Abstract：
:The aim of this study was to develop a mouse model to investigate the effects of long-term progestin-only exposure on endometrial vascular structure. Normal cycling mice received Silastic implants containing either medroxyprogesterone acetate (MPA) or levonorgestrel (LNG) and were dissected after 1, 3 or 6 weeks. Endometrial vascular density increased significantly within 1 week of MPA (482 +/- 40.2 vessels/mm2) or LNG (440 +/- 26.5 vessels/mm2) treatment compared with normal cycling mice (293 +/- 10.5 vessels/mm2). MPA increased stromal cell density within 1 week of treatment (13813 +/- 1450 cells/mm2) compared with normal cycling mice (8256 +/- 928 cells/mm2). However, although LNG significantly increased stromal cell density overall, the increase did not reach significance within the individual weeks examined. There was no significant change in the ratio of vascular to stromal cell density among treated and normal cycling mice. Epithelial cell height significantly decreased within 1 week of LNG (17.6 +/- 1.3 microm) treatment compared with normal cycling mice (23.5 +/- 1.3 microm); epithelial cell height also decreased within 1 week of MPA treatment (16.6 +/- 2.1 microm), although this did not reach statistical significance. VEGF immunostaining increased significantly in luminal epithelium after MPA or LNG treatment, and in glandular epithelium after LNG treatment. These observations are similar to those reported in human endometrium, suggesting that this mouse model may facilitate further investigations into breakthrough bleeding due to long-term progestin use.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Girling JE,Heryanto B,Patel N,Rogers PAdoi
10.1016/j.contraception.2004.04.006subject
Has Abstractpub_date
2004-10-01 00:00:00pages
343-50issue
4eissn
0010-7824issn
1879-0518pii
S0010782404001258journal_volume
70pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:A study was undertaken to determine if copper wire, placed within the uterine lumen after implantation and kept in situ throughout pregnancy, results in an excessive accumulation of the metal in maternal and/or fetal tissues; and if so, what effect if any, such an accumulation may have on both mother and offspring. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90060-2
更新日期：1974-05-01 00:00:00
abstract：OBJECTIVE:To evaluate pregnancy complication rates and related charges in users of 84/7, 21/7 and 24/4 combined oral contraceptives (COCs). STUDY DESIGN:Data were obtained from the i3 InVision Data Mart™ retrospective claims database. Subjects were aged 15-40 years, first prescribed a COC between 1/1/2006 and 4/1/2011...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.12.006
更新日期：2014-05-01 00:00:00
abstract：:Combination oral contraceptive (COC) users have reduced risks of ovarian and endometrial cancer, but COCs have not reduced breast cancer risk. We have previously argued that a hormonal contraceptive with substantially lower doses of sex-steroids should reduce breast cancer risk by decreasing the breast epithelial cell...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(93)90095-o
更新日期：1993-05-01 00:00:00
abstract：:One-hundred patients undergoing Falope ring or clip laparoscopic tubal ligation were given either a placebo or a 100 mg indomethacin rectal suppository one hour pre-operatively. Treatment was randomised and double-blind. Post-operative analgesic requirements and side effects were monitored. Forty-seven patients receiv...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(90)90018-q
更新日期：1990-09-01 00:00:00
abstract：:The purpose of this study was to investigate the efficacy and the acceptability of Prazosin as a male contraceptive pill. Acceptable antifertility drugs for men are proving difficult to produce, and the possibility of using pharmacological agents to block selectively or to inhibit normal sperm transport through the ma...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(88)90008-x
更新日期：1988-06-01 00:00:00
abstract：OBJECTIVE:This study aims to compare the cost-effectiveness of oral contraceptives (OCs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and surgical management in treating dysfunctional uterine bleeding (DUB) in women not desiring additional children. METHOD:A Markov model was constructed from the perspec...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2006.03.024
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:Assisting women with choosing contraceptive methods that meet their needs and preferences is essential to providing patient-centered care, but research to inform interventions supporting method choice is lacking. An assessment of patient decisional needs for contraceptive method choice may provide insight int...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.10.004
更新日期：2018-03-01 00:00:00
abstract：:Effect of RISUG, a newly developed male contraceptive, on various amino acids of seminal plasma ejaculates was studied by proton magnetic resonance spectroscopy at 400 MHz. Levels of amino acids were compared with the seminal plasma of obstructive azoospermia and controls. Glutamic acid, glutamine, and arginine were f...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00343-8
更新日期：2002-09-01 00:00:00
abstract：:20 patients underwent intraamniotic administration of PGF2alpha for termination of pregnancies ranging from 14-20 weeks gestation. Success was achieved in 18 patients (90%) with this method. The 2 failures were terminated vaginally with adjunctive use of intracervical laminaria and intravenous pitocin induction. 10...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90049-3
更新日期：1974-06-01 00:00:00
abstract：BACKGROUND:This study was conducted to compare breast epithelial-cell proliferation and estrogen and progesterone receptor levels in women taking one of two oral contraceptives (OCs) containing the same dose of estrogen but different doses of the progestin norethindrone (NET). STUDY DESIGN:Thirty-three women were rand...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2011.12.015
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:Our objective was to compare continuation and complication rates of subdermal etonogestrel implants and intrauterine devices (IUDs) using Medicaid insurance claims. STUDY DESIGN:We performed a retrospective cohort study using insurance claims data for 15- to 44-year-old subjects receiving implants or IUDs fr...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.04.012
更新日期：2018-04-24 00:00:00
abstract：:The morphology and the related composition of T-type intrauterine devices (IUDs) made of gold-plated copper were studied in relation to patient complaints. The removed IUDs were examined without pretreatment by scanning electron microscopy and energy dispersive x-ray spectroscopy. Besides the previously found incrusta...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2004.03.006
更新日期：2004-08-01 00:00:00
abstract：:Postpartum contraceptive decision making is complex, and recommendations may be influenced by breastfeeding intentions. While biologically plausible, concerns about the adverse impact of hormonal contraception on breast milk production have not been supported by the clinical evidence to date. However, the data have li...
journal_title：Contraception
pub_type： 社论
doi：10.1016/j.contraception.2018.10.011
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:This study estimates how making oral contraceptive pills (OCPs) available without a prescription may affect contraceptive use, unintended pregnancies and associated contraceptive and pregnancy costs among low-income women. STUDY DESIGN:Based on published figures, we estimate two scenarios [low over-the-count...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.01.010
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Intrauterine contraception (IUC) is safe, highly effective and has few medical contraindications. Primary care providers see many women with chronic conditions who might benefit from IUC. STUDY DESIGN:We surveyed women aged 18-50 who visited one of four primary care clinics in Pennsylvania between October 2...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.02.004
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:The relationship between the source of sexual information and adolescent sexual behavior is not well understood. MATERIALS AND METHODS:As part of a larger study, 892 sexually active female adolescents between 15 and 18 years of age completed a paper-and-pencil survey which assessed discussions about sexua...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2005.08.014
更新日期：2006-03-01 00:00:00
abstract：:The effect of consecutively injecting a one-a-month contraceptive (norethisterone enantate 50 mg with estradiol valerate 5 mg) for one year on haematological parameters was evaluated in 42 Chinese women. The healthy volunteers were randomly allocated to either the treatment group (22) or a control group (20). Blood sa...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(90)90052-w
更新日期：1990-10-01 00:00:00
abstract：:An estimate of the menstrual blood loss (MBL) in 29 women using the Cu-7 and in 33 women using the ML-250 IUDs was carried out. None of the women who took part in the study used hormonal contraceptives or IUDs for six months previous to the study. Before the insertion of the IUD, the MBL of each woman was measured for...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(82)90146-9
更新日期：1982-11-01 00:00:00
abstract：:Patterns of bleeding and plasma concentrations of levonorgestrel, progesterone, estradiol, LH and FSH were studied in ten volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. The IUD was designed to release 12 microgram/day. All but two of the volunteers ovulated during treatment. The ovulatory ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90127-4
更新日期：1980-02-01 00:00:00
abstract：:For women with a history of cervical insufficiency, treatment with transvaginal (TV) or abdominal (TA) cerclage is often recommended; however management of pregnancy complications necessitating uterine evacuation in the second trimester are challenging. We present a patient at 17 weeks 3 day gestation with preterm pre...
journal_title：Contraception
pub_type：
doi：10.1016/j.contraception.2020.01.013
更新日期：2020-05-01 00:00:00
abstract：:Neo Sampoon is an effervescent contraceptive vaginal tablet manufactured in Japan that contains 60 mg of the spermicide menfegol. Ortho Vaginal Tablets (OVT) and Emko Vaginal Tablets (EVT), both containing 100 mg of the spermicide nonoxynol-9, were manufactured in the USA. The three products were compared in a randomi...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(85)90015-0
更新日期：1985-11-01 00:00:00
abstract：:Deeply inserted, nonpalpable contraceptive implants can often be removed easily using 6-8 cm3 of 1% lidocaine and a single 1 cm incision. There is no need for suturing of the incision. The location of nonpalpable implants not retrieved by this procedure can be determined by a plain, soft tissue x-ray (standard AP and ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(96)00004-2
更新日期：1996-03-01 00:00:00
abstract：:The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(78)90066-5
更新日期：1978-02-01 00:00:00
abstract：:This report combines the data obtained in three multicenter efficacy studies with a new triphasic oral contraceptive combination containing desogestrel (DSG) and ethinyl estradiol (EE). The studies were conducted at 40 investigational sites in the United States (38 centers) and Canada (2 centers) in support of the FDA...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0010-7824(93)90078-l
更新日期：1993-10-01 00:00:00
abstract：:The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(89)90012-7
更新日期：1989-01-01 00:00:00
abstract：:RU 486, a new antiprogestational compound, was given to 37 women seeking termination of pregnancy and with amenorrhea of 42 days or less. One patient was found at the second follow-up visit to have an extrauterine pregnancy. The patients received either 25 mg, 50 mg or 100 mg RU 486 twice daily for four days. All pati...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(84)90014-3
更新日期：1984-05-01 00:00:00
abstract：:Ethylene-vinyl acetate (EVA) polymeric contraceptive implants (Implanon) containing 3-keto-desogestrel have been prepared aiming at an in vitro initial release rate of 60 micrograms 3-keto-desogestrel/day. These implants are designed to have an intended life-time of 2 years. During a 3-year period, the release of thes...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(93)90093-m
更新日期：1993-02-01 00:00:00
abstract：BACKGROUND:This study analyzes levels of progesterone, estradiol, norethindrone (NET) and ethinyl estradiol (EE) in serum and levels of NET in cervical mucus on the last day of the hormone-free interval (HFI) in users of 24/4 [norethindrone acetate (NETA)/EE-24] vs. 21/7 (NETA/EE-21) regimens. STUDY DESIGN:This was a ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.contraception.2012.12.006
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To assess the contraceptive performance of the 52-mg 20 μg/day levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena; Bayer Oy, Turku, Finland) among women who maintain the same device without changes after 60 months. STUDY DESIGN:This is a chart review study in which we assessed the charts of 766 wo...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.10.007
更新日期：2018-03-01 00:00:00
abstract：:To compare the effectiveness and safety of the Filshie Clip System and Hulka Clip System when applied via minilaparotomy and laparoscopy, we conducted 2 multicenter randomized controlled trials of 2126 women (878 in the minilaparotomy study and 1248 in the laparoscopy study) who received either the Filshie or Hulka Cl...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(00)00166-9
更新日期：2000-10-01 00:00:00
