Abstract：
OBJECTIVES:To assess shorter mifepristone-misoprostol intervals compared to current guidelines for second trimester medical abortion on total abortion time (mifepristone to fetal expulsion) and induction time (first misoprostol to fetal expulsion). METHODS:This retrospective cohort study included women who elected for a second trimester medical abortion with mifepristone and misoprostol at an academic tertiary medical center in the United States from January 2008 to June 2018. We abstracted times of mifepristone administration, first dose of misoprostol, and fetal expulsion from the medical record. We assessed outcomes based on the shorter intervals <12 h and 12 to 24 h compared to the guideline mifepristone-misoprostol interval (24-48 h). RESULTS:The study population included eighty-nine women, 47, 28, and 14 women in the <12 h, 12 24 h, guideline (24-48 h) groups, respectively. The cohort had a median gestational age of 220/7 weeks (range: 150/7-270/7) and parity of 1 (range: 0-5) with no differences observed between groups. Total abortion times were 20.7 h (range: 3.7-46.9), 30.6 h (16.7-48.0), and 42.8 h (32.7-62.6), respectively (p < 0.001). Induction times were 12.9 h (range: 1.2-36.6), 11.7 h (2.0-35.2), and 9.3 h (5.3-16.5), respectively. Fetal expulsion within 12 h of first misoprostol dose occurred in 22 (47%), 14 (50%), and 9 (64%), respectively (p = 0.52). CONCLUSIONS:Shorter mifepristone-misoprostol intervals (less than 24 h) significantly decrease the total abortion time while maintaining a clinically similar induction time. IMPLICATIONS:Shortening the mifepristone-misoprostol interval in second trimester medical abortion significantly decreases the total abortion time which may be preferable to some women or health systems.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Henkel A,Lerma K,Blumenthal PD,Shaw KAdoi
10.1016/j.contraception.2020.06.009subject
Has Abstractpub_date
2020-11-01 00:00:00pages
327-331issue
5eissn
0010-7824issn
1879-0518pii
S0010-7824(20)30186-4journal_volume
102pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:Forty-three homozygous (SS) female sickle cell anemic patients with a history of at least one painful crisis per month and desiring a reversible contraceptive were administered DMPA/3 months or Microgynon monthly. A third group of 16 surgically sterilized patients served as control. Patients were followed for 1 year t...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(97)00156-x
更新日期：1997-11-01 00:00:00
abstract：:The objectives of the study were to assess the ability of the Femcap, a new vaginal contraceptive device made of silicone and designed to fit snugly around the cervix to prevent the penetration of sperm into midcycle cervical mucus when used with and without spermicide; and to compare it with the standard contraceptiv...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(97)00098-x
更新日期：1997-08-01 00:00:00
abstract：:A chemically deglycosylated derivative of ovine luteinizing hormone (LH) exhibited appreciable binding to the receptor but had minimal steroidogenic activity. In immature female rats primed with pregnant mare serum gonadotropin, the deglycosylated LH showed low ovulation-inducing activity. Ovulation induced by ovine L...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90037-2
更新日期：1980-06-01 00:00:00
abstract：:In 1991, the source of public sector condom supplies in an African country changed from USAID to WHO. Following a complaint, the two types of condoms were sampled and compared. Laboratory tests indicated that the new-style condoms were of adequate quality, but a number of differences were noted between the two types. ...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(95)00183-b
更新日期：1995-10-01 00:00:00
abstract：:Roussel Uclaf in partnership with the INSERM unit of Prof. E.E. Baulieu first discovered mifepristone (RU486) as part of a large research program on steroidal compounds with antihormone properties. Exhibiting a strong affinity to the progesterone and the glucocorticoid receptors, mifepristone exerted competitive antag...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(03)00171-9
更新日期：2003-12-01 00:00:00
abstract：:The effect of alpha-chlorohydrin (3-chloropropan-1,2-diol) on the metabolism of D-[U-14C]-fructose and L-[U-14C]-lactate by washed boar sperm has been investigated. Whereas alpha-chlorohydrin at concentrations as low as 0.1 mM inhibited the metabolism of fructose and led to an increase in the utilization of endogenous...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90103-1
更新日期：1980-11-01 00:00:00
abstract：OBJECTIVE:Evaluating decisional certainty is an important component of medical care, including preabortion care. However, minimal research has examined how to measure certainty with reliability and validity among women seeking abortion. We examine whether the Decisional Conflict Scale (DCS), a measure widely used in ot...
journal_title：Contraception
pub_type： 杂志文章,多中心研究
doi：10.1016/j.contraception.2016.09.008
更新日期：2017-03-01 00:00:00
abstract：:The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II,...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(00)00184-0
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:The objective was to describe the efficacy of medical abortion using mifepristone and misoprostol for gestations less than 6 weeks. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of mifepristone and misoprostol abortion at gestational ages <42 da...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.09.006
更新日期：2018-02-01 00:00:00
abstract：:Histopathological and biochemical effects of gossypol acetate (GA) on pituitary-gonadal axis were investigated. 10 and 25 mg GA/kg were administered orally to sexually mature adult male Wistar rats for 4 and 5 weeks, respectively. STH and LTH/PRL cells showed no significant changes as compared to those of controls whi...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(92)90162-m
更新日期：1992-05-01 00:00:00
abstract：:The aim of this prospective study was the follow-up for 2 years in symptoms, serum prolactin (PRL) levels, and radiological aspects of a group of young patients using oral contraceptives (OC) with hyperprolactinemia. A total of 16 hyperprolactinemic women (eight with idiopathic hyperprolactinemia and eight with pituit...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(98)00069-9
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Mirena is a levonorgestrel-releasing intrauterine system (LNG-IUS) that provides highly effective and long-acting progestogen-only contraception. OBJECTIVE:The objective of this study was to analyze the possible effects of using LNG-20 microg IUS on breast-feeding performance, infant growth and infant devel...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2005.04.004
更新日期：2005-11-01 00:00:00
abstract：:Lonidamine (LND) [1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid] is a well-known antispermatogenic drug. The aim of this study was to identify its possible long-term sequelae on the reproductive system of mice as compared with rats, where most data have been obtained until now. Sexually mature CD1 male mice wer...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2005.05.019
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVES:To examine trends and utilization patterns of NYC abortion services by nonresidents since growing abortion restrictions across many states could drive women to seek care in less restrictive jurisdictions including NYC. STUDY DESIGN:We used data from Induced Termination of Pregnancy certificates filed with t...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.05.008
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the effectiveness of a refined theory-based Interactive Postpartum Sexual Health Education Program to enhance postpartum women's effective contraceptive behavior. STUDY DESIGN:Participants (N=250) were randomized to three groups. Experimental Group A received our interv...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2010.11.008
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:We examined the men's attitudes and perceptions toward the concept of female nonsurgical permanent contraception (NSPC) or novel approaches to permanent contraception (PC) that do not require incisions or surgical equipment/hysteroscope. STUDY DESIGN:Cross-sectional survey of married/partnered men in Portlan...
journal_title：Contraception
pub_type： 杂志文章,多中心研究
doi：10.1016/j.contraception.2015.03.006
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:We sought to qualitatively understand patients' experiences with digoxin as a step before dilation and evacuation (D&E). STUDY DESIGN:We recruited English-speaking women from one abortion health center where digoxin is routinely used before D&E. We interviewed participants one to three weeks after the D&E ab...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.02.004
更新日期：2018-06-01 00:00:00
abstract：:Twelve young women were prospectively evaluated for the short-term metabolic effects of a low-dose oral contraceptive containing 30 micrograms ethinyl estradiol and 150 micrograms levonorgestrel. To each volunteer a 50 g glucose challenge was administered monthly as a screening test for changes in the glucose metaboli...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(83)90080-x
更新日期：1983-11-01 00:00:00
abstract：:The potential use of tamoxifen, a nonsteroidal antiestrogen, as an antifertility agent was studied in the long-tailed macaque (Macaca fascicularis). Twenty-six cycling females were bred, then treated with a single oral dose of tamoxifen (5 mg/kg) (N = 13) or vehicle (N = 13) on day 4 post-ovulation. Serum progesterone...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(93)90047-b
更新日期：1993-03-01 00:00:00
abstract：OBJECTIVE:To estimate the effect of increased body weight and body mass index (BMI) on pregnancy rates with levonorgestrel (LNG) 1.5mg used as emergency contraception (EC). METHODS:The study reviewed data from 6873 women in four WHO-HRP randomized trials on EC conducted between 1993 and 2010. Participants took either ...
journal_title：Contraception
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.contraception.2016.08.001
更新日期：2017-01-01 00:00:00
abstract：:An injectable method of obtaining vas deferens occlusion is presented. The agent used is styrene maleic anhydride (SMA) with dimethyl sulphoxide as the solvent. The special feature of the approach is that after a period of time, spermatozoa passage is spontaneously reestablished. By varying the dose of SMA administere...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(90)90073-5
更新日期：1990-03-01 00:00:00
abstract：:A five-year study of NORPLANT II rod implants was undertaken in four large cities and metropolitan areas in eastern China. Designed to test the safety, efficacy and acceptability of these implants, the study involved 1,208 women and was conducted concurrently with a similar study of NORPLANT capsule implants. At the e...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/0010-7824(94)90078-7
更新日期：1994-07-01 00:00:00
abstract：:A study was undertaken to determine whether the combination of oral tamoxifen and moistened misoprostol administered vaginally was superior to that of placebo and moistened misoprostol administered vaginally for elective termination of early pregnancies.A clinical trial was conducted with a study group of 150 healthy ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(99)00105-5
更新日期：1999-12-01 00:00:00
abstract：:This prospective, open-label, randomized trial of healthy adult women up to 9 weeks pregnant compared mifepristone 200 mg followed 2 days later with misoprostol 400 microg orally versus misoprostol 800 microg vaginally. The study was interrupted after the oral misoprostol group experienced a higher than expected failu...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0010-7824(02)00366-9
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:The study was conducted to compare lost to follow-up (LTFU) rates in women having a medical abortion who chose follow-up by in-office ultrasound assessment or serum beta human chorionic gonadotropin (β-hCG) testing. METHODS:This retrospective chart review included 865 women who underwent medical abortion in...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2011.09.007
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVES:We aimed to determine the efficacy of fennel and low-dose combined oral contraceptive (LD-COC) on inducing menstrual bleeding and method continuation in women using depot medroxyprogesterone acetate (DMPA) who had no menstrual bleeding within the previous 45 to 140 days. STUDY DESIGN:In this double-blind do...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2014.05.001
更新日期：2014-10-01 00:00:00
abstract：:A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1997-10-01 00:00:00
abstract：:A number of case-control studies published in recent years have shown an apparent increase in the risk of venous thromboembolism (VTE) associated with the use of third-generation oral contraceptives (OCs) compared with second-generation OCs. However, it is thought that these studies were subject to a number of biases ...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/s0010-7824(00)00146-3
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVES:This open-label non-inferiority study assessed efficacy of a common outpatient medical abortion regimen among people with pregnancies 64-70 days and 71-77 days of gestation. STUDY DESIGN:We defined non-inferiority by a 6% margin of method success. People with intrauterine pregnancies 64-77 days' gestational...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.01.009
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To assess the cost-effectiveness of self-injected subcutaneous depot medroxyprogesterone acetate (DMPA-SC) compared to health-worker-administered intramuscular DMPA (DMPA-IM) in Uganda. STUDY DESIGN:We developed a decision-tree model with a 12-month time horizon for a hypothetical cohort of approximately 1 m...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.07.137
更新日期：2018-11-01 00:00:00
