Norethisterone levels in maternal serum and milk after intramuscular injection of norethisterone oenanthate as a contraceptive.

Abstract:

:There is concern that the breast-fed infant whose mother is receiving intra-muscular progestogens for contraception will be exposed to significant quantities of the steroid. Norethisterone levels in maternal serum and milk were studied throughout an injection interval after intramuscular administration of 200mg norethisterone oenanthate. Milk samples were taken at the beginning and at the end of the feed. Norethisterone concentrations in milk were very much lower, but declined more slowly, than serum concentrations. Post-suckling concentrations were higher than pre-suckling concentrations. Experiments in adults receiving an oral dose of norethisterone in cow's milk comparable to that ingested by an infant in a day resulted in low serum levels. It is concluded that only very low concentrations of norethisterone would be present in the infant's circulation. :There is concern that the breastfed infant whose mother is receiving intramuscular progestogens for contraception will be exposed to significant quantities of the steroid. Norethisterone levels in maternal serum and milk were studied throughout an injection interval after intramuscular administration of 200 mg norethisterone enanthate. Milk samples were taken at the beginning and end of the feed. Norethisterone concentrations in milk were much lower but declined more slowly than serum concentrations. Postsuckling concentrations were higher than presuckling concentrations. Experiments in adults receiving an oral dose of norethisterone in cow's milk comparable to that ingested by an infant in a day resulted in low serum levels. It is concluded that only very low concentrations of norethisterone would be present in the infant's circulation.

journal_name

Contraception

journal_title

Contraception

authors

Fotherby K,Towobola O,Muggeridge J,Elder MG

doi

10.1016/0010-7824(83)90073-2

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

405-11

issue

5

eissn

0010-7824

issn

1879-0518

pii

0010-7824(83)90073-2

journal_volume

28

pub_type

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