Abstract:
:Schizophrenia is still a condition with obscure causes and psychopathology. This paper aims to discuss the "disconnectivity" hypothesis in relation to some neurological conditions which are known to alter brain connectivity, as well as mimicking some aspects of the disorder. After a short historical introduction to the concept, we will examine the evidence for connectivity problems in schizophrenia, separating the anatomical level from the functional level. Then, we will discuss three different issues concerning connectivity: i) local reduction in connectivity without neuronal loss (within the gray matter); ii) reduction in or alteration of long-range connectivity (within the white matter); and iii) abnormal targets for connections. For each of these aspects, we will look at the conditions able to reproduce anomalies capable of increasing susceptibility to schizophrenia. We conclude that psychosis is more likely to occur: i) when long-range connectivity is concerned; ii) when lesions result in lengthening and scattering of conduction times; and iii) when there are high dopamine levels, shedding light on or adding weight to the idea of an interaction between dopamine and connectivity.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Foucher JR,Luck Dsubject
Has Abstractpub_date
2006-01-01 00:00:00pages
17-27issue
1eissn
1294-8322issn
1958-5969journal_volume
8pub_type
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
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journal_title:Dialogues in clinical neuroscience
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doi:10.31887/DCNS.2019.21.3/aschmitt
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
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journal_title:Dialogues in clinical neuroscience
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doi:
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
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