Abstract:
:Data from published studies of the quantity of medroxyprogesterone acetate and/or its metabolites in the milk of lactating women receiving Depo-Provera for contraception is extrapolated into the amount of drug ingested daily by a theoretically average infant. Comparisons are made with the results of similar studies in animals. Fetal metabolism of medroxyprogesterone acetate is reviewed. Embryonic and fetal development of the human reproductive system is discussed. Results of studies of the effects of steroidal hormones, particularly medroxyprogesterone acetate, on mental development and sexual dimorphic behavior after exposure in utero are presented. It is concluded that the very small amount of drug and/or its metabolites ingested by the nursing infant via breast milk is highly unlikely to have any significant effect on the nursing infant.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Schwallie PCdoi
10.1016/0010-7824(81)90027-5subject
Has Abstractpub_date
1981-04-01 00:00:00pages
375-86issue
4eissn
0010-7824issn
1879-0518pii
0010-7824(81)90027-5journal_volume
23pub_type
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