The relationship between borderline personality disorder and bipolar disorder.

Abstract:

:It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We reviewed the most studied question on the relationship between BPD and bipolar disorder: their diagnostic concordance. Across studies, approximately 10% of patients with BPD had bipolar I disorder and another 10% had bipolar II disorder. Likewise, approximately 20% of bipolar II patients were diagnosed with BPD, though only 10% of bipolar I patients were diagnosed with BPD. While the comorbidity rates are substantial, each disorder is nontheless diagnosed in the absence of the other in the vast majority of cases (80% to 90%). In studies examining personality disorders broadly, other personality disorders were more commonly diagnosed in bipolar patients than was BPD. Likewise, the converse is also true: other axis I disorders such as major depression, substance abuse, and post-traumatic stress disorder are also more commonly diagnosed in patients with BPD than is bipolar disorder. These findings challenge the notion that BPD is part of the bipolar spectrum. :En los pacientes que buscan un tratamiento para la depresíón es importante, clínicamente, reconocer tanto el trastorno bipolar como el trastorno de personalidad borderline (TPB) y es primordíal poder distinguirlos. Las investigaciones que consideran que el TPB debe ser íncluido como parte del espectro bípolar llegan a distintas conclusiones. Se revisó la pregunta más estudiada acerca de la relación entre el TPB y el trastorno bipolar: ¿cuál es su concordancía diagnóstica? Entre los estudíos se encontró que aproxímadamente el 10% de los pacientes con TPB tenía un trastorno bipolar I y otro 10% tenía un trastorno bipolar II. Asimismo, aproxímadamente el 20% de los pacíentes bípolares II fue diagnostícado con TPB, en cambio sólo el 10% de los bípolares I tuvo ese díagnóstico. A pesar de que las cifras de comorbilidad son considerables, cada trastorno es díagnostícado en ausencía del otro en la gran mayoría de los casos (80% a 90%). En los estudios que examínan en general los trastornos de personalidad, los pacientes bipolares fueron díagnostícados más comúnmente con otros trastornos de la personalidad que con el TPB. Asimismo, lo inverso también es verdadero: otros trastornos del eje I como la depresión mayor, el abuso de sustancías y el trastorno por estrés postraumático también fueron díagnostícados con mayor frecuencia en pacientes con TPB que en el trastorno bípolar. Estos hallazgos ponen en tela de juícío la idea que el TPB es parte del espectro bípolar. :Il est important de reconnaître cliniquement le trouble bipolaire et la personnalité « borderline » (PBL) chez les patients demandant un traitement antidépresseur, et de les distinguer l'un de l'autre. Pour la recherche, l'appartenance de la PBL au cadre des troubles bipolaires a donné lieu à des conclusions divergentes. Nous analysons la question la plus étudiée sur la relation entre la PBL et le trouble bipolaire: leur concordance diagnostique. Dans les études, environ 10% des patients ayant une PBL sont atteints de trouble bipolaire 1 et 10% de trouble bipolaire II. De même, environ 20% des patients bipolaires II souffrent de PBL alors que seulement 10% des patients bipolaires I ont une PBL. Les taux de comorbidité sont importants mais chaque maladie est néanmoins diagnostiquée en l'absence de l'autre dans la grande majorité des cas (80 à 90%). Dans les études s'intéressant aux troubles de la personnalité de manière plus large, les autres troubles de la personnalité ont été plus fréquemment diagnostiqués chez les patients bipolaires. L'inverse est également vrai: les autres troubles de l'axe I comme la dépression majeure, les abus de substance et les états de stress post-traumatique sont plus fréquemment rencontrés chez les patients PBL que chez les patients bipolaires. Ces résultats remettent en question la notion de l'appartenance de la PBL au cadre bipolaire.

authors

Zimmerman M,Morgan TA

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

155-69

issue

2

eissn

1294-8322

issn

1958-5969

journal_volume

15

pub_type

杂志文章,评审
  • The role of circadian clock genes in mental disorders.

    abstract::The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders. Sleep distu...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Lamont EW,Legault-Coutu D,Cermakian N,Boivin DB

    更新日期:2007-01-01 00:00:00

  • Functional neuroimaging and schizophrenia: a view towards effective connectivity modeling and polygenic risk.

    abstract::We review critical trends in imaging genetics as applied to schizophrenia research, and then discuss some future directions of the field. A plethora of imaging genetics studies have investigated the impact of genetic variation on brain function, since the paradigm of a neuroimaging intermediate phenotype for schizophr...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Birnbaum R,Weinberger DR

    更新日期:2013-09-01 00:00:00

  • Alternative and complementary approaches in psychiatry: beliefs versus evidence.

    abstract::While the legitimacy of medical treatments is more and more questioned, one sees a paradoxical increase in nonconventional approaches, notably so in psychiatry. Over time, approaches that were considered valuable by the scientific community were found to be inefficacious, while other approaches, labelled as alternativ...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Schulz P,Hede V

    更新日期:2018-09-01 00:00:00

  • Outpatient Long-term Intensive Therapy for Alcoholics (OLITA): a successful biopsychosocial approach to the treatment of alcoholism.

    abstract::Alcohol dependence is a frequent, chronic, relapsing, and incurable disease with enormous societal costs. Thus, alcoholism therapy and research into its outcome are of major importance for public health. The present article will: (i) give a brief overview of the epidemiology, pathogenesis, and treatment outcomes of al...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:

    authors: Krampe H,Stawicki S,Hoehe MR,Ehrenreich H

    更新日期:2007-01-01 00:00:00

  • Common genetic risk factors for psychiatric and simatic disorders.

    abstract::There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidat...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:

    authors: Bondy B

    更新日期:2003-06-01 00:00:00

  • Autism and talent: the cognitive and neural basis of systemizing.

    abstract::In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with ...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Baron-Cohen S,Lombardo MV

    更新日期:2017-12-01 00:00:00

  • An overview of inborn errors of metabolism affecting the brain: from neurodevelopment to neurodegenerative disorders.

    abstract::Inborn errors of metabolism (IEMs) are particularly frequent as diseases of the nervous system. In the pediatric neurologic presentations of IEMs neurodevelopment is constantly disturbed and in fact, as far as biochemistry is involved, any kind of monogenic disease can become an IEM. Clinical features are very diverse...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Saudubray JM,Garcia-Cazorla A

    更新日期:2018-12-01 00:00:00

  • Lifelong posttraumatic stress disorder: evidence from aging Holocaust survivors.

    abstract::Despite the fact that 50 years have passed since the Nazi regime and the Holocaust the psychic sequelae are far from being overcome. The majority of Holocaust survivors and World War II veterans still list their experiences as the "most significant stressors" of their lives. The literature provides ample evidence that...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:

    authors: Barak Y,Szor H

    更新日期:2000-03-01 00:00:00

  • Core symptoms of major depressive disorder: relevance to diagnosis and treatment.

    abstract::The construct of major depressive disorder makes no etiological assumptions about populations with diverse symptom clusters. "Depressed mood" and "loss of interest or pleasure in nearly all activities" are core features of major depressive episode, though a strong case can be made to pay increasing attention to sympto...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Kennedy SH

    更新日期:2008-01-01 00:00:00

  • Pharmacological models in Alzheimer's disease research.

    abstract::Wider use of pharmacological models would facilitate the development of new drugs for Alzheimer's disease (AD), The two main models currently used are based on the cholinergic and glutamatergic hypotheses of AD, Although they lead to some of the attention and memory impairment observed in AD, they do not fully reprodu...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:

    authors: Gilles C,Ertlé S

    更新日期:2000-09-01 00:00:00

  • Harnessing the microbiota to treat neurological diseases
.

    abstract::Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota-the collection of commensal organisms that live in and on each of us-contributes ...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Surana NK

    更新日期:2019-01-01 00:00:00

  • Cellular basis of memory for addiction.

    abstract::DESPITE THE IMPORTANCE OF NUMEROUS PSYCHOSOCIAL FACTORS, AT ITS CORE, DRUG ADDICTION INVOLVES A BIOLOGICAL PROCESS: the ability of repeated exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and loss of control over drug use, that define a state o...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Nestler EJ

    更新日期:2013-12-01 00:00:00

  • The impact of the digital revolution 
on human brain and behavior: where 
do we stand?
.

    abstract::This overview will outline the current results of neuroscience research on the possible effects of digital media use on the human brain, cognition, and behavior. This is of importance due to the significant amount of time that individuals spend using digital media. Despite several positive aspects of digital media, wh...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:10.31887/DCNS.2020.22.2/mkorte

    authors: Korte M

    更新日期:2020-06-01 00:00:00

  • Descriptive psychopathology, phenomenology, and the legacy of Karl Jaspers.

    abstract::With his early publications (1910-1913), Karl Jaspers created a comprehensive methodological arsenal for psychiatry, thus laying the foundation for descriptive psychopathology. Following Edmund Husserl, the founder of philosophical phenomenology, Jaspers introduced phenomenology into psychopathology as "static underst...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Häfner H

    更新日期:2015-03-01 00:00:00

  • Emotor control: computations underlying bodily resource allocation, emotions, and confidence.

    abstract::Emotional processes are central to behavior, yet their deeply subjective nature has been a challenge for neuroscientific study as well as for psychiatric diagnosis. Here we explore the relationships between subjective feelings and their underlying brain circuits from a computational perspective. We apply recent insigh...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Kepecs A,Mensh BD

    更新日期:2015-12-01 00:00:00

  • Serotonergic and noradrenergic function in depression: clinical correlates.

    abstract::The present study was conducted in order to investigate the relationships between central noradrenergic (NA) and serotonergic (5-HT) function and clinical characteristics of a major depressive episode according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. We measured growth hormone res...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:

    authors: Duval F,Mokrani MC,Bailey P,Corrêa H,Crocq MA,Son Diep T,Macher JP

    更新日期:2000-09-01 00:00:00

  • A brief review of the genetics and pharmacogenetics of opioid use disorders.

    abstract::Increased physician prescribing of opioids to treat chronic nonprogressive pain has been accompanied by an increase in opioid addiction. Twin studies of opioid addiction are consistent with an inherited component of risk, approximately 50%. Several genome-wide association study (GWAS) reports indicate that genetic ris...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Berrettini W

    更新日期:2017-09-01 00:00:00

  • Personalized medicine in psychiatry: ethical challenges and opportunities.

    abstract::Pharmacogenomic developments hold promise for personalized medicine in psychiatry with adjusted therapeutic doses, predictable responses, reduced adverse drug reactions, early diagnosis, and personal health planning. The prospects are exciting, but at the same time, these new techniques stand faced with important scie...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Evers K

    更新日期:2009-01-01 00:00:00

  • Applications of magnetic resonance imaging for treatment-resistant late-life depression.

    abstract::Late-life depression (LLD) is a growing public and global health concern with diverse clinical manifestations and etiology. This literature review summarizes neuroimaging findings associated with depression in older adults and treatment-response variability. LLD has been associated with cerebral atrophy, diminished my...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Agudelo C,Aizenstein HJ,Karp JF,Reynolds CF 3rd

    更新日期:2015-06-01 00:00:00

  • Nonpharmacological treatment of dyscognition in schizophrenia: effects 
of aerobic exercise
.

    abstract::Cognitive symptoms are a core feature of schizophrenia and are related to an unfavorable disease outcome. So far, there are no satisfactory pharmacological approaches to address cognitive symptoms. For some time now, aerobic exercise has been demonstrated in various trials to be a promising candidate for this indicati...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,meta分析,评审

    doi:10.31887/DCNS.2019.21.3/aschmitt

    authors: Maurus I,Röh A,Falkai P,Malchow B,Schmitt A,Hasan A

    更新日期:2019-09-01 00:00:00

  • The involvement of the striatum in decision making.

    abstract::Decision making has been extensively studied in the context of economics and from a group perspective, but still little is known on individual decision making. Here we discuss the different cognitive processes involved in decision making and its associated neural substrates. The putative conductors in decision making ...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Goulet-Kennedy J,Labbe S,Fecteau S

    更新日期:2016-03-01 00:00:00

  • Epigenetic signaling in psychiatric disorders: stress and depression.

    abstract::Psychiatric disorders are complex multifactorial disorders involving chronic alterations in neural circuit structure and function. While genetic factors play a role in the etiology of disorders such as depression, addiction, and schizophrenia, relatively high rates of discordance among identical twins clearly point to...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Bagot RC,Labonté B,Peña CJ,Nestler EJ

    更新日期:2014-09-01 00:00:00

  • Are there anxious genes?

    abstract::Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Methods for the genetic analysis of such complex disorders is briefly reviewed, followed by a discussion of the comorbidity of anxiety wit...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:

    authors: Morris-Rosendahl DJ

    更新日期:2002-09-01 00:00:00

  • Addressing neuropsychiatric disturbances during rehabilitation after traumatic brain injury: current and future methods.

    abstract::Cognitive, emotional, behavioral, and sensorimotor disturbances are the principal clinical manifestations of traumatic brain injury (TBI) throughout the early postinjury period. These post-traumatic neuropsychiatric disturbances present substantial challenges to patients, their families, and clinicians providing their...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Arciniegas DB

    更新日期:2011-01-01 00:00:00

  • Opposite effects of stressful experience on memory formation in males versus females.

    abstract::It has become increasingly clear that males and females differ even more dramatically than we previously thought. Not only do they exhibit differing responses to stress and environmental experience, but they can also respond in opposite directions. In rats, it has been shown that exposure to an acute stressful event c...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:

    authors: Shors TJ

    更新日期:2002-06-01 00:00:00

  • Childhood predictors of states of anxiety.

    abstract::Development of the characteristics of social phobia often requires a diathesis in the form of a temperamental bias. A behavioral profile marked by vigorous motor activity and crying to unfamiliar stimuli at 4 months of age - called high reactivity- is characteristic of about 20% of healthy, Caucasian infants. This pat...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章

    doi:

    authors: Kagan J

    更新日期:2002-09-01 00:00:00

  • SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence.

    abstract::Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography with a specific focus on a...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Nehlig A,Armspach JP,Namer IJ

    更新日期:2010-01-01 00:00:00

  • Patient-reported outcomes in post-traumatic stress disorder. Part II: focus on pharmacological treatment.

    abstract::Post-traumatic stress disorder (PTSD) may be associated with long-lasting psychological suffering, distressing psychosocial disability, markedly reduced health-related quality of life, and increased morbidity and mortality in a subgroup of individuals in the aftermath of serious traumatic events. Both etiopathogenesis...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Kapfhammer HP

    更新日期:2014-06-01 00:00:00

  • Epilepsy research: a window onto function to and dysfunction of the human brain.

    abstract::As one of the most common neurological disorders, epilepsy has devastating behavioral, social, and occupational consequences and is associated with accumulating brain damage and neurological deficits. Epilepsy comprises a large number of syndromes, which vary greatly with respect to their etiology and clinical feature...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Beck H,Elger CE

    更新日期:2008-01-01 00:00:00

  • Pharmacologic treatment of schizophrenia.

    abstract::Despite pharmacologic advances, the treatment of schizophrenia remains a challenge, and suboptimal outcomes are still all too frequent. Although treatment goals of response, remission, and recovery have been defined more uniformly, a good "effectiveness" measure mapping onto functional outcomes is still lacking. Moreo...

    journal_title:Dialogues in clinical neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Kane JM,Correll CU

    更新日期:2010-01-01 00:00:00