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Use of intra- and extra-amniotic prostaglandins for the termination of pregnancies--report of multicentric trial in India.

Abstract：

:The Indian Council of Medical Research initiated a multicentric trial with prostaglandins in 1976 to assess the safety and efficacy of their use in midtrimester abortions. PGF2 alpha and 15-Me-PGF2 alpha were compared using the intra-amniotic (I.A.) route. 15-Me-PGF2 alpha was also evaluated by extra-amniotic (E.A.) route. With intra-amniotic instillation, success rate was 88.1 per cent with PGF2 alpha and 93.0 per cent with 15-Me-PGF2 alpha within 48 hours and by the extra-amniotic route it was 78.1 per cent within 36 hours. The mean induction-abortion interval was 19 hours with I.A. and 14.8 hours with E.A. Abortions were complete in 48.8 per cent of the women following I.A. PGF2 alpha, 56.0 per cent following I.A. 15-Me-PGF2 alpha and only 23.0 per cent following E.A. administration. Vomiting and diarrhoea were the most commonly reported side effects. Cervical injuries were 4.7 per cent with I.A. PGF2 alpha, 1.4 per cent with I.A. 15-Me-PGF2 alpha and only 0.6 per cent with E.A. route.

journal_name

Contraception

journal_title

Contraception

authors

Tejuja S,Choudhury SD,Manchanda PK

doi

10.1016/0010-7824(78)90048-3

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

641-52

issue

6

eissn

0010-7824

issn

1879-0518

pii

0010-7824(78)90048-3

journal_volume

18

pub_type

临床试验,杂志文章,随机对照试验

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