New findings in the genetics of major psychoses.

Abstract:

:Schizophrenia and bipolar disorder have a largely unknown pathophysiology and etiology, but they are highly heritable. Although linkage and association studies have identified a series of chromosomal regions likely to contain susceptibility genes, progress in identifying causative genes has been largely disappointing. However, rapid technological advances are beginning to lead to new insights. Systematic genome-wide association and follow-up studies have reported genome-wide significant association findings of common variants for schizophrenia and bipolar disorder. The risk conferred by individual variants is small, and some variants confer a risk for both disorders. In addition, recent studies have identified rare, large structural variants (copy number variants) that confer a greater risk for schizophrenia. This review summarizes recent developments in genetic research into schizophrenia and bipolar disorder, and discusses possible future directions in this field.

authors

Nöthen MM,Nieratschker V,Cichon S,Rietschel M

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

85-93

issue

1

eissn

1294-8322

issn

1958-5969

journal_volume

12

pub_type

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