Laboratory exercises to teach clinically relevant chemistry of antibiotics.

Abstract:

OBJECTIVES:To design, implement, and evaluate student performance on clinically relevant chemical and spectral laboratory exercises on antibiotics. DESIGN:In the first of 2 exercises, second-year pharmacy students enrolled in an integrated laboratory sequence course studied the aqueous stability of ß-lactam antibiotics using a spectral visual approach. In a second exercise, students studied the tendency of tetracycline, rifamycins, and fluoroquinolones to form insoluble chelate complexes (turbidity) with polyvalent metals. ASSESSMENT:On a survey to assess achievement of class learning objectives, students agreed the laboratory activities helped them better retain important information concerning antibiotic stability and interactions. A significant improvement was observed in performance on examination questions related to the laboratory topics for 2012 and 2013 students compared to 2011 students who did not complete the laboratory. A 1-year follow-up examination question administered in a separate course showed >75% of the students were able to identify rifamycins-food interactions compared with <25% of students who had not completed the laboratory exercises. CONCLUSION:The use of spectral visual approaches allowed students to investigate antibiotic stability and interactions, thus reinforcing the clinical relevance of medicinal chemistry. Students' performance on questions at the 1-year follow-up suggested increased retention of the concepts learned as a result of completing the exercises.

journal_name

Am J Pharm Educ

authors

El Sayed KA,Chelette CT

doi

10.5688/ajpe78237

subject

Has Abstract

pub_date

2014-03-12 00:00:00

pages

37

issue

2

eissn

0002-9459

issn

1553-6467

pii

ajpe37

journal_volume

78

pub_type

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