Abstract:
:Despite the fact that 50 years have passed since the Nazi regime and the Holocaust the psychic sequelae are far from being overcome. The majority of Holocaust survivors and World War II veterans still list their experiences as the "most significant stressors" of their lives. The literature provides ample evidence that posttraumatic stress disorder among survivors persists into old age. However, there is still a need to define the differences in frequency, clinical presentation, severity, and comorbid conditions among aging Holocaust survivors. Age at the time of trauma, cumulative lifetime stress, and physical illness are reported to have a positive association with more severe posttraumatic symptomatology. The presence of comorbid Axis i psychiatric disorders (Diagnostic and Statistical Manual [DSIVI]), has been the focus of research by our group, demonstrating that their interaction with earlier trauma leads to a course of chronic, debilitating disease. Despite reactivation of traumatic symptoms during aging and continuous mental suffering, the majority of Holocaust survivors show good instrumental coping and preserved functioning.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Barak Y,Szor Hsubject
Has Abstractpub_date
2000-03-01 00:00:00pages
57-62issue
1eissn
1294-8322issn
1958-5969journal_volume
2pub_type
杂志文章abstract::The links between late-life depression and the medical comorbidities that are often associated with it can be divided into two paths. The path from medical illness to depression reflects general mechanisms related to stress, disability, and loss, as well as more specific physiological mechanisms, including those relat...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::Partial remission from depression, with residual symptoms, is an important problem in depression. This paper reviews the frequency and features of this outcome, and its association with relapse. Residual symptoms occur in many depressed patients after acute treatment. They span the typical symptoms of depression, exce...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::Depressive disorders are a leading cause of disability worldwide and greatly impact morbidity, health care utilization, and medical costs. Major depression that does not resolve with adequate antidepressant treatment is termed treatment-resistant depression (TRD), There is no universally accepted definition of TRD and...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::Losing a loved to suicide is one is one of life's most painful experiences. The feelings of loss, sadness, and loneliness experienced after any death of a loved one are often magnified in suicide survivors by feelings of quilt, confusion, rejection, shame, anger, and the effects of stigma and trauma. Furthermore, surv...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2012-06-01 00:00:00
abstract::An evidence-based review of nonpharmacological treatments for anxiety disorders is presented. The vast majority of the controlled research is devoted to cognitive behavior therapy (CBT) and shows its efficiency and effectiveness in all the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) ...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::Biomarkers have been receiving increasing attention, especially in the field of psychiatry In contrast to the availability of potent therapeutic tools including pharmacotherapy, psychotherapy, and biological therapies, unmet needs remain in terms of onset of action, stability of response, and further improvement of th...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract::Psychiatric disorders are complex multifactorial disorders involving chronic alterations in neural circuit structure and function. While genetic factors play a role in the etiology of disorders such as depression, addiction, and schizophrenia, relatively high rates of discordance among identical twins clearly point to...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2014-09-01 00:00:00
abstract::We carried out two studies to test the hypothesis that altered central serotonergic function, as assessed by lower prolactin (PRL) response to fenfluramine (D-FEN), is more closely associated with suicidal behavior than a particular psychiatric diagnosis. A D-FEN test was performed in 85 major depressed inpatients, 33...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::Treatment of Parkinson's disease (PD) is complex and often involves addressing behavioral changes in addition to the movement disorder. Patients with PD are susceptible to any psychiatric condition seen in the general population; some disorders, such as depression and anxiety, may result from PD-related neuropathologi...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::Emotional processes are central to behavior, yet their deeply subjective nature has been a challenge for neuroscientific study as well as for psychiatric diagnosis. Here we explore the relationships between subjective feelings and their underlying brain circuits from a computational perspective. We apply recent insigh...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2015-12-01 00:00:00
abstract::In this review, we outline critical molecular processes that have been implicated by discovery of genetic mutations in autism. These mechanisms need to be mapped onto the neurodevelopment step(s) gone awry that may be associated with cause in autism. Molecular mechanisms include: (i) regulation of gene expression; (ii...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2012-09-01 00:00:00
abstract::We now appreciate that estrogen is a pleiotropic gonadal steroid that exerts profound effects on the plasticity and cell survival of the adult brain. Over the past century, the life span of women has increased, but the age of the menopause remains constant. This means that women may now live over one third of their li...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::The traditional categorical classification system and new diagnostic systems will be discussed in this issue. . :Mettre la traduction ES. :Mettre la traduction FR. ...
journal_title:Dialogues in clinical neuroscience
pub_type: 社论
doi:10.31887/DCNS.2020.22.1/fthibaut
更新日期:2020-03-01 00:00:00
abstract::Brain plasticity is an intrinsic characteristic of the nervous system that allows continuous remodeling of brain functions in pathophysiological conditions. Although normal aging is associated with morphological modifications and decline of cerebral functions, brain plasticity is at least partially preserved in elderl...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2013-03-01 00:00:00
abstract::Alcohol dependence is a frequent, chronic, relapsing, and incurable disease with enormous societal costs. Thus, alcoholism therapy and research into its outcome are of major importance for public health. The present article will: (i) give a brief overview of the epidemiology, pathogenesis, and treatment outcomes of al...
journal_title:Dialogues in clinical neuroscience
pub_type: 临床试验,杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) may be associated with long-lasting psychological suffering, distressing psychosocial disability, markedly reduced health-related quality of life, and increased morbidity and mortality in a subgroup of individuals in the aftermath of serious traumatic events. Both etiopathogenesis...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2014-06-01 00:00:00
abstract::The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders. Sleep distu...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::The current clinical use of psychotropic drugs is transnosologically oriented. This is facilitated by the current classification of mental disorders (International Classification of Diseases, 10th Revision [ICD-10]) and is perhaps justified if depression and psychosis (taken here as examples) are considered as being c...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with ...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2017-12-01 00:00:00
abstract::Contemporary biological psychiatry uses experimental animal models to increase our understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly targets specific pathways and molecular determinants within a single phenotypic domain. However, greater understanding of the mechanisms of action...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2015-09-01 00:00:00
abstract::A wide range of Internet interventions, mostly grounded in methods of cognitive behavioral therapy, have been developed and tested for several mental disorders. The evidence to date shows that these interventions are effective in reducing symptoms of depression. Metaanalyses report small-to-medium effect sizes when In...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2016-06-01 00:00:00
abstract::Similar to other complex disorders, the etiology of Alzheimer disease is multifactorial and characterized by an interplay of biological and environmental risk and protective factors. Potentially modifiable risk factors have emerged from epidemiological research and strategies to prevent neurodegeneration and dementia ...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2019-03-01 00:00:00
abstract::Impairment of cognitive function is the central feature of dementia. Although, clinically, the cognitive deficit most often manifests itself as memory problems, a number of other areas of cognition are affected, and memory is but one of the cognitive skills compromised in dementia. Dementia with Lewy bodies, for examp...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidat...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::The first generation of antipsychotic drugs was discovered in the 1960s and 1970s, These agents were effective in treating psychosis, but were accompanied by significant side effects, including severe parkinsonism and akathisia. Second-generation antipsychotics were introduced in the 1990s, These drugs have at least e...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Methods for the genetic analysis of such complex disorders is briefly reviewed, followed by a discussion of the comorbidity of anxiety wit...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We re...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2013-06-01 00:00:00
abstract::As one of the most common neurological disorders, epilepsy has devastating behavioral, social, and occupational consequences and is associated with accumulating brain damage and neurological deficits. Epilepsy comprises a large number of syndromes, which vary greatly with respect to their etiology and clinical feature...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography with a specific focus on a...
journal_title:Dialogues in clinical neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2010-01-01 00:00:00
abstract::The present study was conducted in order to investigate the relationships between central noradrenergic (NA) and serotonergic (5-HT) function and clinical characteristics of a major depressive episode according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. We measured growth hormone res...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00