Effect of dose on the pharmacokinetics of levonorgestrel in the rat during the rapid elimination phase following subcutaneous administration.

abstract：:This investigation describes the synthesis of a biodegradable hydrogel composed of a core surrounded by four concentric sheaths containing dextran, copolymers of polylactide and epsilon-caprolactone. The hydrogel was impregnated with iron (II) d-gluconate dihydrate, which causes complete spermiostasis due to lipid per...

journal_title：Contraception

authors： Saxena BB,Singh M,Gospin RM,Chu CC,Ledger WJ

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:The Affordable Care Act (ACA) will expand health care coverage to low-income Americans. Contraception services are a mandated component of ACA plans. STUDY DESIGN:A decision-analytic model was developed to compare the costs and outcomes of the current versus the proposed plan for contraceptive coverage (Fed...

journal_title：Contraception

authors： Burlone S,Edelman AB,Caughey AB,Trussell J,Dantas S,Rodriguez MI

更新日期：2013-02-01 00:00:00

abstract：:A prospective randomized trial was conducted in 140 women to compare the efficacy of vaginal gemeprost with vaginal misoprostol for termination of second trimester pregnancy. Women requesting termination of second trimester pregnancy were randomized into two groups. Group A women were given 1 mg vaginal gemeprost ever...

journal_title：Contraception

authors： Wong KS,Ngai CS,Wong AY,Tang LC,Ho PC

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...

journal_title：Contraception

authors： Uhm S,Garcia-Ruiz N,Creinin MD,Blanton A,Chen MJ

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To describe clinical outcomes of etonogestrel implant patients with migration to the vasculature, chest wall and other distant body sites spontaneously reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. STUDY DESIGN:We performed a standardized Medical Dictionary ...

journal_title：Contraception

authors： Kang S,Niak A,Gada N,Brinker A,Jones SC

更新日期：2017-12-01 00:00:00

abstract：:A prospective, randomized clinical trial observed the effects of Norplant long-term contraceptive implants and domestic implants similar to Norplant on bone mineral density and bone metabolism in female acceptors for 1 year. Bone mineral density (BMD) and bone mineral content (BMC) of lumbar 2-4 and proximal femur of ...

journal_title：Contraception

authors： Di X,Li Y,Zhang C,Jiang J,Gu S

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:Our objective was to explore knowledge, attitudes and beliefs about pregnancy and contraceptive decision-making among reproductive-aged women with cystic fibrosis. STUDY DESIGN:In this qualitative study, we used purposive sampling of reproductive age women enrolled in the Adult Cystic Fibrosis program at Pen...

journal_title：Contraception

authors： Traxler SA,Chavez V,Hadjiliadis D,Shea JA,Mollen C,Schreiber CA

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:The risk of pregnancy is estimated to be 20 times as high among women who use oral contraception, and 90 times as high among condom users, as among women who use certain long-acting contraceptive methods. We explored the population-level implications of this variation in contraceptive efficacy. STUDY DESIGN...

journal_title：Contraception

authors： Thomas A,Karpilow Q

更新日期：2016-08-01 00:00:00

abstract：:This study examines contraceptive delivery characteristics and their association with contraceptive behavior. Data were collected in telephone interviews from a national sample of 1057 women who were using female contraceptives. The overwhelming majority of the sample obtained contraceptive services from gynecologists...

journal_title：Contraception

authors： Harvey SM,Beckman LJ,Murray J

更新日期：1989-12-01 00:00:00

abstract：:A polymeric controlled release vaginal delivery system was developed for 15(S)15-methyl PGF2 alpha methyl ester. This delivery system is a reservoir-type device consisting of laminated membranes that are mounted on an inert holder. The delivery systems were designed to have in vitro steady-state release rates of 50 or...

journal_title：Contraception

authors： Bygdeman M,Christenssen N,Gréen K,Vesterqvist O,Roseman TJ,Tuttle ME,Spilman CH

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the initial safety and effectiveness of the intrauterine ball (IUB), a copper intrauterine device that, upon insertion in the uterus, takes a three-dimensional spherical form. STUDY DESIGN:Fifteen women were followed for 1 year, with follow-up visits at 1, 3, 6, 9 and 12 months. RESULTS:The phys...

journal_title：Contraception

authors： Baram I,Weinstein A,Trussell J

更新日期：2014-02-01 00:00:00

abstract：:High speed cinematography of latex condoms inflated to burst under standard (ISO) conditions reveals that rupture of the condom typically is initiated at a small focal point on the shank of the condom and then rapidly propagates throughout the condom's surface, often ending with partial or full severance of the condom...

journal_title：Contraception

authors： Stube R,Voeller B,Davidhazy A

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Globally, 14.3% of women of reproductive age use intrauterine contraception (IUC), but the distribution of IUC users is strikingly nonuniform. In some countries, the percentage of women using IUC is <2%, whereas in other countries, it is >40%. Reasons for this large variation are not well documented. The aim...

journal_title：Contraception

authors： Buhling KJ,Zite NB,Lotke P,Black K,INTRA Writing Group.

更新日期：2014-03-01 00:00:00

abstract：:The objective of this study was to describe the availability of early surgical and medical abortion among members of the National Abortion Federation (NAF) and to identify factors affecting the integration of early abortion services into current services. Telephone interviews were conducted with staff at 113 Planned P...

journal_title：Contraception

authors： Benson J,Clark KA,Gerhardt A,Randall L,Dudley S

更新日期：2003-04-01 00:00:00

abstract：:The potential use of tamoxifen, a nonsteroidal antiestrogen, as an antifertility agent was studied in the long-tailed macaque (Macaca fascicularis). Twenty-six cycling females were bred, then treated with a single oral dose of tamoxifen (5 mg/kg) (N = 13) or vehicle (N = 13) on day 4 post-ovulation. Serum progesterone...

journal_title：Contraception

authors： Tarantal AF,Hendrickx AG,Matlin SA,Lasley BL,Gu QQ,Thomas CA,Vince PM,Van Look PF

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:It can prove challenging to create social marketing materials aimed at a specific subsection of the population, especially when the topic is relatively new and possibly misunderstood. Therefore, the objective of this study was to assess adolescent knowledge of and attitudes towards emergency contraception (E...

journal_title：Contraception

authors： Johnson R,Nshom M,Nye AM,Cohall AT

更新日期：2010-02-01 00:00:00

abstract：:Although weight gain is among the most common complaints of women using oral contraceptives (OC) and a frequent reason for discontinuation, studies demonstrate little basis for this perception. We explored this issue by analyzing the daily weights of 128 women during four cycles of triphasic OC use. The mean weight at...

journal_title：Contraception

authors： Rosenberg M

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Postplacental intrauterine device (IUD) insertion is a safe, convenient and effective option for postpartum contraception. Few studies involve ultrasound-guided insertion, and none involve the levonorgestrel IUD or take place in the United States. STUDY DESIGN:The study was conducted to assess the safety an...

journal_title：Contraception

authors： Hayes JL,Cwiak C,Goedken P,Zieman M

更新日期：2007-10-01 00:00:00

abstract：:First year results of a randomized study of 1509 users of the Copper T380Ag with a silver core or of an IUD releasing 20 mcg day of levonorgestrel are reported. The cumulative gross pregnancy rate for each device was 0.3 per 100 at one year, with more than 490 women having one year of use with each device. The levonor...

journal_title：Contraception

authors： Sivin I,Alvarez F,Diaz J,Diaz S,el Mahgoub S,Coutinho E,Brache V,Diaz MM,Faundes A,Pavez M

更新日期：1984-11-01 00:00:00

abstract：:The effects of phenytoin treatment on plasma concentrations of norethisterone (NET) was studied in 7 healthy female rhesus monkeys. Before phenytoin treatment was started each monkey received an oral dose of 0.5 mg NET and 2 weeks later the same dose was given intravenously. On both occasions, plasma concentrations of...

journal_title：Contraception

authors： Barkfeldt JO,Odlind V,Victor A

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVES:The present study aims to prospectively evaluate quality of life (QoL) of women using 52-mg levonorgestrel intrauterine system (LNG-IUS) for contraception determined through the Sociedad Española de Contracepción (Spanish contraception Society) (SEC)-QoL, a questionnaire specifically designed to assess the i...

journal_title：Contraception

authors： Cristobal I,Lete LI,Viuda E,Perulero N,Arbat A,Canals I

更新日期：2016-04-01 00:00:00

abstract：:Medically induced abortion using a new regimen of oral mifepristone 600 mg and vaginal misoprostol 800 micrograms (PGE1 analogue) was carried out in 100 women. Abortion occurred in all patients without resort to surgery. In 99 women, the abortion occurred within 4 hours of the administration of the prostaglandin. Sixt...

journal_title：Contraception

authors： el-Refaey H,Templeton A

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:This study was aimed to evaluate a marketed mineralo-herbal preparation containing plants known to have potent contraceptive activity, or contraindicated for use during pregnancy in folklore/ancient Indian literature and recommended for use as an appetizer and headache, hyperacidity and chronic constipation r...

journal_title：Contraception

authors： Srivastava SR,Kesarwani S,Keshri G,Singh MM

更新日期：2005-12-01 00:00:00

abstract：:Sulprostone was given intramuscularly in two dose schedules of 0.5 mg at 4 hourly intervals for 8 doses and 1.0 mg at 8-hour intervals for 4 doses to 56 women in the 12th-20th week of gestation coming for termination of pregnancy. Forty-nine of them aborted within the 30-hour observation period, giving a success rate ...

journal_title：Contraception

authors： Ranjan V,Hingorani V,Kinra G,Agarwal N,Pande Y

更新日期：1982-02-01 00:00:00

abstract：:Eighty-four Chinese patients attending the Family Planning Association of Hong Kong for contraception with oral contraceptive pills were randomized into 2 groups. The first group received pills containing 0.15 mg levonorgestrel and 0.03 mg ethinyl oestradiol. The second group received pills containing 0.15 mg desogest...

journal_title：Contraception

authors： Ho PC,Liu WT,Kwan MS

更新日期：1990-01-01 00:00:00

abstract：:Mature rabbits received norethisterone-3-oxime (NETO) 2 mg/kg/day from day 2 through day 4 of pregnancy by gavage. Control rabbits were given vehicle. All animals were sacrificed on day 5. The oviducts were removed and sections stained with HE. Morphological changes were evaluated. The outer and inner diameters of tub...

journal_title：Contraception

authors： Li QG,Li DZ

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Surgical sterilization has many advantages. Previous information on prevalence and correlates was based on surveys of women. STUDY DESIGN:We estimated the prevalence of vasectomy and tubal ligation of partners for male participants in the 2002 National Survey of Family Growth, a nationally representative su...

journal_title：Contraception

authors： Anderson JE,Warner L,Jamieson DJ,Kissin DM,Nangia AK,Macaluso M

更新日期：2010-09-01 00:00:00

abstract：:A simple survey was made of health-care providers to determine their attitudes toward oral contraceptives containing more than 50 mcg of estrogen. It was found that about two-thirds of respondents prescribe this group of medication, although few do so regularly. Their use seemed correlated with providers 40 years of a...

journal_title：Contraception

authors： Grossman RA

更新日期：1988-11-01 00:00:00

abstract：:The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected...

journal_title：Contraception

authors： Takkar D,Jeyaseelan S,Kinra G,Laumas KR,Hingorani V

更新日期：1978-02-01 00:00:00

abstract：:Test agents were selected because of previous evidence of contragestationaal activity when administered systemically or because of known local effects which would be likely to cause endometrial changes having an adverse effect on pregnancy. A group of virgin female Sprague-Dawley rats were treated on Day 3 of pregnan...

journal_title：Contraception

authors： Conner EA,Blake DA,Parmley TH,Burnett LS,King TM

更新日期：1976-05-01 00:00:00