Do we need to rethink our current classifications of mental disorders?
.

abstract：:This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism. We inspect clinical genetic evidence for the familialityl heritability of GAD and cross-disorder phenot...

journal_title：Dialogues in clinical neuroscience

authors： Gottschalk MG,Domschke K

更新日期：2017-06-01 00:00:00

abstract：:This overview will outline the current results of neuroscience research on the possible effects of digital media use on the human brain, cognition, and behavior. This is of importance due to the significant amount of time that individuals spend using digital media. Despite several positive aspects of digital media, wh...

journal_title：Dialogues in clinical neuroscience

authors： Korte M

更新日期：2020-06-01 00:00:00

abstract：:The frontoparietal network is critical for our ability to coordinate behavior in a rapid, accurate, and flexible goal-driven manner. In this review, we outline support for the framing of the frontoparietal network as a distinct control network, in part functioning to flexibly interact with and alter other functional b...

journal_title：Dialogues in clinical neuroscience

authors： Marek S,Dosenbach NUF

更新日期：2018-06-01 00:00:00

abstract：:The current clinical use of psychotropic drugs is transnosologically oriented. This is facilitated by the current classification of mental disorders (International Classification of Diseases, 10th Revision [ICD-10]) and is perhaps justified if depression and psychosis (taken here as examples) are considered as being c...

journal_title：Dialogues in clinical neuroscience

authors： Ackenheil M,Montane Jaime LK

更新日期：1999-12-01 00:00:00

abstract：:Obsessive-compulsive disorder (OCD) is a serious psychiatric disorder that affects approximately 2% of the populations of children and adults. Family aggregation studies have demonstrated that OCD is familial, and results from twin studies demonstrate that the familiality is due in part to genetic factors. Only three ...

journal_title：Dialogues in clinical neuroscience

authors： Pauls DL

更新日期：2010-01-01 00:00:00

abstract：:The construct of major depressive disorder makes no etiological assumptions about populations with diverse symptom clusters. "Depressed mood" and "loss of interest or pleasure in nearly all activities" are core features of major depressive episode, though a strong case can be made to pay increasing attention to sympto...

journal_title：Dialogues in clinical neuroscience

authors： Kennedy SH

更新日期：2008-01-01 00:00:00

abstract：:In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with ...

journal_title：Dialogues in clinical neuroscience

authors： Baron-Cohen S,Lombardo MV

更新日期：2017-12-01 00:00:00

abstract：:Decision making has been extensively studied in the context of economics and from a group perspective, but still little is known on individual decision making. Here we discuss the different cognitive processes involved in decision making and its associated neural substrates. The putative conductors in decision making ...

journal_title：Dialogues in clinical neuroscience

authors： Goulet-Kennedy J,Labbe S,Fecteau S

更新日期：2016-03-01 00:00:00

abstract：:Accumulating evidence suggests that psychotropic agents such as mood stabilizers, antidepressants, and antipsychotics realize their neurotrophic/neuroprotective effects by activating the mitogen activated protein kinase/extracellular signal-related kinase, PI3-kinase, and wingless/glycogen synthase kinase (GSK) 3 sign...

journal_title：Dialogues in clinical neuroscience

authors： Hunsberger J,Austin DR,Henter ID,Chen G

更新日期：2009-01-01 00:00:00

abstract：:Pharmacogenomic developments hold promise for personalized medicine in psychiatry with adjusted therapeutic doses, predictable responses, reduced adverse drug reactions, early diagnosis, and personal health planning. The prospects are exciting, but at the same time, these new techniques stand faced with important scie...

journal_title：Dialogues in clinical neuroscience

authors： Evers K

更新日期：2009-01-01 00:00:00

abstract：:Mental disorders represent a significant public health burden worldwide due to their high prevalence, chronically disabling nature, and substantial impact on quality of life. Despite growing knowledge of the pathological mechanisms that underlie the development of these disorders, a high percentage of patients do not ...

journal_title：Dialogues in clinical neuroscience

authors： Scherma M,Muntoni AL,Riedel G,Fratta W,Fadda P

更新日期：2020-09-01 00:00:00

abstract：:Nosological classification in psychiatry, as it is currently applied, does not facilitate biological and psychopharmacological research.• Syndromal acuity has disappeared. Consequently, it is impossible to determine: (i) vi/hether a particular drug affects a particular symptom configuration; (ii) what exactly the beha...

journal_title：Dialogues in clinical neuroscience

authors： van Praag HM

更新日期：1999-12-01 00:00:00

abstract：:Wider use of pharmacological models would facilitate the development of new drugs for Alzheimer's disease (AD), The two main models currently used are based on the cholinergic and glutamatergic hypotheses of AD, Although they lead to some of the attention and memory impairment observed in AD, they do not fully reprodu...

journal_title：Dialogues in clinical neuroscience

authors： Gilles C,Ertlé S

更新日期：2000-09-01 00:00:00

abstract：:Recent research has overcome the old paradigms of the brain as an immunologically privileged organ, and of the exclusive role of neurotransmitters and neuropeptides as signal transducers in the central nervous system. Growing evidence suggests that the signal proteins of the immune system - the cytokines - are also in...

journal_title：Dialogues in clinical neuroscience

authors： Schwarz MJ

更新日期：2003-06-01 00:00:00

abstract：:We carried out two studies to test the hypothesis that altered central serotonergic function, as assessed by lower prolactin (PRL) response to fenfluramine (D-FEN), is more closely associated with suicidal behavior than a particular psychiatric diagnosis. A D-FEN test was performed in 85 major depressed inpatients, 33...

journal_title：Dialogues in clinical neuroscience

authors： Corrêa H,Romano-Silva MA,Duval F,Campi-Azevedo AC,Lima V,Macher JP

更新日期：2002-12-01 00:00:00

abstract：:A wide range of Internet interventions, mostly grounded in methods of cognitive behavioral therapy, have been developed and tested for several mental disorders. The evidence to date shows that these interventions are effective in reducing symptoms of depression. Metaanalyses report small-to-medium effect sizes when In...

journal_title：Dialogues in clinical neuroscience

authors： Schröder J,Berger T,Westermann S,Klein JP,Moritz S

更新日期：2016-06-01 00:00:00

abstract：:As one of the most common neurological disorders, epilepsy has devastating behavioral, social, and occupational consequences and is associated with accumulating brain damage and neurological deficits. Epilepsy comprises a large number of syndromes, which vary greatly with respect to their etiology and clinical feature...

journal_title：Dialogues in clinical neuroscience

authors： Beck H,Elger CE

更新日期：2008-01-01 00:00:00

abstract：:There is mounting evidence that recurrent mood disorders - once considered "good prognosis diseases"- are, in fact, often very severe and life-threatening illnesses. Furthermore, although mood disorders have traditionally been conceptualized as neurochemical disorders, there is now evidence from a variety of sources d...

journal_title：Dialogues in clinical neuroscience

authors： Quiroz JA,Manji HK

更新日期：2002-03-01 00:00:00

abstract：:Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart f...

journal_title：Dialogues in clinical neuroscience

authors： Holzschneider K,Mulert C

更新日期：2011-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) may be associated with long-lasting psychological suffering, distressing psychosocial disability, markedly reduced health-related quality of life, and increased morbidity and mortality in a subgroup of individuals in the aftermath of serious traumatic events. Both etiopathogenesis...

journal_title：Dialogues in clinical neuroscience

authors： Kapfhammer HP

更新日期：2014-06-01 00:00:00

abstract：:It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We re...

journal_title：Dialogues in clinical neuroscience

authors： Zimmerman M,Morgan TA

更新日期：2013-06-01 00:00:00

abstract：:Sleep disorders in children and adolescents is a topic that has been, and remains, neglected in both public health education and professional training. Although much knowledge has been accumulated in recent times, it has been poorly disseminated and, therefore, relatively little is put into practice. Only some general...

journal_title：Dialogues in clinical neuroscience

authors： Stores G

更新日期：2009-01-01 00:00:00

abstract：:There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidat...

journal_title：Dialogues in clinical neuroscience

authors： Bondy B

更新日期：2003-06-01 00:00:00

abstract：:Despite the fact that 50 years have passed since the Nazi regime and the Holocaust the psychic sequelae are far from being overcome. The majority of Holocaust survivors and World War II veterans still list their experiences as the "most significant stressors" of their lives. The literature provides ample evidence that...

journal_title：Dialogues in clinical neuroscience

authors： Barak Y,Szor H

更新日期：2000-03-01 00:00:00

abstract：:Schizophrenia and bipolar disorder have a largely unknown pathophysiology and etiology, but they are highly heritable. Although linkage and association studies have identified a series of chromosomal regions likely to contain susceptibility genes, progress in identifying causative genes has been largely disappointing....

journal_title：Dialogues in clinical neuroscience

authors： Nöthen MM,Nieratschker V,Cichon S,Rietschel M

更新日期：2010-01-01 00:00:00

abstract：:Late-life depression (LLD) is a growing public and global health concern with diverse clinical manifestations and etiology. This literature review summarizes neuroimaging findings associated with depression in older adults and treatment-response variability. LLD has been associated with cerebral atrophy, diminished my...

journal_title：Dialogues in clinical neuroscience

authors： Agudelo C,Aizenstein HJ,Karp JF,Reynolds CF 3rd

更新日期：2015-06-01 00:00:00

abstract：:Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota-the collection of commensal organisms that live in and on each of us-contributes ...

journal_title：Dialogues in clinical neuroscience

authors： Surana NK

更新日期：2019-01-01 00:00:00

abstract：:With his early publications (1910-1913), Karl Jaspers created a comprehensive methodological arsenal for psychiatry, thus laying the foundation for descriptive psychopathology. Following Edmund Husserl, the founder of philosophical phenomenology, Jaspers introduced phenomenology into psychopathology as "static underst...

journal_title：Dialogues in clinical neuroscience

authors： Häfner H

更新日期：2015-03-01 00:00:00

abstract：:The links between late-life depression and the medical comorbidities that are often associated with it can be divided into two paths. The path from medical illness to depression reflects general mechanisms related to stress, disability, and loss, as well as more specific physiological mechanisms, including those relat...

journal_title：Dialogues in clinical neuroscience

authors： Katz IR

更新日期：1999-09-01 00:00:00

abstract：:Biomarkers have been receiving increasing attention, especially in the field of psychiatry In contrast to the availability of potent therapeutic tools including pharmacotherapy, psychotherapy, and biological therapies, unmet needs remain in terms of onset of action, stability of response, and further improvement of th...

journal_title：Dialogues in clinical neuroscience

authors： Wiedemann K

更新日期：2011-01-01 00:00:00