Core symptoms of major depressive disorder: relevance to diagnosis and treatment.

abstract：:Brain plasticity is an intrinsic characteristic of the nervous system that allows continuous remodeling of brain functions in pathophysiological conditions. Although normal aging is associated with morphological modifications and decline of cerebral functions, brain plasticity is at least partially preserved in elderl...

journal_title：Dialogues in clinical neuroscience

authors： Chollet F

更新日期：2013-03-01 00:00:00

abstract：:Despite pharmacologic advances, the treatment of schizophrenia remains a challenge, and suboptimal outcomes are still all too frequent. Although treatment goals of response, remission, and recovery have been defined more uniformly, a good "effectiveness" measure mapping onto functional outcomes is still lacking. Moreo...

journal_title：Dialogues in clinical neuroscience

authors： Kane JM,Correll CU

更新日期：2010-01-01 00:00:00

abstract：:In this review, we outline critical molecular processes that have been implicated by discovery of genetic mutations in autism. These mechanisms need to be mapped onto the neurodevelopment step(s) gone awry that may be associated with cause in autism. Molecular mechanisms include: (i) regulation of gene expression; (ii...

journal_title：Dialogues in clinical neuroscience

authors： Pescosolido MF,Yang U,Sabbagh M,Morrow EM

更新日期：2012-09-01 00:00:00

abstract：:Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota-the collection of commensal organisms that live in and on each of us-contributes ...

journal_title：Dialogues in clinical neuroscience

authors： Surana NK

更新日期：2019-01-01 00:00:00

abstract：:Emotional processes are central to behavior, yet their deeply subjective nature has been a challenge for neuroscientific study as well as for psychiatric diagnosis. Here we explore the relationships between subjective feelings and their underlying brain circuits from a computational perspective. We apply recent insigh...

journal_title：Dialogues in clinical neuroscience

authors： Kepecs A,Mensh BD

更新日期：2015-12-01 00:00:00

abstract：:Major depressive disorder (MDD) is a major public health concern. Despite tremendous advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small noncoding RNAs tha...

journal_title：Dialogues in clinical neuroscience

authors： Dwivedi Y

更新日期：2014-03-01 00:00:00

abstract：:Mental disorders represent a significant public health burden worldwide due to their high prevalence, chronically disabling nature, and substantial impact on quality of life. Despite growing knowledge of the pathological mechanisms that underlie the development of these disorders, a high percentage of patients do not ...

journal_title：Dialogues in clinical neuroscience

authors： Scherma M,Muntoni AL,Riedel G,Fratta W,Fadda P

更新日期：2020-09-01 00:00:00

abstract：:The validity of diagnostic definitions in psychiatry is directly related to the extent to which their etiology can be specified. However, since detailed knowledge of causal or susceptibility factors is lacking for most psychiatric disorders with a known or suspected familial-genetic origin, the current widely accepted...

journal_title：Dialogues in clinical neuroscience

authors： Maier W

更新日期：1999-12-01 00:00:00

abstract：:Nosological classification in psychiatry, as it is currently applied, does not facilitate biological and psychopharmacological research.• Syndromal acuity has disappeared. Consequently, it is impossible to determine: (i) vi/hether a particular drug affects a particular symptom configuration; (ii) what exactly the beha...

journal_title：Dialogues in clinical neuroscience

authors： van Praag HM

更新日期：1999-12-01 00:00:00

abstract：:Every human is unique. We differ in our genomes, environment, behavior, disease history, and past and current medical treatment-a complex catalog of differences that often leads to variations in the way each of us responds to a particular therapy. We argue here that true personalization of drug therapies will rely on ...

journal_title：Dialogues in clinical neuroscience

authors： Lehrach H

更新日期：2016-09-01 00:00:00

abstract：:The insights of ethology-the science of animal behavior from a biological and psychological point of view-were incorporated in the 1950s by the British developmental psychiatrist, John Bowlby, into his attachment theory, which argued that a secure affective base in infancy was critical to the normal development of per...

journal_title：Dialogues in clinical neuroscience

authors： Cyrulnik B

更新日期：2005-01-01 00:00:00

abstract：:Despite the fact that 50 years have passed since the Nazi regime and the Holocaust the psychic sequelae are far from being overcome. The majority of Holocaust survivors and World War II veterans still list their experiences as the "most significant stressors" of their lives. The literature provides ample evidence that...

journal_title：Dialogues in clinical neuroscience

authors： Barak Y,Szor H

更新日期：2000-03-01 00:00:00

abstract：:The traditional categorical classification system and new diagnostic systems will be discussed in this issue.
. :Mettre la traduction ES. :Mettre la traduction FR. ...

journal_title：Dialogues in clinical neuroscience

authors： Thibaut F

更新日期：2020-03-01 00:00:00

abstract：:Partial remission from depression, with residual symptoms, is an important problem in depression. This paper reviews the frequency and features of this outcome, and its association with relapse. Residual symptoms occur in many depressed patients after acute treatment. They span the typical symptoms of depression, exce...

journal_title：Dialogues in clinical neuroscience

authors： Paykel ES

更新日期：2008-01-01 00:00:00

abstract：:Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Methods for the genetic analysis of such complex disorders is briefly reviewed, followed by a discussion of the comorbidity of anxiety wit...

journal_title：Dialogues in clinical neuroscience

authors： Morris-Rosendahl DJ

更新日期：2002-09-01 00:00:00

abstract：:Treatment of Parkinson's disease (PD) is complex and often involves addressing behavioral changes in addition to the movement disorder. Patients with PD are susceptible to any psychiatric condition seen in the general population; some disorders, such as depression and anxiety, may result from PD-related neuropathologi...

journal_title：Dialogues in clinical neuroscience

authors： Anderson KE

更新日期：2004-09-01 00:00:00

abstract：:Epidemiological studies show that anxiety disorders are highly prevalent and an important cause of functional impairment; they constitute the most frequent menial disorders in the community. Phobias are the most common with the highest rates for simple phobia and agoraphobia. Panic disorder (PD) and obsessive-compulsi...

journal_title：Dialogues in clinical neuroscience

authors： Martin P

更新日期：2003-09-01 00:00:00

abstract：:Alcohol dependence (alcoholism) is a complex disorder attributed to the interaction of genetic and environmental factors that form a collage of "disease" predisposition, which is not identical for every alcohol-dependent individual. There is considerable evidence to demonstrate that genetic predisposition accounts for...

journal_title：Dialogues in clinical neuroscience

authors： Hines LM,Ray L,Hutchison K,Tabakoff B

更新日期：2005-01-01 00:00:00

abstract：:Cognitive, emotional, behavioral, and sensorimotor disturbances are the principal clinical manifestations of traumatic brain injury (TBI) throughout the early postinjury period. These post-traumatic neuropsychiatric disturbances present substantial challenges to patients, their families, and clinicians providing their...

journal_title：Dialogues in clinical neuroscience

authors： Arciniegas DB

更新日期：2011-01-01 00:00:00

abstract：:Several structural deviances in the brain in "endogenous psychoses" have been described over the last decades. The enlargement of the lateral ventricles and the subtle structural deficits in temporobasal and orbital frontal structures (hypofrontality) are reasonably well established in the majority of schizophrenic pa...

journal_title：Dialogues in clinical neuroscience

authors： Beckmann H,Jakob H,Senitz D

更新日期：2006-01-01 00:00:00

abstract：:While the legitimacy of medical treatments is more and more questioned, one sees a paradoxical increase in nonconventional approaches, notably so in psychiatry. Over time, approaches that were considered valuable by the scientific community were found to be inefficacious, while other approaches, labelled as alternativ...

journal_title：Dialogues in clinical neuroscience

authors： Schulz P,Hede V

更新日期：2018-09-01 00:00:00

abstract：:Pharmacogenomic developments hold promise for personalized medicine in psychiatry with adjusted therapeutic doses, predictable responses, reduced adverse drug reactions, early diagnosis, and personal health planning. The prospects are exciting, but at the same time, these new techniques stand faced with important scie...

journal_title：Dialogues in clinical neuroscience

authors： Evers K

更新日期：2009-01-01 00:00:00

abstract：:Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart f...

journal_title：Dialogues in clinical neuroscience

authors： Holzschneider K,Mulert C

更新日期：2011-01-01 00:00:00

abstract：:Alcohol dependence is a frequent, chronic, relapsing, and incurable disease with enormous societal costs. Thus, alcoholism therapy and research into its outcome are of major importance for public health. The present article will: (i) give a brief overview of the epidemiology, pathogenesis, and treatment outcomes of al...

journal_title：Dialogues in clinical neuroscience

authors： Krampe H,Stawicki S,Hoehe MR,Ehrenreich H

更新日期：2007-01-01 00:00:00

abstract：:Biomarkers have been receiving increasing attention, especially in the field of psychiatry In contrast to the availability of potent therapeutic tools including pharmacotherapy, psychotherapy, and biological therapies, unmet needs remain in terms of onset of action, stability of response, and further improvement of th...

journal_title：Dialogues in clinical neuroscience

authors： Wiedemann K

更新日期：2011-01-01 00:00:00

abstract：:There is mounting evidence that recurrent mood disorders - once considered "good prognosis diseases"- are, in fact, often very severe and life-threatening illnesses. Furthermore, although mood disorders have traditionally been conceptualized as neurochemical disorders, there is now evidence from a variety of sources d...

journal_title：Dialogues in clinical neuroscience

authors： Quiroz JA,Manji HK

更新日期：2002-03-01 00:00:00

abstract：:Sleep disorders in children and adolescents is a topic that has been, and remains, neglected in both public health education and professional training. Although much knowledge has been accumulated in recent times, it has been poorly disseminated and, therefore, relatively little is put into practice. Only some general...

journal_title：Dialogues in clinical neuroscience

authors： Stores G

更新日期：2009-01-01 00:00:00

abstract：:The first generation of antipsychotic drugs was discovered in the 1960s and 1970s, These agents were effective in treating psychosis, but were accompanied by significant side effects, including severe parkinsonism and akathisia. Second-generation antipsychotics were introduced in the 1990s, These drugs have at least e...

journal_title：Dialogues in clinical neuroscience

authors： Tamminga CA

更新日期：2000-09-01 00:00:00

abstract：:It is timely to consider the ethical and social questions raised by progress in pharmacogenomics, based on the current importance of pharmacogenomics for avoidance of predictable side effects of drugs, and for correct choice of medications in certain cancers. It has been proposed that the entire population be genotype...

journal_title：Dialogues in clinical neuroscience

authors： Gershon ES,Alliey-Rodriguez N,Grennan K

更新日期：2014-12-01 00:00:00

abstract：:Cognitive symptoms are a core feature of schizophrenia and are related to an unfavorable disease outcome. So far, there are no satisfactory pharmacological approaches to address cognitive symptoms. For some time now, aerobic exercise has been demonstrated in various trials to be a promising candidate for this indicati...

journal_title：Dialogues in clinical neuroscience

authors： Maurus I,Röh A,Falkai P,Malchow B,Schmitt A,Hasan A

更新日期：2019-09-01 00:00:00