Abstract：
:Late-life depression (LLD) is a growing public and global health concern with diverse clinical manifestations and etiology. This literature review summarizes neuroimaging findings associated with depression in older adults and treatment-response variability. LLD has been associated with cerebral atrophy, diminished myelin integrity, and cerebral lesions in frontostriatal-limbic regions. These associations help explain the depression-executive dysfunction syndrome observed in LLD, and support cerebrovascular burden as a pathogenic mechanism. Furthermore, this review suggests that neuroimaging determinants of treatment resistance also reflect cerebrovascular burden. Of the theoretical etiologies of LLD, cerebrovascular burden may mediate treatment resistance. This review proposes that neuroimaging has the potential for clinical translation. Controlled trials may identify neuroimaging biomarkers that may inform treatment by identifying depressed adults likely to remit with pharmacotherapy, identifying individualized therapeutic dose, and facilitating earlier treatment response measures. Neuroimaging also has the potential to similarly inform treatment response variability from treatment with aripiprazole (dopamine modulator) and buprenorphine (opiate modulator). :La depresión en la edad avanzada (DEA) es una preocupación creciente de salud general y pública, con diversas manifestaciones clínicas y etiologías. Este artículo revisa de manera resumida los hallazgos de las neuroimágenes asociados con la depresión en adultos mayores y la variabilidad de la respuesta terapéutica. La DEA se ha asociado con atrofia cerebral, disminución de la integridad de la mielina y lesiones cerebrales en las regiones límbicas-frontoestriatales. Estas asociaciones ayudan a explicar el síndrome de disfunción ejecutiva de la depresión observado en la DEA y apoyan la carga cerebrovascular como un mecanismo patogénico. Este artículo sugiere además que los hallazgos esenciales de las neuroimágenes de la resistencia al tratamiento también reflejan la carga cerebrovascular. Entre las teorías etiológicas de la DEA, la carga cerebrovascular puede mediar la resistencia al tratamiento. Esta revisión propone que las neuroimágenes tienen un potencial en la traslación clínica. Los ensayos controlados pueden identificar biomarcadores de neuroimágenes que orienten el tratamiento al identificar adultos con depresión que probablemente remitirán con farmacoterapia, identificar dosis terapéuticas individualizadas y facilitar las mediciones de respuesta terapéutica precoz. Las neuroimágenes también tienen el potencial de orientar de manera similar la variabilidad de la respuesta terapéutica del tratamiento con aripiprazol (modulador dopaminérgico) y con buprenorfina (modulador opiáceo). :La dépression du sujet âgé est un problème croissant de santé publique et mondiale dont l'étiologie et les manifestations cliniques sont variées. Cette revue de la littérature résume les résultats de neuro-imagerie associés à la dépression chez les personnes âgées ainsi que la variabilité de la réponse au traitement. La dépression du sujet âgé s'associe à une atrophie cérébrale, à une perte d'intégrité de la myéline et à des lésions cérébrales dans les régions fronto-striato-limbiques. Ces associations permettent d'expliquer le syndrome de dysfonction exécutive observé dans la dépression du sujet âgé et sont en faveur d'une charge cérébrovasculaire comme mécanisme pathogène. De plus, d'après cet article, les facteurs de la résistance au traitement en neuro-imagerie reflètent aussi cette charge. Selon les étiologies théoriques de la dépression du sujet âgé, cette charge cérébrovasculaire jouerait un rôle de médiateur dans la résistance au traitement. Cet article propose que la neuro-imagerie en soit la traduction clinique. Des études contrôlées peuvent déterminer des biomarqueurs de neuro-imagerie qui renseigneraient le traitement en identifiant les adultes déprimés susceptibles de guérir avec un traitement médicamenteux, en précisant la dose thérapeutique personnalisée et en facilitant les mesures précoces de réponse au traitement. La neuro-imagerie peut également informer de la même façon sur la variabilité de la réponse au traitement avec l'aripiprazole (modulateur de la dopamine) et avec la buprénorphine (modulateur opiacé).
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Agudelo C,Aizenstein HJ,Karp JF,Reynolds CF 3rdsubject
Has Abstractpub_date
2015-06-01 00:00:00pages
151-69issue
2eissn
1294-8322issn
1958-5969journal_volume
17pub_type
杂志文章,评审abstract：:Schizophrenia is still a condition with obscure causes and psychopathology. This paper aims to discuss the "disconnectivity" hypothesis in relation to some neurological conditions which are known to alter brain connectivity, as well as mimicking some aspects of the disorder. After a short historical introduction to th...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-06-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
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更新日期：2016-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：:The relationship between stress and infertility has been debated for years. Women with infertility report elevated levels of anxiety and depression, so it is clear that infertility causes stress. What is less clear, however, is whether or not stress causes infertility. The impact of distress on treatment outcome is di...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：10.31887/DCNS.2020.22.2/mkorte
更新日期：2020-06-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2012-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 社论
doi：10.31887/DCNS.2020.22.1/fthibaut
更新日期：2020-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota-the collection of commensal organisms that live in and on each of us-contributes ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2019-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
