Abstract:
:A simple survey was made of health-care providers to determine their attitudes toward oral contraceptives containing more than 50 mcg of estrogen. It was found that about two-thirds of respondents prescribe this group of medication, although few do so regularly. Their use seemed correlated with providers 40 years of age or older. Even members of an association of professionals interested in contraception frequently used these pills. Although this group of contraceptives is being phased out, it is felt that professionals should have ceased their use long ago. :A simple survey was made of health-care providers in the US to determine their attitudes toward oral contraceptives containing 50 mcg of estrogen. 3 groups were surveyed by mail: 100 gynecologists (2 from each state) chosen from the Directory of Fellows of the American College of Obstetricians and Gynecologists, 100 family practitioners selected from the American Academy of Family Physicians Membership Directory, and 81 members of the Association of Reproductive Health Professionals (50 gynecologists, 25 family practitioners, 6 nurse practitioners). It was found that about 2/3 (61%) of respondents prescribe this group of medication, although few do so regularly. Their use seemed correlated with providers 50 years of age or older. Even members of the association of professionals interested in contraception frequently used these pills (very few members were under 40 years of age). Although this group of contraceptives is being phased out, it is felt that professionals should have ceased their use long ago due to their high risk compared to low-estogen pills. Even though a majority of practitioners precribe high-estrogen pills, very few feel that they are essential. However, 10% responded that it would be a problem if all of these products were taken off the market.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Grossman RAdoi
10.1016/0010-7824(88)90159-xsubject
Has Abstractpub_date
1988-11-01 00:00:00pages
561-5issue
5eissn
0010-7824issn
1879-0518pii
0010-7824(88)90159-Xjournal_volume
38pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract:OBJECTIVES:In the United States, the popularity of intrauterine devices (IUDs) is low despite many positive attributes such as high effectiveness and ease of use. The requirement that a clinician remove the IUD may limit US women's interest in the method. Our objective was to describe women's experience with self-remov...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.01.025
更新日期:2014-07-01 00:00:00
abstract::Seventy women with prolactinomas, age 19-38 years, were studied in order to evaluate a possible relationship between the use of steroidal oral contraceptives (o.c.) and the development of prolactin-producing adenomas. Sixty-seven patients were admitted for investigation because of menstrual bleeding disturbances and t...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90057-4
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Provision of contraception is often linked with physical examination, including clinical breast examination (CBE) and pelvic examination. This review was conducted to evaluate the evidence regarding outcomes among women with and without physical examination prior to initiating hormonal contraceptives. STUDY...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2012.08.010
更新日期:2013-05-01 00:00:00
abstract::Gossypol, a polyphenolic pigment found in cotton plants, has been implicated as an antifertility agent. This pigment has been shown to alter myriad metabolic pathways. The objective of this study was to determine the effect of gossypol acetic acid on the hepatic microsomal drug metabolizing enzyme system in adult fema...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(90)90009-k
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the pharmacokinetic and pharmacodynamic effects of two novel levonorgestrel (LNG)-only contraceptive patches. STUDY DESIGN:This multi-center Phase I/II trial randomized participants to use a 7-day transdermal patch designed to deliver a 40 mcg or 75 mcg daily LNG dose for 11 consecutive weeks; r...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.04.007
更新日期:2018-04-18 00:00:00
abstract:OBJECTIVES:To assess factors associated with pregnancy fatalism among U.S. adult women. STUDY DESIGN:I used data from the Change and Consistency in Contraceptive Use study, which collected information from a national sample of 4634 U.S. women aged 18-39 at baseline (59% response rate). I assessed pregnancy fatalism ba...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.05.015
更新日期:2018-10-01 00:00:00
abstract::Researchers, health care providers, women's health advocates, donors, and representatives of ministries of health convened in Bellagio, Italy, in July 1998, to assess the potential of medical methods of early pregnancy termination to improve the reproductive health of women in developing countries. Consensus was reac...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(98)00109-7
更新日期:1998-11-01 00:00:00
abstract::Comparative phase I clinical trials were carried out in 5 centres with three formulations of beta-hCG-based vaccines inducing antibodies against human chorionic gonadotropin. The objectives of these trials were to determine their relative immunogenicity, duration, reversibility and safety. A total of 116 tubal ligated...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0010-7824(90)90071-3
更新日期:1990-03-01 00:00:00
abstract::Written guidelines for the preclinical testing of contraceptive steroids have not been revised since 1968 despite the fact that many important changes have been implemented by the FDA's Division of Metabolism and Endocrine Drug Products. This paper describes the new preclinical testing requirements and the rationale f...
journal_title:Contraception
pub_type: 指南,杂志文章
doi:10.1016/0010-7824(92)90114-9
更新日期:1992-12-01 00:00:00
abstract::In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (Marvelon) on variables of carbohydrate metabolism by means of or...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(02)00537-1
更新日期:2003-06-01 00:00:00
abstract::The uterine sound length, the functional length of the cervix including the zone of internal cervical os and the fundus transversal were determined in 795 fertile women in vivo using a measuring device, the Cavimeter. The functional cavity length was calculated by subtracting the functional length of the cervix from t...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(84)80011-6
更新日期:1984-06-01 00:00:00
abstract::The use of mifepristone as an anti-implantation agent in the primate has been explored in the rhesus monkey with two specific aims: (i) to determine the contraceptive efficacy of very low-dose mifepristone administered on mated cycle days 16, 17, and 18; and (ii) to test the hypothesis that alteration in endometrial p...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(96)00280-6
更新日期:1997-02-01 00:00:00
abstract::A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90038-0
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:This study was conducted to assess the efficacy and incidence of side effects of a regimen of repeated doses of 400 microg sublingual misoprostol for termination of pregnancy of <7 weeks gestation. METHOD:Fifty women were given 400 microg sublingual misoprostol every 3 h for three doses. Two additional dose...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(03)00134-3
更新日期:2003-08-01 00:00:00
abstract::The ability of 40 mg of milled suspension of a new long-acting androgen ester (20 Aet-1) to restore and maintain accessory gland function was compared with that of testosterone enanthate (TE) in castrated adult rhesus monkeys. Castration did not abolish the ejaculatory response since only two animals did not void seme...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(91)90129-4
更新日期:1991-01-01 00:00:00
abstract::The potent luteinizing hormone-releasing hormone (LRH) agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 or 25 microgram for 1, 3 or 5 consecutive days to twelve regularly menstruating women in the early follicular phase of the menstrual cycle in an attempt to disturb follicular maturatio...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(82)90016-6
更新日期:1982-01-01 00:00:00
abstract::Conventional oral contraceptive (OC) starting instructions require waiting until menses to begin the OC. The conventional approach requires detailed patient education about when to begin and also may require the use of less effective or less acceptable interim contraceptive protection until menses. At our urban family...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00351-7
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Music has served as an auxiliary analgesic in perioperative settings. This study evaluates the impact of intraoperative music added to routine pain control measures during first trimester surgical abortion. STUDY DESIGN:We analyzed data from 101 women randomized to undergo abortion with routine pain control...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2011.11.017
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:In levonorgestrel intrauterine system (LNG-IUS) users, the prevention of sperm penetration through cervical mucus has not been demonstrated. STUDY DESIGN:Subjects were enrolled in an investigator-blinded study to compare quality and sperm penetrability of mid-cycle cervical mucus between LNG-IUS users and h...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2010.06.006
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:This study compared adherence to follow-up and clinical outcomes between standard in-clinic and remote follow-up after methotrexate/misoprostol abortion. STUDY DESIGN:This nonrandomized trial recruited women requesting medical abortion at two sexual health clinics in Toronto, Canada. Women received methotrex...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2015.05.013
更新日期:2015-09-01 00:00:00
abstract::Biochemical studies with a once-a-month contraceptive pill containing 2 mg quinestrol and 2.5 mg quingestanol acetate were undertaken during a period of 24 months. The 1st pill was given on the 2nd day of the menstrual cycle and the 2nd on the 22nd day of the same cycle; thereafter the pills were given every 28th day...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(75)90065-7
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasoni...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2009.12.001
更新日期:2010-04-01 00:00:00
abstract::The mechanism of action of intrauterine devices varies from one type of device to another, although the principle of action is the same, namely, to interfere with the physiology of reproduction at the endometrial level. The biochemical changes of the endometrial tissue and the composition of the uterine fluid have bee...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(87)90058-8
更新日期:1987-07-01 00:00:00
abstract::The effect of cupric ions on the uptake of tritiated-thymidine and 5-tritiated-uridine into endometrial cells obtained from pseudopregnant rabbits was studied in vitro. In endometrial cells obtained 48 and 120 hours after human chorionic gonadotropin injection, the uptake of tritiated-thymidine was significantly inhi...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(75)90076-1
更新日期:1975-10-01 00:00:00
abstract::The separate effect of ethinylestradiol (4 micrograms/kg b.w./day) and d-norgestrel (20 micrograms/kg b.w./day) on the fibrinolytic activity in plasma and in vessel walls of the hind leg was investigated in an experimental study on rats. No hormonal effect on the fibrinolytic activity in plasma was registered. However...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(84)90101-x
更新日期:1984-08-01 00:00:00
abstract::The purpose of the study was to evaluate semen quality in young Chinese men and to establish reference values. Normal healthy young men from seven geographical areas were enrolled. The study showed that the mean sperm volume was 2.61 mL, and mean percent of sperm with forward progression was 59.89, while median of sem...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00281-0
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To assess the safety profile of the low-dose levonorgestrel intrauterine system (LNG-IUS) total content 13.5mg (average approximate release rate 8μg/24h over the first year; LNG-IUS 8; Jaydess®) in adolescents. STUDY DESIGN:In a Phase III study in 36 European centers, 304 healthy nulliparous or parous postme...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/j.contraception.2016.02.004
更新日期:2016-06-01 00:00:00
abstract::STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone ad...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90140-7
更新日期:1980-01-01 00:00:00
abstract::In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (EE + DRSP = Yasmin), with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (EE + DSG = Marvelon) on the lipid profile. The prim...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.contraception.2003.11.003
更新日期:2004-04-01 00:00:00
abstract::RU 486 and three of its metabolites (RU 42633-monodemethyl, RU 42848-didemethyl, and RU 42698-hydroxymetabolite) were determined by HPLC in plasma from nine non-pregnant and 36 pregnant women. Each non-pregnant subject took an oral dose of RU 486 (25, 100, 400 and 600 mg consecutively) once per menstrual cycle. Six of...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90004-q
更新日期:1993-08-01 00:00:00