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Comparative multicentre trial of three IUDs inserted immediately following delivery of the placenta.

Abstract：

:A multinational comparative trial of three IUDs (Copper 7, Lippes loop size D and the Postpartum T) randomly inserted immediately following delivery of the placenta was conducted in six centres. A total of 841 women entered the study. As the predetermined termination indices for expulsions were exceeded at six months the trial was prematurely closed. An excess of expulsions during the first 48 hours following insertion was observed for the Lippes loop compared to the other devices. At six months the expulsion rate for the Lippes loop was significantly higher than that for the Copper 7. In addition, the discontinuation rate for the Lippes loop at 12 months was significantly higher than that for the Copper 7. There were no significant differences in either the expulsion rates or the discontinuation rate at six or twelve months between the postpartum T and the other devices. At 12 months the pregnancy rates with all three devices was high; there were no ectopic pregnancies. Considerable between-centre differences were observed, particularly for expulsion rates. Possible reasons for this are discussed and future research lines are suggested. :A multinational comparative of 3 IUDs (Copper 7, Lippes Loop D, and the Postpartum T) randomly inserted immediately following delivery of the placenta was conducted in 6 centers with a total of 841 women participating in the study. As the predetermined termination indices for expulsions were exceded at 6 months, the trial was prematurely closed. An excess of expulsions during the first 48 hours following insertion was observed for the Lippes Loop compared to the other devices. At 6 months the expulsion rate for the Lippes Loop was significantly higher than that for the Copper 7. There were no significant differences in either the expulsion rates or the discontinuation rate at 6 or 12 months between the Postpartum T and the other devices. At 12 months the pregnancy rates with all 3 devices were high; there were no ectopic pregnancies. Considerable between-center differences were observed, particularly for expulsion rates. Possible reasons for this are discussed and future research lines are suggested.

journal_name

Contraception

journal_title

Contraception

authors

doi

10.1016/0010-7824(80)90112-2

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

9-18

issue

1

eissn

0010-7824

issn

1879-0518

pii

0010-7824(80)90112-2

journal_volume

22

pub_type

临床试验,杂志文章,随机对照试验

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