993-08-01 00:00:00
abstract：:A large introductory study of Cyclofem, a once-a-month injectable contraceptive, was conducted in three Mexican provinces. A total of 3457 healthy women participated: 640 women from rural areas (community-based component) and 2817 women from urban and suburban areas (health center-based component). A total of 20,316 w...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(98)00062-6
更新日期：1998-07-01 00:00:00
abstract：:This study examines the efficacy and side effects of 15-methyl-prostaglandins F2alpha (PGF2a) free acid administered intramuscularly for midtrimester abortion. 50 healthy women aged 14 to 37 years and between 12 to 18 weeks gestation were randomly selected from the abortion clinic at the Los Angeles County/USC Medica...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(75)90107-9
更新日期：1975-05-01 00:00:00
abstract：:The efficacy and side effects of a new synthetic compound, 16-phenoxy-W-17, 18, 19, 20-tetranor prostaglandin E2 methylsulfonylamide, for menstrual induction. The study was conducted in an outpatient clinic in 240 patients with a delay in menstruation of 6-14 days. In 206 patients (86%) the immunologic pregnancy tes...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(77)90049-x
更新日期：1977-10-01 00:00:00
abstract：:The aim of this study was to characterize the bleeding pattern, the outcome of pregnancies and the levonorgestrel plasma levels associated with method failures in Norplant implants users. Nineteen pregnancies are reported in 458 woman and 21,589 woman-months observed during the first eight years of Norplant use. Pregn...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(86)90096-x
更新日期：1986-04-01 00:00:00
abstract：OBJECTIVE:The study was conducted to evaluate the effect of Carraguard vaginal gel containing 0.75 mg of levonorgestrel (CARRA/LNG gel) administered in a single dose at different stages of follicle development over subsequent follicle rupture and hormonal levels. METHOD:Randomized, blinded, cross-over study comparing ...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2007.04.005
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVES:The aim of this survey was to understand US women's contraception journey from her first prescribed method to her current one including reasons for choosing and stopping/switching methods, healthcare provider relationships, and bleeding preferences. STUDY DESIGN:We administered a nationally-representative, ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.09.010
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Emergency contraception (EC) does not always work. Clinicians should be aware of potential risk factors for EC failure. STUDY DESIGN:Data from a meta-analysis of two randomized controlled trials comparing the efficacy of ulipristal acetate (UPA) with levonorgestrel were analyzed to identify factors associat...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2011.02.009
更新日期：2011-10-01 00:00:00
abstract：:Separate crossover studies compared the bioavailability of oral vs. vaginal routes of administration for the Yuzpe (n=5) and levonorgestrel regimens (n=4) of emergency contraception. Twice the standard dose of the Yuzpe regimen (200 microg of ethinyl estradiol, 1000 microg of levonorgestrel) or the levonorgestrel regi...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/j.contraception.2004.09.009
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVES:To assess shorter mifepristone-misoprostol intervals compared to current guidelines for second trimester medical abortion on total abortion time (mifepristone to fetal expulsion) and induction time (first misoprostol to fetal expulsion). METHODS:This retrospective cohort study included women who elected for...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.06.009
更新日期：2020-11-01 00:00:00
abstract：:Levels of contraceptive steroids in breast milk and plasma of lactating women were investigated. 7 lactating women received 150 mg medroxyprogesterone acetate (MPA) 1 week after delivery. 5 women (lactating) took 350 mcg norethisterone (NET) and 2 took 150 mcg d-norgestrel (d-ng) + 30 mcg ethinyl estradiol. Milk an...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(77)90061-0
更新日期：1977-12-01 00:00:00
abstract：CONTEXT:Progestins delivered by a variety of routes have been demonstrated, in addition to their high contraceptive effect, to have substantial benefits in the treatment of various gynecological disorders, and the intrauterine route has particular efficacy in treating endometrial and myometrial disorders. It should be ...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2006.12.013
更新日期：2007-06-01 00:00:00
abstract：:The aim of this study was to determine the effect of a short-term ethinyl estradiol/levonorgestrel medication on blood flow in the uterine arteries in postmenopausal women in a prospective placebo-controlled double-blind study. Twenty-one healthy postmenopausal woman at least 2 years after menopause received 60 microg...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(97)00122-4
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations. STUDY DESIGN:We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definiti...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.03.007
更新日期：2017-06-01 00:00:00
abstract：:To test the contraceptive efficacy of norethindrone (NET), the effect of NET on peripheral plasma levels of progesterone and estradiol after ovulation was investigated, since low levels of ovarian steroids might affect the postovulatory endometrium and thereby impair normal blastocyst implantation. Two studies were ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(72)90011-x
更新日期：1972-06-01 00:00:00
abstract：PURPOSE:The goal of this paper is to review the imaging methods required for localizing nonpalpable Implanontrade mark. METHOD:Different localization methods for nonpalpable Implanon rods are summarized, and clinical guidance is provided as to how best to localize such implants. RESULTS:In the great majority of cases...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2005.10.009
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the need for and outcome of self-administered medical abortion with mifepristone and misoprostol in Brazil, provided through Women on Web, a global telemedicine abortion service. STUDY DESIGN:A retrospective case review of women from Brazil who contacted Women on Web in 2011. Information from the...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.11.005
更新日期：2014-02-01 00:00:00
abstract：:Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(81)90098-6
更新日期：1981-02-01 00:00:00
abstract：:DL111-IT, a non-hormonal contragestional agent, revealed synergistic effects in combination with mifepristone (RU486) in some species. The present study was undertaken to clarify the role of DL111-IT when used alone or plus RU486 on uterine polyamines biosynthesis, histologic alteration of decidual cells, and antifert...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(01)00197-4
更新日期：2001-05-01 00:00:00
abstract：:Partially purified human ovarian follicular fluid peptide (hGF2) was administered during follicular phase in 5 bonnet monkeys. In control as well as hGF2-injected animals, ovulation was synchronized by treatment with FSH, Pergonal and hCG. All the 5 control bonnet monkeys showed plasma estradiol peak followed by incre...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(92)90060-7
更新日期：1992-04-01 00:00:00
abstract：:Experiments were conducted to determine whether oral administration of a water extract of P. dodecandra had significant effects on reproduction in mice. The work is based on earlier reports in this journal that butanol extracts of the berries of this plant had spermatocidal properties in vitro and blastocidal activity...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(87)80006-9
更新日期：1987-02-01 00:00:00
abstract：OBJECTIVE:This study was aimed to evaluate a marketed mineralo-herbal preparation containing plants known to have potent contraceptive activity, or contraindicated for use during pregnancy in folklore/ancient Indian literature and recommended for use as an appetizer and headache, hyperacidity and chronic constipation r...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2005.05.026
更新日期：2005-12-01 00:00:00
