Abstract：
:The metabolic and hemostatic effects of two oral contraceptives containing 150 mcg desogestrel and 20 mcg ethinyl-estradiol (EE) (MERCILON) or 30 mcg EE (MARVELON) were compared in order to examine the effect of reducing the EE dose in contraceptive pills. Forty-nine women participated in this randomized study during 6 cycles. In both groups, there was a significant increase in triglycerides, HDL-cholesterol and apoprotein A1; the same increase was observed for SBP and CBG. Slight and transient variations of fasting blood glucose levels were seen in the 30 mcg EE group and in the two groups for fasting insulin levels. The increase in renin substrate was significantly higher with the 30 mcg EE than with the 20 mcg EE pill. In both groups, plasminogen increased significantly, but antithrombin III, total and free protein S and fibrinogen decreased significantly only in women taking the 30 mcg EE pill, whereas there was no significant change in the 20 mcg EE group. Reducing the dose of EE in oral contraceptives from 30 mcg to 20 mcg minimizes their impact on renin substrate and hemostatic parameters.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Basdevant A,Conard J,Pelissier C,Guyene TT,Lapousterle C,Mayer M,Guy-Grand B,Degrelle Hdoi
10.1016/0010-7824(93)90141-ssubject
Has Abstractpub_date
1993-09-01 00:00:00pages
193-204issue
3eissn
0010-7824issn
1879-0518pii
0010-7824(93)90141-Sjournal_volume
48pub_type
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