Abstract：
:Major depressive disorder (MDD) is a major public health concern. Despite tremendous advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by modulating translation, messenger RNA (mRNA) degradation, or stability of mRNA targets. The role of miRNAs in disease pathophysiology is emerging rapidly. Recent studies demonstrating the involvement of miRNAs in several aspects of neural plasticity, neurogenesis, and stress response, and more direct studies in human postmortem brain provide strong evidence that miRNAs can not only play a critical role in MDD pathogenesis, but can also open up new avenues for the development of therapeutic targets. Circulating miRNAs are now being considered as possible biomarkers in disease pathogenesis and in monitoring therapeutic responses because of the presence and/or release of miRNAs in blood cells as well as in other peripheral tissues. In this review, these aspects are discussed in a comprehensive and critical manner. :El trastorno depresivo mayor (TDM) es un importante tema de salud pública. A pesar de los enormes avances, aun no están aclarados los mecanismos patogénicos asociados con el TDM. Además, un número significativo de sujetos con TDM no responden a los medicamentos actualmente disponibles. Los microARNs (miARNs) constituyen una clase de ARNs pequeños no codificantes que controlan la expresión génica al modular la translación, la degradación del ARN mensajero (ARNm) o la estabilidad de los blancos del ARNm. Rápidamente está apareciendo un nuevo papel para los miARNs en la fisiopatología de la enfermedad. Hay estudios recíentes que demuestran la participación de los miARNs en diversos aspectos de la plasticidad neural, la neurogénesis y la respuesta al estrés. Estudios más específicos en cerebro humano postmortem aportan importante evidencia relacionada con el papel crítico que pueden jugar los miARNs en la patogénesis del TDM, y también en la apertura de nuevos caminos para el desarrollo de blancos terapéuticos. Los miARNs circulantes se están considerando actualmente como posibles biomarcadores en la patogénesis de la enfermedad y en el monitoreo de las respuestas terapéuticas dada la presencia ylo liberación de los miARNs en las células sanguíneas como en otros tejidos periféricos. En esta revisión se discuten estos aspectos de una forma crítica y comprensible. :L'épisode dépressif caracterisé (EDC) est un problème majeur de santé publique. Malgré des progrès considérables, les mécanismes pathogènes associés à l'EDC restent obscurs. De plus, un nombre significatif de personnes atteintes d'EDC ne répond pas aux traitements actuellement disponibles. Les microARN (miARN) sont une classe de petits ARN non codants qui contrôlent l'expression du gène en modulant la translation, la dégradation de l'ARN messager (ARNm) ou la stabilité des cibles de l'ARNm. La connaissance du rôle des miARN dans la physiopathologie des maladies prend rapidement de l'essor. Des études récentes démontrant l'implication des miARN dans plusieurs aspects de plasticité neuronale, de neurogenèse, de réponse au stress et d'études plus directes dans le cerveau humain postmortem affirment que les miARN non seulement jouent un rôle décisif dans la pathogenèse de l'EDC, mais qu'ils peuvent aussi inaugurer de nouvelles voies pour le développement de cibles thérapeutiques. Les miARN circulants sont maintenant considérés comme des biomarqueurs possibles dans la pathogenèse de la maladie et dans les réponses thérapeutiques de contrôle à cause de la présence et/ou de la libération des miARN dans les cellules sanguines comme dans d'autres tissus périphériques. Nous analysons dans cet article ces différents aspects de façon complète et critique.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Dwivedi Ysubject
Has Abstractpub_date
2014-03-01 00:00:00pages
43-61issue
1eissn
1294-8322issn
1958-5969journal_volume
16pub_type
杂志文章,评审abstract：:Psychiatric disorders are complex multifactorial disorders involving chronic alterations in neural circuit structure and function. While genetic factors play a role in the etiology of disorders such as depression, addiction, and schizophrenia, relatively high rates of discordance among identical twins clearly point to...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
abstract：:Inborn errors of metabolism (IEMs) are particularly frequent as diseases of the nervous system. In the pediatric neurologic presentations of IEMs neurodevelopment is constantly disturbed and in fact, as far as biochemistry is involved, any kind of monogenic disease can become an IEM. Clinical features are very diverse...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2018-12-01 00:00:00
abstract：:In this review, we outline critical molecular processes that have been implicated by discovery of genetic mutations in autism. These mechanisms need to be mapped onto the neurodevelopment step(s) gone awry that may be associated with cause in autism. Molecular mechanisms include: (i) regulation of gene expression; (ii...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2012-09-01 00:00:00
abstract：:Human memory is not a literal reproduction of the past, but instead relies on constructive processes that are sometimes prone to error and distortion. Understanding of constructive memory has accelerated during recent years as a result of research that has linked together its cognitive and neural bases. This article f...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2012-03-01 00:00:00
abstract：:Technology in genetics and brain imaging has advanced so rapidly that it is difficult to be knowledgeable about all the new tools being used in the pursuit of progress toward understanding and treating mental illness. While findings from new studies remain promising, caution is needed with regard to their current appl...
journal_title：Dialogues in clinical neuroscience
pub_type： 社论
doi：
更新日期：2014-12-01 00:00:00
abstract：:Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart f...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:The recognition that there are fundamental biological sex differences that extend beyond those that define sexual behavior and reproductive function has inspired the drive toward inclusion of both sexes in research design. This is supported by an underlying clinical rationale that studying both sexes is necessary to e...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
abstract：:A wide range of Internet interventions, mostly grounded in methods of cognitive behavioral therapy, have been developed and tested for several mental disorders. The evidence to date shows that these interventions are effective in reducing symptoms of depression. Metaanalyses report small-to-medium effect sizes when In...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-06-01 00:00:00
abstract：:Nosological classification in psychiatry, as it is currently applied, does not facilitate biological and psychopharmacological research.• Syndromal acuity has disappeared. Consequently, it is impossible to determine: (i) vi/hether a particular drug affects a particular symptom configuration; (ii) what exactly the beha...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Methods for the genetic analysis of such complex disorders is briefly reviewed, followed by a discussion of the comorbidity of anxiety wit...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Recent research has overcome the old paradigms of the brain as an immunologically privileged organ, and of the exclusive role of neurotransmitters and neuropeptides as signal transducers in the central nervous system. Growing evidence suggests that the signal proteins of the immune system - the cytokines - are also in...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders. Sleep distu...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Emotional processes are central to behavior, yet their deeply subjective nature has been a challenge for neuroscientific study as well as for psychiatric diagnosis. Here we explore the relationships between subjective feelings and their underlying brain circuits from a computational perspective. We apply recent insigh...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：:Despite the fact that 50 years have passed since the Nazi regime and the Holocaust the psychic sequelae are far from being overcome. The majority of Holocaust survivors and World War II veterans still list their experiences as the "most significant stressors" of their lives. The literature provides ample evidence that...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Patients with cancer and depression experience more physical symptoms, have poorer quality of life, and are more likely to have suicidal thoughts or a desire for hastened death than are cancer patients who are not depressed. Despite the ubiquity of depressive symptoms in cancer patients at the end of life, critical qu...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2017-12-01 00:00:00
abstract：:The first generation of antipsychotic drugs was discovered in the 1960s and 1970s, These agents were effective in treating psychosis, but were accompanied by significant side effects, including severe parkinsonism and akathisia. Second-generation antipsychotics were introduced in the 1990s, These drugs have at least e...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Cognitive, emotional, behavioral, and sensorimotor disturbances are the principal clinical manifestations of traumatic brain injury (TBI) throughout the early postinjury period. These post-traumatic neuropsychiatric disturbances present substantial challenges to patients, their families, and clinicians providing their...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Understanding individual response to a drug-what determines its efficacy and tolerability-is the major bottleneck in current drug development and clinical trials. Intracellular response and metabolism, for example through cytochrome P-450 enzymes, may either enhance or decrease the effect of different drugs, dependent...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:Depressive disorders are a leading cause of disability worldwide and greatly impact morbidity, health care utilization, and medical costs. Major depression that does not resolve with adequate antidepressant treatment is termed treatment-resistant depression (TRD), There is no universally accepted definition of TRD and...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:Similar to other complex disorders, the etiology of Alzheimer disease is multifactorial and characterized by an interplay of biological and environmental risk and protective factors. Potentially modifiable risk factors have emerged from epidemiological research and strategies to prevent neurodegeneration and dementia ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Sleep disorders in children and adolescents is a topic that has been, and remains, neglected in both public health education and professional training. Although much knowledge has been accumulated in recent times, it has been poorly disseminated and, therefore, relatively little is put into practice. Only some general...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:Despite pharmacologic advances, the treatment of schizophrenia remains a challenge, and suboptimal outcomes are still all too frequent. Although treatment goals of response, remission, and recovery have been defined more uniformly, a good "effectiveness" measure mapping onto functional outcomes is still lacking. Moreo...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Schizophrenia and bipolar disorder have a largely unknown pathophysiology and etiology, but they are highly heritable. Although linkage and association studies have identified a series of chromosomal regions likely to contain susceptibility genes, progress in identifying causative genes has been largely disappointing....
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:The introduction of biological markers in the clinical management of Alzheimer's disease (AD) will not only improve diagnosis relating to early detection of neuropathology with underlying molecular mechanisms, but also provides tools for the assessment of objective treatment benefits. In this review, we identify a num...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:Depression can occur in association with virtually all the other psychiatric and physical diagnoses. Physical illness increases the risk of developing severe depressive illness. There are two broadly different mechanisms. The most obvious has a psychological or cognitive mechanism. Thus, the illness may provide the li...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography with a specific focus on a...
journal_title：Dialogues in clinical neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2010-01-01 00:00:00
abstract：:Impairment of cognitive function is the central feature of dementia. Although, clinically, the cognitive deficit most often manifests itself as memory problems, a number of other areas of cognition are affected, and memory is but one of the cognitive skills compromised in dementia. Dementia with Lewy bodies, for examp...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota-the collection of commensal organisms that live in and on each of us-contributes ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2019-01-01 00:00:00
abstract：:This overview will outline the current results of neuroscience research on the possible effects of digital media use on the human brain, cognition, and behavior. This is of importance due to the significant amount of time that individuals spend using digital media. Despite several positive aspects of digital media, wh...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：10.31887/DCNS.2020.22.2/mkorte
更新日期：2020-06-01 00:00:00
