Abstract：
:The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders. Sleep disturbances in major depressive disorder (MDD) are characterized by increased sleep latency, poorer sleep efficiency reduced latency to the first rapid eye movement (REM) sleep episode, and early-morning awakening, but there is little data to indicate a role of circadian clock genes in MDD. There is also relatively little information regarding the role of clock genes in anxiety. In contrast, a significant amount of evidence gathered in bipolar disorder (BPD) patients suggests a circadian rhythm disorder, namely an advanced circadian rhythm and state-dependent alterations of REM sleep latency. Most research on the role of clock genes in BPD has focused on polymorphisms of CLOCK, but the lithium target GSK3 may also play a significant role. A circadian phase shift is also theorized to contribute to the pathophysiology of winter seasonal affective disorder (SAD). Certain allelic combinations of NPAS2, PER3, and BMAL1 appear to contribute to the risk of SAD. In chronic schizophrenia, disturbances of sleep including insomnia and reduced sleep efficiency have been observed. Genetic studies have found associations with CLOCK, PER1, PER3, and TIMELESS. Sleep and circadian changes associated with dementia due to Alzheimer's disease suggest a functional change in the circadian master clock, which is supported by postmortem studies of clock gene expression in the brain.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Lamont EW,Legault-Coutu D,Cermakian N,Boivin DBsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
333-42issue
3eissn
1294-8322issn
1958-5969journal_volume
9pub_type
杂志文章,评审abstract：:The recognition that there are fundamental biological sex differences that extend beyond those that define sexual behavior and reproductive function has inspired the drive toward inclusion of both sexes in research design. This is supported by an underlying clinical rationale that studying both sexes is necessary to e...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
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更新日期：2013-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
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更新日期：2003-06-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2018-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2013-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 社论
doi：
更新日期：2014-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 传,历史文章,杂志文章
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更新日期：2015-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 社论
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2018-06-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
